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Associations between P3a and P3b amplitudes and cognition in antipsychotic-naïve first-episode schizophrenia patients

Published online by Cambridge University Press:  19 June 2018

Caitlyn Kruiper ,
Birgitte Fagerlund ,
Mette Ø. Nielsen ,
Signe Düring ,
Maria H. Jensen ,
Bjørn H. Ebdrup ,
Birte Y. Glenthøj  and
Bob Oranje
Caitlyn Kruiper*
Affiliation:
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
Birgitte Fagerlund
Affiliation:
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark
Mette Ø. Nielsen
Affiliation:
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark
Signe Düring
Affiliation:
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark
Maria H. Jensen
Affiliation:
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark
Bjørn H. Ebdrup
Affiliation:
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Birte Y. Glenthøj
Affiliation:
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Bob Oranje
Affiliation:
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
*
Author for correspondence: Caitlyn Kruiper, E-mail: [email protected]
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Abstract

Background

Cognitive deficits are already present in early stages of schizophrenia. P3a and P3b event-related potentials (ERPs) are believed to underlie the processes of attention and working memory (WM), yet limited research has been performed on the associations between these parameters. Therefore, we explored possible associations between P3a/b amplitudes and cognition in a large cohort of antipsychotic-naïve, first-episode schizophrenia (AN-FES) patients and healthy controls (HC).

Methods

Seventy-three AN-FES patients and 93 age- and gender-matched HC were assessed for their P3a/b amplitude with an auditory oddball paradigm. In addition, subjects performed several subtests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).

Results

AN-FES patients had significantly reduced P3a/b amplitudes, as well as significantly lower scores on all cognitive tests compared with HC. Total group correlations revealed positive associations between P3b amplitude and WM and sustained attention and negative associations with all reaction time measures. These associations appeared mainly driven by AN-FES patients, where we found a similar pattern. No significant associations were found between P3b amplitude and cognitive measures in our HC. P3a amplitude did not correlate significantly with any cognitive measures in either group, nor when combined.

Conclusions

Our results provide further evidence for P3a/b amplitude deficits and cognitive deficits in AN-FES patients, which are neither due to antipsychotics nor to disease progress. Furthermore, our data showed significant, yet weak associations between P3b and cognition. Therefore, our data do not supply evidence for deficient P3a/b amplitudes as direct underlying factors for cognitive deficits in schizophrenia.

Keywords

Antipsychotic-naïveattentioncognitionfirst-episode schizophreniapsychophysiologyP3a amplitudeP3b amplitudeworking memory
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 5 , April 2019 , pp. 868 - 875
Copyright
Copyright © Cambridge University Press 2018 

