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Cannabis affects the severity of schizophrenic symptoms: results of a clinical survey

Published online by Cambridge University Press:  09 July 2009

Juan C. Negrete ,
Werner P. Knapp ,
Donald E. Douglas  and
W. Bruce Smith
Juan C. Negrete*
Affiliation:
Alcohol and Drug Dependence Unit, Division of Clinical Chemistry, Toxicology Laboratory, Montreal General Hospital, Montreal, Canada
Werner P. Knapp
Affiliation:
Alcohol and Drug Dependence Unit, Division of Clinical Chemistry, Toxicology Laboratory, Montreal General Hospital, Montreal, Canada
Donald E. Douglas
Affiliation:
Alcohol and Drug Dependence Unit, Division of Clinical Chemistry, Toxicology Laboratory, Montreal General Hospital, Montreal, Canada
W. Bruce Smith
Affiliation:
Alcohol and Drug Dependence Unit, Division of Clinical Chemistry, Toxicology Laboratory, Montreal General Hospital, Montreal, Canada
*
1Address for correspondence: Professor J. C. Negrete, Department of Psychiatry, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Canada H3G 1A4.
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Synopsis

Data on the history of cannabis use and a spot urine test for cannabinoids were obtained for 137 schizophrenics in treatment. Subjects who were using cannabis during the 6-month observation period presented with a significantly higher degree of delusional and hallucinatory activity than those who did not. Moreover, the group using cannabis made a higher average number of visits to the hospital during the same period. The status of cannabis use appeared to contribute to such variance more than did other relevant factors (age, stage of the illness, amount of medication prescribed, occasional use of other psychoactive substances).

Type
Research Article
Information
Psychological Medicine , Volume 16 , Issue 3 , August 1986 , pp. 515 - 520
Copyright
Copyright © Cambridge University Press 1986

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References

Bernhardson, G. & Gunne, L. M. (1972). Forty six cases of psychosis in cannabis abusers. International Journal of Addiction 7, 9–16.Google Scholar
Davison, K. & Wilson, C. H. (1972). Psychosis associated with cannabis smoking. British Journal of Addiction 67, 225–228.Google Scholar
Edwards, G. (1983). Psychopathology of a drug experience. British Journal of Psychiatry 143, 509–512.Google Scholar
Harding, T. & Knight, F. (1973). Marihuana-modified mania. Archives of General Psychiatry 29, 635–637.Google Scholar
Harrow, M., Carone, B. J. & Westermeyer, J. F. (1985). The course of psychosis in early phases of schizophrenia. American Journal of Psychiatry 142, 702–707.Google Scholar
Knudsen, P. & Vilmar, T. (1984). Cannabis and neuroleptic agents in schizophrenia. Acta Psychiatrica Scandinavica 69, 162–174.Google Scholar
Magliozzi, J. R., Kanter, S. L., Csernansky, J. G. & Hollister, L. E. (1983). Detection of marijuana use in psychiatric patients by determination of urinary delta-9-tetrahydro-cannabinol-ll-oic acid. Journal of Nervous and Mental Disease 171, 246–249.Google Scholar
Melges, F. T. (1976). Tracking difficulties and paranoid ideation during hashish and alcohol intoxication. American Journal of Psychiatry 133, 1024–1028.Google ScholarPubMed
Negrete, J. C. (1983). Psychiatric effects of cannabis use. In Cannabis and Health Hazards (ed. Fehr, K. and Kalant, H.), pp. 577–616. Addiction Research Foundation: Toronto.Google Scholar
Negrete, J. C. (1985). Clinical psychiatric complications of cannabis use: an update. In Marihuana '84: Proceedings of the Oxford Symposium on Cannabis (ed. Harvey, D. J. and Paton, W.), pp. 581–592. IRL Press: Oxford.Google Scholar
O'Conner, J. D. & Regent, T. A. (1981). EMIT cannabinoid assay: confirmation by RIA and GC/MS. Journal of Analysis and Toxicology 5, 168–173.Google Scholar
Rottanburg, D., Robins, A. H., Ben-Arie, O., Teggin, A. & Elk, R. (1982). Cannabis-associated psychosis with hypomanic features. Lancet ii, 1364–1366.Google Scholar
Schneider, H. (1976). Drug abuse and schizophrenia. Archiv für Psychiatrie und Nervenkrankheiten 222 (2–3), 267–279.Google Scholar
Tashner, K. L. (1983). Zur Psychopathologie und Differential-diagnose sogennanter cannabis Psychosen (Psychopathology and differential diagnosis of the so-called cannabis psychosis). Fortschritte der Neurologie und Psychiatrie 51 (7), 235–248.Google Scholar
Treffert, D. A. (1978). Marijuana use in schizophrenia: a clear hazard. American Journal of Psychiatry 135, 1213–1215.Google ScholarPubMed
Westermeyer, J. & Walzer, U. (1975). Sociopathy and drug use in a young psychiatric population. Diseases of the Nervous System 36, 673–677.Google Scholar