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Altered emotion regulation in obsessive–compulsive disorder as evidenced by the late positive potential

Published online by Cambridge University Press:  15 September 2015

S. Paul ,
D. Simon ,
T. Endrass  and
N. Kathmann
S. Paul
Affiliation:
Department of Psychology, Humboldt-Universität zu Berlin, Germany
D. Simon*
Affiliation:
Department of Psychology, Humboldt-Universität zu Berlin, Germany
T. Endrass
Affiliation:
Department of Psychology, Humboldt-Universität zu Berlin, Germany Institute of Psychology, Otto-von-Guericke-UniversitätMagdeburg, Germany
N. Kathmann
Affiliation:
Department of Psychology, Humboldt-Universität zu Berlin, Germany
*
*Address for correspondence: D. Simon, Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany. (Email: [email protected])
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Abstract

Background.

Obsessive–compulsive disorder (OCD) is associated with marked anxiety, which triggers repetitive behaviours or mental rituals. The persistence of pathological anxiety and maladaptive strategies to reduce anxiety point to altered emotion regulation. The late positive potential (LPP) is an event-related brain potential (ERP) that reflects sustained attention to emotional stimuli and is sensitive to emotion-regulation instructions. We hypothesized that patients with OCD show altered electrocortical responses during reappraisal of stimuli triggering their symptoms.

Method.

To test our hypothesis, ERPs to disorder-relevant, generally aversive and neutral pictures were recorded while participants were instructed to either maintain or reduce emotional responding using cognitive distraction or cognitive reappraisal.

Results.

Relative to healthy controls, patients with OCD showed enhanced LPPs in response to disorder-relevant pictures, indicating their prioritized processing. While both distraction and reappraisal successfully reduced the LPP in healthy controls, patients with OCD failed to show corresponding LPP modulation during cognitive reappraisal despite successfully reduced subjective arousal ratings.

Conclusions.

The results point to sustained attention towards emotional stimuli during cognitive reappraisal in OCD and suggest that abnormal emotion regulation should be integrated in models of OCD.

Keywords

distractionevent-related potentialslate positive potentialobsessive–compulsive disorderreappraisal
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 1 , January 2016 , pp. 137 - 147
Copyright
Copyright © Cambridge University Press 2015 

