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Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study

Published online by Cambridge University Press:  09 July 2009

George J. Jurjus ,
Henry A. Nasrallah ,
Stephen C. Olson  and
Steven B. Schwarzkopf
George J. Jurjus
Affiliation:
Department of Psychiatry, The Neuroscience Program, Ohio State University, College of Medicine, Columbus, Ohio, USA
Henry A. Nasrallah*
Affiliation:
Department of Psychiatry, The Neuroscience Program, Ohio State University, College of Medicine, Columbus, Ohio, USA
Stephen C. Olson
Affiliation:
Department of Psychiatry, The Neuroscience Program, Ohio State University, College of Medicine, Columbus, Ohio, USA
Steven B. Schwarzkopf
Affiliation:
Department of Psychiatry, The Neuroscience Program, Ohio State University, College of Medicine, Columbus, Ohio, USA
*
1Address for correspondence: Dr Henry A. Nasrallah, Department of Psychiatry, The Neuroscience Program, Ohio State University, College of Medicine, 473 West 12th Avenue, Columbus, OH 43210, USA.
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Synopsis

Many structural brain abnormalities have been described in schizophrenia, consistent with a neurodevelopmental model for this disease. We report here a study of the cavum septum pellucidum (CSP) in schizophrenia compared to control groups, as well as the clinical correlates of this congenital anomaly in schizophrenia. We conducted a magnetic resonance imaging (MRI) study to compare rates of CSP in schizophrenia (N = 67) v. psychiatric controls (bipolar and schizoaffective, N = 60) and healthy controls (N = 37). Of the controls 18·9 %, and of all psychotic subjects 18·1 % had a CSP of any size and there was no difference in the frequency of large CSP among the groups. Males had higher rates of CSP than females (25% v. 9·7%, P = 0·01) in all groups. Schizophrenics had higher CSP rates than affective patients (25%, v. 10%, P = 0·02). No clinical difference was found between schizophrenics with or without CSP.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 2 , May 1993 , pp. 319 - 322
Copyright
Copyright © Cambridge University Press 1993

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