Hostname: page-component-745bb68f8f-g4j75 Total loading time: 0 Render date: 2025-01-11T21:57:54.310Z Has data issue: false hasContentIssue false
  • English
  • Français

Can linkage and marker association resolve the genetic aetiology of psychiatric disorders? Review and argument1

Published online by Cambridge University Press:  09 July 2009

Elizabeth Sturt  and
Peter McGuffin
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Editorials
Information
Psychological Medicine , Volume 15 , Issue 3 , August 1985 , pp. 455 - 462
Copyright
Copyright © Cambridge University Press 1985

References

REFERENCES

Bishop, Y. M. M., Fienberg, S. E. & Holland, P. W. (1975). Discrete Multivariate Analysis: Theory and Practice. MIT Press: Cambridge, Mass.Google Scholar
Botstein, D., White, R. L., Skolnick, M. & Davis, R. W. (1980). Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics 32, 314–331.Google ScholarPubMed
British Medical Journal (1976). Editorial: Unity and diversity in schizophrenia; iv, 673–674.Google Scholar
Clerget-Darpoux, F. (1982). Bias of the estimated recombination fraction and lod score due to an association between a disease gene and a marker gene. Annals of Human Genetics 46, 363–372.CrossRefGoogle Scholar
Clerget-Darpoux, F. & Bonaiti-Pellie, C. (1980). Epistasis effect: an alternative hypothesis to linkage disequilibrium in HLA associated diseases. Annals of Human Genetics 44, 195–204.CrossRefGoogle ScholarPubMed
Cloninger, C. R., Reich, T. & Yokoyama, S. (1983). Genetic diversity, genome organisation, and investigation of the etiology of psychiatric diseases. Psychiatric Developments 3, 225–246.Google Scholar
Cohen, J. E. (1976). The distribution of the chi-squared statistic under clustered sampling from contingency tables. Journal of the American Statistical Association 71, 665–670.CrossRefGoogle Scholar
Edwards, J. H. (1969). Familial predisposition in man. British Medical Bulletin 25, 58–64.CrossRefGoogle ScholarPubMed
Edwards, J. H. (1980). Allelic association in man. In Aland Isands Symposium (ed. Eriksson, A.), pp. 239–255. Academic Press: New York.Google Scholar
Elston, R. C. & Campbell, M. A. (1970). Schizophrenia: evidence for the major gene hypothesis. Behaviour Genetics 1, 101–106.CrossRefGoogle ScholarPubMed
Elston, R. C. & Stewart, J. (1971). A general model for the genetic analysis of pedigree data. Human Heredity 21, 523–542.CrossRefGoogle ScholarPubMed
Farmer, A. E., McGuffin, P. & Gottesman, I. I. (1984). Searching for the split in schizophrenia: A twin study perspective. Psychiatric Research 13, 109–118.CrossRefGoogle ScholarPubMed
Goldin, L. R. & Gershon, E. S. (1983). Association and linkage studies of genetic marker loci in major psychiatric disorders. Psychiatric Developments 4, 387–418.Google Scholar
Gottesman, I. I. & Shields, J. (1982). Schizophrenia: The Epigenetic Puzzle. Cambridge University Press: Cambridge.Google Scholar
Green, J. R. & Woodrow, J. C. (1977). Sibling method for detecting HLA-linked genes in disease. Tissue Antigens 9, 31–35.CrossRefGoogle ScholarPubMed
Gurling, H. M. D., Feder, J. & Cavalli-Sforza, L. L. (1984). Molecular genetic investigation into schizophrenia and bipolar disorder: DNA polymorphisms of the gene coding for ACTH, endorphin, CLIP, MSH and LBH. Paper presented at the CINP Congress, 1984.Google Scholar
Gusella, J. F., Wexler, N. S., Conneally, P. M., Naylor, S. L., Anderson, M. A., Tanzi, R. E., Watkins, P. C., Ottina, K., Wallace, M. R., Sakaguchi, A. Y., Young, A. B., Shoulson, I., Bonilla, E. & Martin, J. B. (1983). A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306, 234–238.CrossRefGoogle ScholarPubMed
Hodge, S. E. (1981). Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs. American Journal of Human Genetics 33, 381–395.Google ScholarPubMed
Hodge, S. E. & Spence, M. A. (1981). Some epistatic two-locus models of disease. II. The confounding of linkage and association. American Journal of Human Genetics 22, 396–406.Google Scholar
Kravitz, K., Skolnick, M., Cannings, C., Carmelli, D., Baty, B., Amos, B., Johnson, A., Mendell, N., Edwards, C. & Cartwright, G. (1979). Genetic linkage between haemochromatosis and HLA. American Journal of Human Genetics 31, 601–619.Google ScholarPubMed
Kravitz, K., Skolnick, M., Edwards, C., Cartwright, G., Amos, B., Carmelli, D. & Baty, B. (1978). Pedigree analysis of the linkage between HLA and hemochromatosis. In Genetic Epidemiology (ed. Morton, N. E. and Chung, C. S.), pp. 241–246. Academic Press: New York.Google Scholar