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References

Abramowitz, JS, Jacoby, RJ (2015). Obsessive–compulsive and related disorders: a critical review of the new diagnostic class. Annual Review of Clinical Psychology 11, 165–186.Google Scholar
Adler, CM, McDonough-Ryan, P, Sax, KW, Holland, SK, Arndt, S, Strakowski, SM (2000). fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder. Journal of Psychiatric Research 34, 317–324.Google Scholar
Alpers, GW, Gerdes, AB, Lagarie, B, Tabbert, K, Vaitl, D, Stark, R (2009). Attention and amygdala activity: an fMRI study with spider pictures in spider phobia. Journal of Neural Transmission 116, 747–757.Google Scholar
American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Publishing: Arlington, VA.Google Scholar
Ball, TM, Ramsawh, HJ, Campbell-Sills, L, Paulus, MP, Stein, MB (2013). Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders. Psychological Medicine 43, 1475–1486.Google Scholar
Bar-Haim, Y, Lamy, D, Pergamin, L, Bakermans-Kranenburg, MJ, van IJzendoorn, MH (2007). Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychological Bulletin 133, 1–24.Google Scholar
Beck, A, Steer, R, Brown, G (1996). Manual for the Beck Depression Inventory-II. Psychological Corporation: San Antonio, TX.Google Scholar
Berg, P, Scherg, M (1994). A multiple source approach to the correction of eye artifacts. Electroencephalography and Clinical Neurophysiology 90, 229–241.Google Scholar
Berking, M, Wupperman, P (2012). Emotion regulation and mental health: recent findings, current challenges, and future directions. Current Opinion in Psychiatry 25, 128–134.CrossRefGoogle ScholarPubMed
Beucke, JC, Sepulcre, J, Talukdar, T, Linnman, C, Zschenderlein, K, Endrass, T, Kaufmann, C, Kathmann, N (2013). Abnormally high degree connectivity of the orbitofrontal cortex in obsessive–compulsive disorder. JAMA Psychiatry 70, 619–629.Google Scholar
Calkins, AW, Berman, NC, Wilhelm, S (2013). Recent advances in research on cognition and emotion in OCD: a review. Current Psychiatry Reports 15, 357.Google Scholar
Clark, DA (2004). Cognitive–Behavioral Therapy for OCD. Guilford Press: New York.Google Scholar
de la Cruz, LF, Landau, D, Iervolino, AC, Santo, S, Pertusa, A, Singh, S, Mataix-Cols, D (2013). Experiential avoidance and emotion regulation difficulties in hoarding disorder. Journal of Anxiety Disorders 27, 204–209.Google Scholar
Dörfel, D, Lamke, J-P, Hummel, F, Wagner, U, Erk, S, Walter, H (2014). Common and differential neural networks of emotion regulation by detachment, reinterpretation, distraction, and expressive suppression: a comparative fMRI investigation. NeuroImage 101, 298–309.Google Scholar
Fellows, LK, Farah, MJ (2003). Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm. Brain 126, 1830–1837.Google Scholar
Foa, EB, Huppert, JD, Leiberg, S, Langner, R, Kichic, R, Hajcak, G, Salkovskis, PM (2002). The Obsessive–Compulsive Inventory: development and validation of a short version. Psychological Assessment 14, 485–496.Google Scholar
Garnefski, N, Kraaij, V, Spinhoven, P (2001). Negative life events, cognitive emotion regulation and emotional problems. Personality and Individual Differences 30, 1311–1327.Google Scholar
Goldin, PR, Manber, T, Hakimi, S, Canli, T, Gross, JJ (2009). Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat. Archives of General Psychiatry 66, 170–180.Google Scholar
Goodman, WK, Price, LH, Rasmussen, SA, Mazure, C, Fleischmann, RL, Hill, CL, Heninger, GR, Charney, DS (1989). The Yale–Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Archives of General Psychiatry 46, 1006–1011.Google Scholar
Gottfried, JA, O'Doherty, J, Dolan, RJ (2003). Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science 301, 1104–1107.Google Scholar
Gross, JJ (1998). Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. Journal of Personality and Social Psychology 74, 224.Google Scholar
Gross, JJ, John, OP (2003). Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. Journal of Personality and Social Psychology 85, 348–362.Google Scholar
Gross, JJ, Muñoz, RF (1995). Emotion regulation and mental health. Clinical Psychology: Science and Practice 2, 151–164.Google Scholar
