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The association of visuospatial working memory with dysthymic disorder in pre-pubertal children

Published online by Cambridge University Press:  17 July 2009

T. Franklin ,
A. Lee ,
N. Hall ,
S. Hetrick ,
J. Ong ,
N. Haslam ,
F. Karsz  and
A. Vance
T. Franklin
Affiliation:
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, Victoria, Australia
A. Lee
Affiliation:
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, Victoria, Australia
N. Hall
Affiliation:
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, Victoria, Australia
S. Hetrick
Affiliation:
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, Victoria, Australia
J. Ong
Affiliation:
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, Victoria, Australia
N. Haslam
Affiliation:
Department of Psychology, University of Melbourne, Victoria, Australia
F. Karsz
Affiliation:
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, Victoria, Australia
A. Vance*
Affiliation:
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, Victoria, Australia
*
*Address for correspondence: Professor A. Vance, Head, Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia 3052. (Email: [email protected])
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Abstract

Background

Visuospatial working memory (VSWM) deficits have not been investigated specifically in children with dysthymic disorder (DD), although they are associated with impairments in attention that commonly occur in DD. This study investigates VSWM impairment in children with DD.

Method

A cross-sectional study of VSWM in 6- to 12-year-old children with medication-naive DD (n=26) compared to an age-, gender- and ‘performance IQ’ (PIQ)-matched healthy control group (n=28) was completed.

Results

The DD group demonstrated impairment in VSWM, including impairment in the spatial span and strategy components of VSWM. Furthermore, the VSWM impairment remained after controlling for spatial span. Inattentive symptoms were significantly associated with the VSWM impairment.

Conclusions

This study of children with DD found deficits in performance on VSWM tasks, suggesting that fronto-striatal–parietal neural networks that underlie processes of attention and the executive component of VSWM are dysfunctional in children with DD. These findings further our understanding of DD and suggest more specific interventions that might improve functioning.

Keywords

Attentionchildrendysthymic disordervisuospatial working memory
Type
Original Articles
Information
Psychological Medicine , Volume 40 , Issue 2 , February 2010 , pp. 253 - 261
Copyright
Copyright © Cambridge University Press 2009

