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Anorexia nervosa trios: behavioral profiles of individuals with anorexia nervosa and their parents

Published online by Cambridge University Press:  26 June 2008

M. J. Jacobs ,
S. Roesch ,
S. A. Wonderlich ,
R. Crosby ,
L. Thornton ,
D. E. Wilfley ,
W. H. Berrettini ,
H. Brandt ,
S. Crawford  and
M. M. Fichter
...Show all authors
M. J. Jacobs*
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
S. Roesch
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
S. A. Wonderlich
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
R. Crosby
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
L. Thornton
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
D. E. Wilfley
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
W. H. Berrettini
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
H. Brandt
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
S. Crawford
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
M. M. Fichter
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
K. A. Halmi
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
C. Johnson
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
A. S. Kaplan
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
M. LaVia
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
J. E. Mitchell
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
A. Rotondo
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
M. Strober
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
D. B. Woodside
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
W. H. Kaye
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
C. M. Bulik
Affiliation:
University of California, San Diego (UCSD) Eating Disorders Treatment and Research Center, La Jolla, CA, USA
*
*Address for correspondence: M. J. Jacobs, Ph.D., UCSD Eating Disorders Treatment and Research Center, 8950 Villa La Jolla, C-207, La Jolla, CA 92037, USA. (Email: [email protected])
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Abstract

Background

Anorexia nervosa (AN) is associated with behavioral traits that predate the onset of AN and persist after recovery. We identified patterns of behavioral traits in AN trios (proband plus two biological parents).

Method

A total of 433 complete trios were collected in the Price Foundation Genetic Study of AN using standardized instruments for eating disorder (ED) symptoms, anxiety, perfectionism, and temperament. We used latent profile analysis and ANOVA to identify and validate patterns of behavioral traits.

Results

We distinguished three classes with medium to large effect sizes by mothers' and probands' drive for thinness, body dissatisfaction, perfectionism, neuroticism, trait anxiety, and harm avoidance. Fathers did not differ significantly across classes. Classes were distinguished by degree of symptomatology rather than qualitative differences. Class 1 (~33%) comprised low symptom probands and mothers with scores in the healthy range. Class 2 (~43%) included probands with marked elevations in drive for thinness, body dissatisfaction, neuroticism, trait anxiety, and harm avoidance and mothers with mild anxious/perfectionistic traits. Class 3 (~24%) included probands and mothers with elevations on ED and anxious/perfectionistic traits. Mother–daughter symptom severity was related in classes 1 and 3 only. Trio profiles did not differ significantly by proband clinical status or subtype.

Conclusions

A key finding is the importance of mother and daughter traits in the identification of temperament and personality patterns in families affected by AN. Mother–daughter pairs with severe ED and anxious/perfectionistic traits may represent a more homogeneous and familial variant of AN that could be of value in genetic studies.

Keywords

Anorexia nervosaeating disordergeneticstemperament
Type
Original Articles
Information
Psychological Medicine , Volume 39 , Issue 3 , March 2009 , pp. 451 - 461
Copyright
Copyright © 2008 Cambridge University Press

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