Hajcak, G, MacNamara, A, Olvet, DM (2010). Event-related potentials, emotion, and emotion regulation: an integrative review. Developmental Neuropsychology 35, 129–155.Google Scholar
Hajcak, G, Nieuwenhuis, S (2006). Reappraisal modulates the electrocortical response to unpleasant pictures. Cognitive, Affective, and Behavioral Neuroscience 6, 291–297.CrossRefGoogle ScholarPubMed
Hermann, A, Schafer, A, Walter, B, Stark, R, Vaitl, D, Schienle, A (2009). Emotion regulation in spider phobia: role of the medial prefrontal cortex. Social Cognitive and Affective Neuroscience 4, 257–267.Google Scholar
Holzschneider, K, Mulert, C (2011). Neuroimaging in anxiety disorders. Dialogues in Clinical Neuroscience 13, 453–461.Google Scholar
Kanske, P, Heissler, J, Schönfelder, S, Bongers, A, Wessa, M (2011). How to regulate emotion? Neural networks for reappraisal and distraction. Cerebral Cortex 21, 1379–1388.Google Scholar
Kanske, P, Heissler, J, Schönfelder, S, Wessa, M (2012). Neural correlates of emotion regulation deficits in remitted depression: the influence of regulation strategy, habitual regulation use, and emotional valence. NeuroImage 61, 686–693.Google Scholar
Kolassa, IT, Musial, F, Mohr, A, Trippe, RH, Miltner, WH (2005). Electrophysiological correlates of threat processing in spider phobics. Psychophysiology 42, 520–530.Google Scholar
Kret, ME, Ploeger, A (2015). Emotion processing deficits: a liability spectrum providing insight into comorbidity of mental disorders. Neuroscience and Biobehavioral Reviews 52, 153–171.Google Scholar
Kringelbach, ML, Rolls, ET (2003). Neural correlates of rapid reversal learning in a simple model of human social interaction. NeuroImage 20, 1371–1383.Google Scholar
Lang, PJ, Bradley, MM, Cuthbert, BN (2008). International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual. Technical Report A-8. University of Florida: Gainesville, FL.Google Scholar
Leutgeb, V, Schafer, A, Schienle, A (2009). An event-related potential study on exposure therapy for patients suffering from spider phobia. Biological Psychology 82, 293–300.Google Scholar
Leutgeb, V, Schafer, A, Schienle, A (2011). Late cortical positivity and cardiac responsitivity in female dental phobics when exposed to phobia-relevant pictures. International Journal of Psychophysiology 79, 410–416.Google Scholar
Liu, Y, Huang, H, McGinnis-Deweese, M, Keil, A, Ding, M (2012). Neural substrate of the late positive potential in emotional processing. Journal of Neuroscience 32, 14563–14572.Google Scholar
MacNamara, A, Hajcak, G (2009). Anxiety and spatial attention moderate the electrocortical response to aversive pictures. Neuropsychologia 47, 2975–2980.Google Scholar
McRae, K, Ciesielski, B, Gross, JJ (2012). Unpacking cognitive reappraisal: goals, tactics, and outcomes. Emotion 12, 250–255.CrossRefGoogle ScholarPubMed
Michalowski, JM, Melzig, CA, Weike, AI, Stockburger, J, Schupp, HT, Hamm, AO (2009). Brain dynamics in spider-phobic individuals exposed to phobia-relevant and other emotional stimuli. Emotion 9, 306–315.Google Scholar
Milad, MR, Rauch, SL (2012). Obsessive–compulsive disorder: beyond segregated cortico-striatal pathways. Trends in Cognitive Sciences 16, 43–51.Google Scholar
Montgomery, SA, Åsberg, M (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry 134, 382–389.Google Scholar
Moser, JS, Krompinger, JW, Dietz, J, Simons, RF (2009). Electrophysiological correlates of decreasing and increasing emotional responses to unpleasant pictures. Psychophysiology 46, 17–27.Google Scholar
Murray, EA, O'Doherty, JP, Schoenbaum, G (2007). What we know and do not know about the functions of the orbitofrontal cortex after 20 years of cross-species studies. Journal of Neuroscience 27, 8166–8169.Google Scholar
Norberg, J, Peira, N, Wiens, S (2010). Never mind the spider: late positive potentials to phobic threat at fixation are unaffected by perceptual load. Psychophysiology 47, 1151–1158.Google ScholarPubMed
Ochsner, KN, Gross, JJ (2007). The neural architecture of emotion regulation. In Handbook of Emotion Regulation (ed. Gross, J. J. and Buck, R.), pp. 87–109. Guilford Press: New York.Google Scholar
Paul, S, Simon, D, Kniesche, R, Kathmann, N, Endrass, T (2013). Timing effects of antecedent- and response-focused emotion regulation strategies. Biological Psychology 94, 136–142.Google Scholar