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References

Achenbach, TM, Edelbrock, CS (1983). Manual for the Child Behavior Checklist and Behavior Profile. University of Vermont: Burlington.Google Scholar
Airaksinen, E, Larsson, M, Lundberg, I, Forsell, Y (2004). Cognitive functions in depressive disorders: evidence from a population-based study. Psychological Medicine 34, 83–91.CrossRefGoogle ScholarPubMed
APA (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th edn, text revision. American Psychiatric Association: Washington, DC.Google Scholar
Awh, E, Jonides, J (1998). Spatial selective attention and spatial working memory. In The Attentive Brain (ed. Parasuraman, R.), pp. 353–380. MIT Press: Cambridge, MA.Google Scholar
Awh, E, Vogel, EK, Oh, SH (2006). Interactions between attention and working memory. Neuroscience 139, 201–208.CrossRefGoogle ScholarPubMed
Baddeley, A (1986). Working Memory. Oxford University Press: New York.Google ScholarPubMed
Barnett, R, Maruff, P, Vance, A (2005). An investigation of visuospatial memory impairment in children with attention deficit hyperactivity disorder (ADHD), combined type. Psychological Medicine 35, 1433–1443.CrossRefGoogle ScholarPubMed
Barnett, R, Maruff, P, Vance, A, Luk, ESL, Costin, J, Wood, C, Pantelis, C (2001). Abnormal executive function in attention deficit hyperactivity disorder: the effect of stimulant medication and age on spatial working memory. Psychological Medicine 31, 1107–1115.CrossRefGoogle ScholarPubMed
Braver, TS, Barch, DM, Kelley, WM, Buckner, RL, Cohen, NJ, Miezen, FM, Snyder, AZ, Ollinger, JM, Akbudak, E, Conturo, TE, Petersen, SE (2001). Direct comparison of prefrontal cortex regions engaged by working and long-term memory tasks. NeuroImage 14, 48–59.CrossRefGoogle ScholarPubMed
Braver, TS, Cohen, JD, Nystrom, LE, Jonides, J, Smith, EE, Noll, DC (1997). A parametric study of prefrontal cortex involvement in human working memory. NeuroImage 5, 49–62.CrossRefGoogle ScholarPubMed
Cairney, S, Maruff, P, Vance, A, Barnett, R, Luk, E, Currie, J (2001). Contextual abnormalities of saccadic inhibition in children with attention deficit hyperactivity disorder. Experimental Brain Research 141, 507–518.CrossRefGoogle ScholarPubMed
Cannon, TD, Glahn, DC, Kim, J, Van Erp, TGM, Karlsgot, K, Cohen, MS, Nuechterlein, KH, Bava, S, Shirinyan, D (2005). Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Archives of General Psychiatry 62, 1071–1080.CrossRefGoogle ScholarPubMed
Carlson, S, Martinkauppi, S, Rama, P, Salli, E, Korvenoja, A, Aronen, HJ (1998). Distribution of cortical activation during visuospatial n-back tasks as revealed by functional magnetic resonance imaging. Cerebral Cortex 8, 743–752.CrossRefGoogle ScholarPubMed
Carmichael, ST, Price, JL (1995). Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys. Journal of Comparative Neurology 363, 615–641.CrossRefGoogle ScholarPubMed
Castellanos, FX, Sonuga-Barke, EJS, Milham, MP, Tannock, R (2006). Characterizing cognition in ADHD: beyond executive dysfunction. Trends in Cognitive Sciences 10, 117–123.CrossRefGoogle ScholarPubMed
Cataldo, MG, Nobile, M, Lorusso, ML, Battaglia, M, Molteni, M (2005). Impulsivity in depressed children and adolescents: a comparison between behavioural and neuropsychological data. Psychiatry Research 136, 123–133.CrossRefGoogle ScholarPubMed
De Luca, CR, Wood, SJ, Anderson, V, Buchanan, J, Proffitt, TM, Mahony, K, Pantelis, C (2003). Normative data from the CANTAB. I: Development of executive function over the lifespan. Journal of Clinical and Experimental Neuropsychology 25, 242–254.CrossRefGoogle ScholarPubMed
D'Esposito, M, Detre, JA, Alsop, DC, Shin, RK, Atlas, S, Grossman, M (1995). The neural basis of the central executive system of working memory. Nature 378, 279–281.CrossRefGoogle ScholarPubMed
Ferro, T, Carlson, GA, Grayson, P, Klein, DN (1994). Depressive disorders: distinction in children. Journal of the American Academy of Child and Adolescent Psychiatry 33, 664–670.CrossRefGoogle ScholarPubMed
