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Choline uptake in patients with Alzheimer pre-senile dementia

Published online by Cambridge University Press:  09 July 2009

A. I. M. Glen ,
C. M. Yates ,
J. Simpson ,
J. E. Christie ,
A. Shering ,
L. J. Whalley  and
E. H. Jellinek
A. I. M. Glen
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, Royal Edinburgh Hospital, Edinburgh
C. M. Yates*
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, Royal Edinburgh Hospital, Edinburgh
J. Simpson
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, Royal Edinburgh Hospital, Edinburgh
J. E. Christie
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, Royal Edinburgh Hospital, Edinburgh
A. Shering
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, Royal Edinburgh Hospital, Edinburgh
L. J. Whalley
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, Royal Edinburgh Hospital, Edinburgh
E. H. Jellinek
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, Royal Edinburgh Hospital, Edinburgh
*
1Address for correspondence: Dr C. M. Yates, MRC Brain Metabolism Unit, Department of Pharmacology, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ.
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Synopsis

Serum and CSF choline levels were measured in 12 patients with pre-senile Alzheimer's disease before and 1 hour after administration of 1·5 g choline chloride or 25 g lecithin granules. Serum choline levels were increased threefold and CSF choline levels by 72%. CSF choline levels in the untreated Alzheimer patients did not differ significantly from age-matched controls. In 35 neurological controls, CSF choline levels increased with age (γ = 0·64, P<0·001).

Choline influx into erythrocytes from 10 male and female Alzheimer patients did not differ significantly from 40 male and 43 female controls. Choline influx into erythrocytes was not related to age or sex, although the range was greater (P <0·05) in females than in males.

Our results indicate that there is no impairment of choline transport into CSF or erythrocytes in patients with pre-senile Alzheimer's disease.

Type
Research Article
Information
Psychological Medicine , Volume 11 , Issue 3 , August 1981 , pp. 469 - 476
Copyright
Copyright © Cambridge University Press 1981

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