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References

Andersen, R, Fagerlund, B, Rasmussen, H, Ebdrup, BH, Aggernaes, B, Gade, A, Oranje, B and Glenthoj, B (2013) The influence of impaired processing speed on cognition in first-episode antipsychotic naïve schizophrenic patients. European Psychiatry 28, 332–339. doi: Epub 2012 Sep 19.Google Scholar
Atkinson, RJ, Michie, PT and Schall, U (2012) Duration mismatch negativity and P3a in first-episode psychosis and individuals at ultra-high risk of psychosis. Biological Psychiatry 71, 98–104.Google Scholar
Bak, N, Ebdrup, BH, Oranje, B, Fagerlund, B, Jensen, MH, Düring, SW, Nielsen, MØ, Glenthøj, BY and Hansen, LK (2017) Two subgroups of antipsychotic-naïve, first- episode schizophrenia patients identified with a Gaussian mixture model on cognition and electrophysiology. Translational Psychiatry 7, e1087.Google Scholar
Bowie, CR, Reichenberg, A, Patterson, TL, Heaton, RK and Harvey, PD (2006) Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. American Journal of Psychiatry 163, 418–425.Google Scholar
Bramon, E, Rabe-Hesketh, S, Sham, P, Murray, RM and Frangou, S (2004) Meta- analysis of the P300 and P50 waveforms in schizophrenia. Schizophrenia Research 10, 315–329.Google Scholar
Cortiñas, M, Corral, M, Garrido, G, Garolera, M, Pajares, M and Escera, C (2008) Reduced novelty-P3 associated with increased behavioral distractibility in schizophrenia. Biological Psychology 78, 253–260.Google Scholar
del Re, EC, Spencer, KM, Oribe, N, Mesholam-Gately, RI, Goldstein, J, Shenton, ME, Petryshen, T, Seidman, LJ, McCarley, RW and Niznikiewicz, MA (2015) Clinical high- risk and first-episode schizophrenia: auditory event-related potentials. Psychiatry Research: Neuroimaging 231, 126–133.Google Scholar
Devrim-Üҫok, M, Keskin-Ergen, HY and Üҫok, A (2006) Novelty P3 and P3b in first-episode schizophrenia and chronic schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry 30, 1426–1434.Google Scholar
Dichter, GS, van der Stelt, O, Laube Boch, J and Belger, A (2006) Relations among intelligence, executive functioning, and P300 event related potentials in schizophrenia. The Journal of Nervous and Mental Disease 194, 179–187.Google Scholar
Dickinson, D, Ramsey, ME and Gold, JM (2007) Overlooking the obvious. A meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Archives of General Psychiatry 64, 532–542.Google Scholar
Donchin, E (1981) Surprise!… Surprise? Psychophysiology 18, 493–513.Google Scholar
Duncan, CC, Barry, RJ, Connolly, JF, Fischer, C, Michie, PT, Näätänen, R, Polich, J, Reinvang, I and van Petten, C (2009) Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clinical Neurophysiology 120, 1883–1908.Google Scholar
Düring, S, Glenthøj, BY, Andersen, GS and Oranje, B (2014) Effects of dopamine D2/D3 blockade on human sensory and sensorimotor gating in initially antipsychotic-naive, first-episode schizophrenia patients. Neuropsychopharmacology 39(13), 3000–3008.Google Scholar
Guerrero-Pedraza, A, McKenna, P, Gomar, J, Sarró, S, Salvador, R, Amann, B, Carrión, MI, Landin-Romero, R, Blanch, J and Pomarol-Clotet, E (2012) First-episode psychosis is characterized by failure of deactivation but not by hypo- or hyperfrontality. Psychological Medicine 42, 73–84.Google Scholar
Guo, W, Liu, F, Xiao, C, Liu, J, Yu, M, Zhang, Z, Zhang, J and Zhao, J (2015) Increased short- range and long-range functional connectivity in first-episode, medication-naive schizophrenia at rest. Schizophrenia Research 166(1–3), 144–150.Google Scholar
Hartman, M, Steketee, MC, Silva, S, Lanning, K and McCann, H (2003) Working memory and schizophrenia: evidence for slowed encoding. Schizophrenia Research 59, 99–113.Google Scholar
Insel, TR (2010) Rethinking schizophrenia. Nature 468, 187–193.Google Scholar
Jeon, YW and Polich, J (2003) Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. Psychophysiology 40, 684–701.Google Scholar
Jr.Johnson, R (1995) Event-related potential insights into the neurobiology of memory systems. Handbook of Neuropsychology 10, 135–163.Google Scholar
Kahn, R and Keefe, R (2013) Schizophrenia is a cognitive illness. Time for a change in focus. JAMA Psychiatry 70, 1107–1112.Google Scholar
Kay, SR, Opler, LA and Lindenmayer, JP (1988) Reliability and validity of the positive and negative syndrome scale for schizophrenics. Psychiatry Research 23, 99–110.Google Scholar
Keefe, RS, Eesley, CE and Poe, MP (2005) Defining a cognitive function decrement in schizophrenia. Biological Psychiatry 57, 688–691.Google Scholar
Kiehl, KA, Laurens, KR, Duty, TL, Forster, BB and Liddle, PF (2001) Neural sources involved in auditory target detection and novelty processing: an event-related fMRI study. Psychophysiology 38, 133–142.Google Scholar
Kok, A (2001) On the utility of P3 amplitude as a measure of processing capacity. Psychophysiology 38, 557–577.Google Scholar
Kramer, AF and Strayer, DL (1988) Assessing the development of automatic processing: an application of dual-track and event-related brain potential methodologies. Biological Psychology 26, 231–267.Google Scholar