Friedman, RA, Markowitz, JC, Parides, M, Kocsis, JH (1995). Acute response of social functioning in dysthymic patients with desiplamine. Journal of Affective Disorders 34, 84–88.CrossRefGoogle Scholar
Goldman-Rakic, PS (1987). Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In Handbook of Physiology: Section 1, The Nervous System, Volume V, Parts 1 and 2: Higher Functions of the Brain (ed. Plum, F.), pp. 373–417. American Physiological Society: Bethesda.Google Scholar
Goldman-Rakic, PS, Selemon, LD (1997). Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophrenia Bulletin 23, 437–458.CrossRefGoogle ScholarPubMed
Haber, SH (2003). The primate basal ganglia: parallel and integrative networks. Journal of Chemical Neuroanatomy 26, 317–330.CrossRefGoogle ScholarPubMed
Kempton, S, Vance, A, Maruff, P, Luk, ESL, Costin, J, Pantelis, C (1999). Executive function and attention deficit hyperactivity disorder: stimulant medication and better executive function performance in children. Psychological Medicine 29, 527–538.CrossRefGoogle ScholarPubMed
Klein, DN, Schwartz, JE, Rose, S, Leader, JB (2000). Five-year course and outcome of dysthymic disorder: a prospective, naturalistic follow-up study. American Journal of Psychiatry 157, 931–939.CrossRefGoogle ScholarPubMed
Kovacs, M (1992). The Children's Depression Inventory. Mental Health Systems: New York.Google Scholar
Kovacs, M, Akiskal, HS, Gatsonis, C, Parrone, PL (1994). Childhood-onset dysthymic disorder: clinical features and prospective naturalistic outcome. Archives of General Psychiatry 51, 365–374.CrossRefGoogle ScholarPubMed
Kovacs, M, Goldston, D (1991). Cognitive and social cognitive-development of depressed children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 30, 388–392.CrossRefGoogle ScholarPubMed
Kravariti, E, Morris, R, Rabe-Hesketh, S, Murray, RM, Frangou, S (2003 a). The Maudsley Early-Onset Schizophrenia Study: cognitive function in recent onset schizophrenia. Schizophrenia Research 61, 137–148.CrossRefGoogle ScholarPubMed
Kravariti, E, Morris, R, Rabe-Hesketh, S, Murray, RM, Frangou, S (2003 b). The Maudsley Early-Onset Schizophrenia Study: cognitive function in adolescent-onset schizophrenia. Schizophrenia Research 65, 95–103.CrossRefGoogle ScholarPubMed
Kyte, ZA, Goodyer, IM, Sahakian, BJ (2005). Selected executive skills in adolescents with recent first episode major depression. Journal of Child Psychology and Psychiatry 46, 995–1005.CrossRefGoogle ScholarPubMed
Lange, KW, Robbins, TW, Marsden, CD, James, M, Owen, AM, Paul, GM (1992). l-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal dysfunction. Psychopharmacology 107, 394–404.CrossRefGoogle Scholar
Lauer, RE, Giordani, B, Boivin, MJ, Halle, N, Glasgow, B, Alessi, NE, Berent, S (1994). Effects of depression on memory performance and metamemory in children. Journal of the American Academy of Child and Adolescent Psychiatry 33, 679–685.CrossRefGoogle ScholarPubMed
Lawrence, AD, Watkins, LHA, Sahakian, BJ, Hodges, JR, Robbins, TW (2000). Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits. Brain 123, 1349–1364.CrossRefGoogle ScholarPubMed
Livingston, RB, Stark, KD, Haak, RA, Jennings, E (1996). Neuropsychological profiles of children with depressive and anxiety disorders. Child Neuropsychology 2, 48–62.CrossRefGoogle Scholar
Luciana, M, Nelson, CA (1998). The functional emergence of prefrontally-guided working memory systems in four- to eight-year-old children. Neuropsychologia 36, 273–293.CrossRefGoogle ScholarPubMed
Martin, DJ, Oren, Z, Boone, K (1991). Major depressives' and dysthymics' performance on the Wisconsin Card Sorting Test. Journal of Clinical Psychology 47, 684–690.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Masi, G, Favilla, L, Mucci, M, Poli, P, Romano, R (2001). Depressive symptoms in children and adolescents with dysthymic disorder. Psychopathology 34, 29–35.CrossRefGoogle ScholarPubMed
Matthews, K, Coghill, D, Rhodes, S (2008). Neuropsychological functioning in depressed adolescent girls. Journal of Affective Disorders, 111, 113–118.CrossRefGoogle ScholarPubMed
