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An evaluation of continuation therapy with tricyclic antidepressants in depressive illness1

Published online by Cambridge University Press:  09 July 2009

R. H. S. Mindham ,
C. Howland  and
Michael Shepherd
R. H. S. Mindham
Affiliation:
From the Institute of Psychiatry, London
C. Howland
Affiliation:
Medical Research Council Statistical Research and Services Unit, London
Michael Shepherd
Affiliation:
University College Hospital Medical School, London
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Synopsis

A double-blind clinical trial has been carried out to ascertain whether patients making a good recovery from depressive illness with tricyclic antidepressant medication derive any benefit from continuation of therapy with the same drug at a lower dose level. Of the 92 patients who entered the trial significantly fewer on active treatment relapsed during the six-month trial period: 22% as compared with 50% of patients receiving placebo. Patients with residual symptoms on entry to the trial derived more benefit from continuation therapy than patients who had made a complete recovery. The findings relate to a six-month trial period only, and any possible advantage of continuation therapy over a longer period remains uncertain.

Type
Research Article
Information
Psychological Medicine , Volume 3 , Issue 1 , February 1973 , pp. 5 - 17
Copyright
Copyright © Cambridge University Press 1973

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References

REFERENCES

Armitage, P. (1971). In Statistical Methods in Medical Research. Blackwell: Oxford.Google Scholar
Blashki, T. G., Mowbray, R., and Davies, B. (1971). Controlled trial of amitriptyline in general practice. British Medical Journal, 1, 133–138.CrossRefGoogle ScholarPubMed
Boston Collaborative Drug Surveillance Program (1972). Adverse reactions to the tricyclic-antidepressant drugs. Lancet, 1, 529–531.Google Scholar
Burt, C. G., Gordon, W. F., Holt, N. F., and Hordern, A. (1962). Amitriptyline in depressive states: a controlled trial. Journal of Mental Science, 108, 711–730.CrossRefGoogle ScholarPubMed
Coull, D. C., Crooks, J., Dingwall-Fordyce, I., Scott, A. M., and Weir, R. D. (1970). Amitriptyline and cardiac disease. Lancet, 2, 590–591.CrossRefGoogle ScholarPubMed
Elkes, A. (1969). Mode of Action of Imipramine, MD Thesis, University of London.Google Scholar
Hollister, L. E., Overall, J. E., Shelton, J., Pennington, V., Kimbell, I., and Johnson, M. (1967). Drug therapy of depression. Amitriptyline, perphenazine, and their combination in different syndromes. Archives of General Psychiatry, 17, 486–493.CrossRefGoogle ScholarPubMed
Imlah, N. W., Ryan, E., and Harrington, J. A. (1965). The influence of antidepressant drugs on the response to electroconvulsive therapy and on subsequent relapse rates. Journal of Neuro-Psychophamacology, 4, 438–442.Google Scholar
Kay, D. W. K., Fahy, T., and Garside, R. F. (1970). A seven-month double-blind trial of amitriptyline and diazepam in ECT-treated depressed patients. British Journal of Psychiatry, 117, 667–671.CrossRefGoogle ScholarPubMed
Kuhn, R. (1958). The treatment of depressive states with G 22355 (imipramine hydrochloride). American Journal of Psychiatry, 115, 459–464.CrossRefGoogle Scholar
Leff, J. P., and Wing, J. K. (1971). Trial of maintenance therapy in schizophrenia. British Medical Journal, 3, 599–604.CrossRefGoogle ScholarPubMed
Leyburn, P. (1967). A critical look at antidepressant drug trials. Lancet, 2, 1135–1138.CrossRefGoogle Scholar
Lipsedge, M. S., Rees, W. L., and Pike, D. J. (1971). A double-blind comparison of dothiepin and amitriptyline for the treatment of depression with anxiety. Psychopharmacologia, 19, 153–162.CrossRefGoogle ScholarPubMed
Medical Research Council. (1965). Report by Clinical Psychiatry Committee. Clinical trial of the treatment of depressive illness. British Medical Journal, 1, 881–886.CrossRefGoogle Scholar
Paykel, E. S., Price, J. S., Gillan, R. U., Palmai, G., and Chesser, E. S. (1968). A comparative trial of imipramine and chlorpromazine in depressed patients. British Journal of Psychiatry, 114, 1281–1287.CrossRefGoogle ScholarPubMed
Paykel, E. S., Klerman, G. L., Dimascio, A., Weissman, M. M., and Prusoff, B. A. (1972). In Psychopathology and Psychopharmacology. Edited by Cole, J. O.. John Hopkins Press: Baltimore. (In press.)Google Scholar
Peto, R., and Peto, J. (1972). Asymptotically efficient rank invariant test procedures. Journal of the Royal Statistical Society, Scries B, 135, 185–206.CrossRefGoogle Scholar
Porter, A. M. W. (1970). Depressive illness in a general practice. A demographic study and a controlled trial of imipramine. British Medical Journal, 1, 773–778.CrossRefGoogle Scholar
Porter, A. M. W. (1971). Clinical research in general practice. British Medical Journal, 1, 600–602.CrossRefGoogle ScholarPubMed
Post, F. (1959). Imipramine in depression. British Medical Journal, 2, 1252.CrossRefGoogle Scholar
Seager, C. P., and Bird, R. L. (1962). Imipramine with electrical treatment in depression-controlled trial. Journal of Mental Science, 108, 704–707.CrossRefGoogle ScholarPubMed
Shepherd, M., Lader, M., and Rodnight, R. (1968). Clinical Psychopharmacology. English Universities Press: London.Google Scholar
Wechsler, H., Grosser, G. H., Greenblatt, M. (1965). Research evaluating antidepressant medications on hospitalized mental patients: a survey of published reports during a five-year period. Journal of Nervous and Mental Disease, 141, 231–239.CrossRefGoogle ScholarPubMed
Willcox, D. R. C., Gillan, R., and Hare, E. H. (1965). Do psychiatric out-patients take their drugs? British Medical Journal, 2, 790–792.CrossRefGoogle Scholar
Wilson, J. D., and Enoch, M. D. (1967). Estimation of drug rejection by schizophrenic in-patients, with analysis of clinical factors. British Journal of Psychiatry, 113, 209–211.CrossRefGoogle ScholarPubMed