Leucht, S, Kane, JM, Kissling, W, Hamann, J, Etschel, E and Engel, RR (2005) What does the PANSS mean? Schizophrenia Research 79, 231–238.Google Scholar
Lorist, MM, Klein, M, Nieuwenhuis, S, de Jong, R, Mulder, G and Meijman, T (2000) Mental fatigue and task control: planning and preparation. Psychophysiology 37, 614–625.Google Scholar
Lowe, C and Rabbitt, P (1998) Test/re-test reliability of the CANTAB and ISPOCD neuropsychological batteries: theoretical and practical issues. Cambridge Neuropsychological Test Automated Battery. International Study of Post-Operative Cognitive Dysfunction. Neuropsychologia 36, 915–923.Google Scholar
Mathalon, DH, Ford, JM and Pfefferbaum, A (2000) Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Society of Biological Psychiatry 47, 434–449.Google Scholar
Mesholam-Gately, RI, Giuliano, AJ, Goff, KP, Faraone, SV and Seidman, LJ (2009) Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology 23, 315–336.Google Scholar
Mondragón-Maya, A, Solís-Vivanco, R, León-Ortiz, P, Rodríquez-Agudelo, Y, Yánez-Téllez, G, Bernal-Hernández, J, Cadenhead, KS and de la Fuente-Sandoval, C (2013) Reduced P3a amplitudes in antipsychotic naïve first-episode psychosis patients and individuals at clinical high-risk for psychosis. Journal of Psychiatric Research 47, 755–761.Google Scholar
Morales-Muñoz, I, Jurado-Barba, R, Fernández-Guinea, S, Álvarez-Alonso, M, Rodríquez-Jiménez, R, Jiménez-Arriero, MA and Rubio, G (2017) Cognitive impairments in patients with first episode psychosis: the relationship between neurophysiological and neuropsychological assessments. Journal of Clinical Neuroscience 36, 80–87.Google Scholar
Oranje, B, Aggernaes, B, Rasmussen, H, Ebdrup, B and Glenthøj, B (2017) Selective attention and mismatch negativity in antipsychotic-naïve, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy. Psychological Medicine 47, 2155–2165.Google Scholar
Oranje, B, Jensen, KJ, Wienberg, M and Glenthoj, BY (2008) Divergent effects of increased serotonergic activity on psychophysiological parameters of human attention. The International Journal of Neuropsychopharmacology 11, 453–463.Google Scholar
Polich, J (2007) Updating P300: an integrative theory of P3a and P3b. Clinical Neurophysiology 118, 2128–2148.Google Scholar
Portin, R, Kovola, T, Polo-Kantola, P, Revonsuo, A, Müller, K and Matikainen, E (2000) Does P3 reflect attentional or memory performances, or cognition more generally? Scandinavian Journal of Psychology 41, 31–40.Google Scholar
Sahakian, B and Owen, A (1992) Computerized assessment in neuropsychiatry using CANTAB – discussion paper. Journal of the Royal Society of Medicine 85, 399–402.Google Scholar
Salisbury, DF, Shenton, ME, Sherwood, AR, Fischer, IA, Yurgelun-Todd, DA, Tohen, M and McCarley, RW (1998) First-episode schizophrenic psychosis differs from first-episode affective psychosis and controls in P300 amplitude over left temporal lobe. Archives of General Psychiatry 55, 173–180.Google Scholar
Strassnig, MT, Raykov, T, O'Gorman, C, Bowie, CR, Sabbag, S, Durand, D, Patterson, TL, Pinkham, A, Penn, DL and Harvey, PD (2015) Determinants of different aspects of everyday outcome in schizophrenia: the roles of negative symptoms, cognition, and functional capacity. Schizophrenia Research 165, 76–82.Google Scholar
Tam, A, Luedke, AC, Walsh, JJ, Fernandez-Ruiz, J and Garcia, A (2015) Effects of reaction time variability and age on brain activity during Stroop task performance. Brain Imaging and Behavior 9, 609–618.Google Scholar
Thomas, M, Green, M, Hellemann, G, Sugar, C, Tarasenko, M, Calkins, M, Greenwood, T, Gur, R, Gur, R, Lazzeroni, L, Nuechterlein, K, Radant, A, Seidman, L, Shiluk, A, Siever, L, Silverman, J, Sprock, J, Stone, W, Swerdlow, N, Tsuang, D, Tsuang, M, Turetsky, B, Braff, D and Light, G (2017) Modeling deficits from early auditory information processing to psychosocial functioning in schizophrenia. JAMA Psychiatry 74, 37.Google Scholar
Turetsky, BI, Calkins, ME, Light, GA, Olincy, A, Radant, AD and Swerdlow, NR (2007) Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophrenia Bulletin 33, 69–94.Google Scholar
Valkonen-Korhonen, M, Purhonen, M, Tarkka, IM, Sipilä, P, Partanen, J, Karhu, J and Lehtonen, J (2003) Altered auditory processing in acutely psychotic never-medicated first-episode patients. Cognitive Brain Research 17, 747–758.Google Scholar
Wing, JK, Babor, T, Brugha, T, Burke, J, Cooper, JE, Giel, R, Jablenski, A, Regier, D and Sartorius, N (1990) SCAN: schedules for clinical assessment in neuropsychiatry. Archives of General Psychiatry 47, 589–593.Google Scholar
Young, JW, Bismark, AW, Sun, Y, Zhang, W, McIlwain, M, Grootendorst, I and Light, GA (2017) Neurophysiological characterization of attentional performance dysfunction in schizophrenia patients a reverse-translate task. Neuropsychopharmacology 42, 1338–1348.Google Scholar
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