Mayberg, HS, Liotti, M, Brannan, SK, McGinnis, S, Mahurin, RK, Jerbek, PA, Silva, JA, Tekell, JL, Martin, CC, Lancaster, JL, Fox, PT (1999). Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry 156, 675–682.CrossRefGoogle ScholarPubMed
Milner, B (1971). Interhemispheric differences in the localisation of psychological processes in man. British Medical Bulletin 27, 272–277.CrossRefGoogle ScholarPubMed
Mitchell, J, McCauley, E, Burke, PM, Moss, SJ (1988). Phenomenology of depression in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 27, 12–20.CrossRefGoogle ScholarPubMed
Owen, AM, Downes, JJ, Sahakian, BJ, Polkey, CE, Robbins, TW (1990). Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28, 1021–1034.CrossRefGoogle ScholarPubMed
Owen, AM, Evans, AC, Petrides, M (1996). Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study. Cerebral Cortex 6, 31–38.CrossRefGoogle ScholarPubMed
Owen, AM, Roberts, AC, Hodges, JR, Summers, BA, Polkey, CE, Robbins, TW (1993). Contrasting mechanisms of attentional set-shifting in patients with frontal lobe damage or Parkinson's disease. Brain 116, 1159–1175.CrossRefGoogle ScholarPubMed
Owen, AM, Sahakian, BJ, Semple, J, Polkey, CE, Robbins, TW (1995). Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologia 33, 1–24.CrossRefGoogle ScholarPubMed
Pantelis, C, Barnes, TRE, Nelson, HE, Tanner, S, Weatherley, L, Owen, AM, Robbins, TW (1997). Fronto-striatal cognitive deficits in patients with chronic schizophrenia. Brain 120, 1823–1843.CrossRefGoogle Scholar
Robbins, TW, James, M, Owen, AM, Sahakian, BJ, McInnes, L, Rabbitt, P (1994). Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers. Dementia 5, 266–281.Google ScholarPubMed
Silverman, WK, Albano, AM (1996). Anxiety Disorders Interview Schedule for DSM-IV. Graywind: Texas.Google Scholar
Smith, EE, Jonides, J, Koeppe, RA (1996). Dissociating verbal and spatial working memory using PET. Cerebral Cortex 96, 11–20.CrossRefGoogle Scholar
Smyth, MM (1996). Interference with rehearsal in spatial working memory in the absence of eye movements. Journal of Experimental Psychology 49, 940–949.Google ScholarPubMed
Tanner, JM (1966). Growth at Adolescence, 2nd edn. Appleton-Century-Crofts: New York, NY.Google Scholar
Vance, A, Arduca, Y, Sanders, M (2005). The associations of oppositional defiant behaviour in children with attention deficit hyperactivity disorder, combined type (ADHD-CT). Journal of Affective Disorders 86, 329–333.CrossRefGoogle ScholarPubMed
Vance, A, Arduca, Y, Sanders, M, Karamitsios, M, Hall, N, Hetrick, S (2006 a). Attention deficit hyperactivity disorder, combined type, dysthymic disorder and anxiety disorders: differential patterns of neurodevelopmental deficits. Psychiatry Research 143, 213–222.CrossRefGoogle ScholarPubMed
Vance, A, Hall, N, Bellgrove, M, Casey, M, Karsz, F (2006 b). Visuospatial working memory deficits in adolescent-onset schizophrenia. Schizophrenia Research 87, 223–227.CrossRefGoogle ScholarPubMed
Vance, AL, Maruff, P, Barnett, R (2003). Attention deficit hyperactivity disorder, combined type: better executive function performance with longer-term psychostimulant medication. Australian and New Zealand Journal of Psychiatry 37, 570–576.CrossRefGoogle ScholarPubMed
Vance, A, Silk, T, Casey, M, Rinehart, N, Bradshaw, J, Bellgrove, M, Cunnington, R (2007). Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study. Molecular Psychiatry 12, 826–832.CrossRefGoogle ScholarPubMed
Wechsler, D (2003). The Wechsler Intelligence Scale for Children – 4th Edition (WISC-IV). The Psychological Corporation: San Antonio, TX.Google Scholar
Wilkinson, GS (1993). Wide Range Achievement Test, 3rd edn. Jastak Assessment Systems: Wilmington, DE.Google Scholar
Williams, D, Stott, CM, Goodyer, IM, Sahakian, BJ (2000). Specific language impairment with or without hyperactivity: neuropsychological evidence for frontostriatal dysfunction. Developmental Medicine and Child Neurology 42, 368–375.CrossRefGoogle ScholarPubMed