Lange, K., Spence, M. A. & Frank, M. B. (1976). Application of the lod method to the detection and linkage between a quantitative marker: a simulation experiment. American Journal of Human Genetics, 28, 167–173.Google Scholar
McGuffin, P. (1984). Genetic markers in schizophrenia. Ph.D. Thesis: University of London.Google Scholar
McGuffin, P., Farmer, A. E. & Yonace, A. H. (1981). HLA antigens and subtypes of schizophrenia. Psychiatric Research 5, 115–122.CrossRefGoogle ScholarPubMed
McGuffin, P., Festenstein, H. & Murray, R. (1983). A family study of HLA antigens and other genetic markers in schizophrenia. Psychological Medicine 13, 31–43.CrossRefGoogle ScholarPubMed
Maynard-Smith, S., Penrose, L. S. & Smith, C. A. B. (1961). Mathematical Tables for Research Workers in Human Genetics. J. & A. Churchill: London.Google Scholar
Mohr, J. (1951). A search for linkage between the Lutheran blood group and other hereditary characters. Acta Pathologica et Microbiologica Scandinavica 28, 207–210.CrossRefGoogle ScholarPubMed
Morton, N. E. (1955). Sequential tests for the detection of linkage. American Journal of Human Genetics 7, 277–318.Google ScholarPubMed
Morton, N. E. & MacLean, C. J. (1974). Analysis of familial resemblance. III. Complex segregation analysis of quantitative traits. American Journal of Human Genetics 26, 489.Google Scholar
Olaisen, B., Teisberg, P., Jonassen, R., Thorsby, E. & Gedde-Dahl, T. (1983). Gene order and gene distance in the HLA region studied by two haplotype method. Annals of Human Genetics 47, 285–292.CrossRefGoogle Scholar
O'Rourke, D. H., Gottesman, I. I., Suarez, B. K., Rice, J. & Reich, T. (1982). Refutation of the single locus model in the aetiology of schizophrenia. American Journal of Human Genetics 34, 630–649.Google ScholarPubMed
Ott, J. (1974). Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. American Journal of Human Genetics 26, 588–597.Google ScholarPubMed
Ott, J. & Falk, T. (1982). Epistatic association and linkage analysis in human families. Human Genetics 62, 296–300.CrossRefGoogle ScholarPubMed
Penrose, L. S. (1935). The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified parentage. Annals of Eugenics 6, 133–138.CrossRefGoogle Scholar
Riccardi, V. M. (1981). Von Recklinghausen neurofibromatosis. New England Journal of Medicine 305, 1617–1627.CrossRefGoogle ScholarPubMed
Slater, E. (1958). The monogenic theory of schizophrenia. Acta Genetica (Basel) 8, 50–56.Google ScholarPubMed
Smith, C. A. B. (1979). The search for major genetic effects through linkage and association. In Genetic Analysis of Common Diseases: Applications to Predictive Factors in Coronary Disease (ed. Sing, C. F. and Skolnick, M.), pp. 277–295. A. R. Liss: New York.Google Scholar
Smith, S. D., Kimberling, W. J., Pennington, B. F. & Cubs, H. A. (1983). Specific reading disability: identification of an inherited form through linkage analysis. Science 219, 1345–1347.CrossRefGoogle ScholarPubMed
Sturt, E. (1984). Analysis of linkage and association for diseases of genetic aetiology. Statistics in Medicine 3, 57–72.CrossRefGoogle ScholarPubMed
Suarez, B., O'Rourke, D. & Van Eerdewegh, P. (1982). Power of the affected-sib-pair method to detect disease susceptibility loci of small effect: an application to multiple sclerosis. American Journal of Medical Genetics 12, 309–326.CrossRefGoogle ScholarPubMed
Thompson, E. (1978). The number of ancestral genes contributing to a sample of B8 alleles. Nature 272, 288.CrossRefGoogle ScholarPubMed
Thompson, E. A., Kravitz, K., Hill, J. & Skolnick, M. (1978). Linkage and the power of a pedgree structure. In Genetic Epidemiology (ed. Morton, N. E. and Chung, C. S.), pp. 247–253. Academic Press: New York.Google Scholar
Thomson, G. (1981). A review of the theoretical aspects of HLA and disease association. Theoretical Population Biology 20, 168–208.CrossRefGoogle Scholar
Tsuang, M. T., Bucher, K. D. & Fleming, J. A. (1982). Testing the monogenic theory of schizophrenia: an application of segregation analysis to blind family study data. British Journal of Psychiatry 140, 595–599.CrossRefGoogle ScholarPubMed
Weatherall, D. J. (1982). The New Genetics and Clinical Practice. Nuffield Provincial Hospitals Trust: London.Google Scholar
Westerveld, A. & Naylor, S. (1984). Report of the committee on the genetic constitution of chromosomes 18, 19, 20, 21 and 22. Seventh International Workshop on Human Gene Mapping. Cytogenetics and Cell Genetics, 37, Nos. 1–4.CrossRefGoogle Scholar