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Auditory event-related potentials, neurocognition, and global functioning in drug naïve first-episode schizophrenia and bipolar disorder

Published online by Cambridge University Press:  03 September 2021

Xiaojing Li ,
Wei Deng ,
Rui Xue ,
Qiang Wang ,
Hongyan Ren ,
Wei Wei ,
Yamin Zhang ,
Mingli Li ,
Liansheng Zhao  and
Xiangdong Du
...Show all authors
Xiaojing Li
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China
Wei Deng
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China
Rui Xue
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China
Qiang Wang
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China
Hongyan Ren
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China
Wei Wei
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China
Yamin Zhang
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Mingli Li
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China
Liansheng Zhao
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Xiangdong Du
Affiliation:
Suzhou Psychiatry hospital, The Affiliated Guangji Hospital of Soochow University, Jiangsu, China
Yajing Meng
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China
Xiaohong Ma
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Mei-Hua Hall*
Affiliation:
Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, USA
Tao Li*
Affiliation:
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China Mental Health Education Center, Sichuan University, Chengdu, Sichuan, China Suzhou Psychiatry hospital, The Affiliated Guangji Hospital of Soochow University, Jiangsu, China Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
*
Authors for correspondence: Mei-Hua Hall, E-mail: mhall@mclean.harvard.edu; Tao Li, E-mail: litaohx@scu.edu.cn
Authors for correspondence: Mei-Hua Hall, E-mail: mhall@mclean.harvard.edu; Tao Li, E-mail: litaohx@scu.edu.cn
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Abstract

Background

Deficits in event-related potential (ERP) including duration mismatch negativity (MMN) and P3a have been demonstrated widely in chronic schizophrenia (SZ) but inconsistent findings were reported in first-episode patients. Psychotropic medications and diagnosis might contribute to different findings on MMN/P3a ERP in first-episode patients. The present study examined MMN and P3a in first episode drug naïve SZ and bipolar disorder (BPD) patients and explored the relationships among ERPs, neurocognition and global functioning.

Methods

Twenty SZ, 24 BPD and 49 age and sex-matched healthy controls were enrolled in this study. Data of clinical symptoms [Positive and Negative Symptoms Scale (PANSS), Young Manic Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD)], neurocognition [Wechsler Adult Intelligence Scale (WAIS), Cattell's Culture Fair Intelligence Test (CCFT), Delay Matching to Sample (DMS), Rapid Visual Information Processing (RVP)], and functioning [Functioning Assessment Short Test (FAST)] were collected. P3a and MMN were elicited using a passive auditory oddball paradigm.

Results

Significant MMN and P3a deficits and impaired neurocognition were found in both SZ and BPD patients. In SZ, MMN was significantly correlated with FAST (r = 0.48) and CCFT (r = −0.31). In BPD, MMN was significantly correlated with DMS (r = −0.54). For P3a, RVP and FAST scores were significant predictors in SZ, whereas RVP, WAIS and FAST were significant predictors in BPD.

Conclusions

The present study found deficits in MMN, P3a, neurocognition in drug naïve SZ and BPD patients. These deficits appeared to link with levels of higher-order cognition and functioning.

Keywords

Bipolar disorderfirst episode drug naïveMMNP3aschizophrenia
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 3 , February 2023 , pp. 785 - 794
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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