Pauls, DL, Abramovitch, A, Rauch, SL, Geller, DA (2014). Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective. Nature Reviews Neuroscience 15, 410–424.Google Scholar
Phillips, ML, Drevets, WC, Rauch, SL, Lane, R (2003). Neurobiology of emotion perception II: implications for major psychiatric disorders. Biological Psychiatry 54, 515–528.Google Scholar
Remijnse, PL, Nielen, MM, Uylings, HB, Veltman, DJ (2005). Neural correlates of a reversal learning task with an affectively neutral baseline: an event-related fMRI study. NeuroImage 26, 609–618.Google Scholar
Remijnse, PL, Nielen, MM, van Balkom, AJ, Cath, DC, van Oppen, P, Uylings, HB, Veltman, DJ (2006). Reduced orbitofrontal–striatal activity on a reversal learning task in obsessive–compulsive disorder. Archives of General Psychiatry 63, 1225–1236.Google Scholar
Remijnse, PL, Nielen, MM, van Balkom, AJ, Hendriks, GJ, Hoogendijk, WJ, Uylings, HB, Veltman, DJ (2009). Differential frontal–striatal and paralimbic activity during reversal learning in major depressive disorder and obsessive–compulsive disorder. Psychological Medicine 39, 1503–1518.Google Scholar
Roy, M, Shohamy, D, Wager, TD (2012). Ventromedial prefrontal–subcortical systems and the generation of affective meaning. Trends in Cognitive Sciences 16, 147–156.Google Scholar
Rudebeck, PH, Saunders, RC, Prescott, AT, Chau, LS, Murray, EA (2013). Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating. Nature Neuroscience 16, 1140–1145.Google Scholar
Sabatinelli, D, Keil, A, Frank, DW, Lang, PJ (2013). Emotional perception: correspondence of early and late event-related potentials with cortical and subcortical functional MRI. Biological Psychology 92, 513–519.CrossRefGoogle ScholarPubMed
Salkovskis, PM (1985). Obsessional–compulsive problems: a cognitive-behavioural analysis. Behaviour Research and Therapy 23, 571–583.Google Scholar
Saxena, S, Brody, AL, Schwartz, JM, Baxter, LR (1998). Neuroimaging and frontal–subcortical circuitry in obsessive–compulsive disorder. British Journal of Psychiatry Supplements, issue 35, 26–37.CrossRefGoogle ScholarPubMed
Saxena, S, Rauch, SL (2000). Functional neuroimaging and the neuroanatomy of obsessive–compulsive disorder. Psychiatric Clinics of North America 23, 563–586.Google Scholar
Schienle, A, Kochel, A, Leutgeb, V (2011). Frontal late positivity in dental phobia: a study on gender differences. Biological Psychology 88, 263–269.Google Scholar
Schienle, A, Schäfer, A, Naumann, E (2008). Event-related brain potentials of spider phobics to disorder-relevant, generally disgust- and fear-inducing pictures. Journal of Psychophysiology 22, 5–13.Google Scholar
Schönfelder, S, Kanske, P, Heissler, J, Wessa, M (2014). Time course of emotion-related responding during distraction and reappraisal. Social Cognitive and Affective Neuroscience 9, 1310–1319.Google Scholar
Schupp, HT, Cuthbert, BN, Bradley, MM, Hillman, CH, Hamm, AO, Lang, PJ (2004). Brain processes in emotional perception: motivated attention. Cognition and Emotion 18, 593–611.CrossRefGoogle Scholar
Simon, D, Adler, N, Kaufmann, C, Kathmann, N (2014). Amygdala hyperactivation during symptom provocation in obsessive–compulsive disorder and its modulation by distraction. NeuroImage: Clinical 4, 549–557.Google Scholar
Simon, D, Kaufmann, C, Musch, K, Kischkel, E, Kathmann, N (2010). Fronto-striato-limbic hyperactivation in obsessive–compulsive disorder during individually tailored symptom provocation. Psychophysiology 47, 728–738.Google Scholar
Simon, D, Kischkel, E, Spielberg, R, Kathmann, N (2012). A pilot study on the validity of using pictures and videos for individualized symptom provocation in obsessive–compulsive disorder. Psychiatry Research 198, 81–88.CrossRefGoogle ScholarPubMed
Spielberger, CD (1983). Manual for the State-Trait Anxiety Inventory STAI. Consulting Psychologists Press: Palo Alto, CA.Google Scholar
Straube, T, Lipka, J, Sauer, A, Mothes-Lasch, M, Miltner, WH (2011). Amygdala activation to threat under attentional load in individuals with anxiety disorder. Biology of Mood and Anxiety Disorders 1, 12.Google Scholar
Straube, T, Mentzel, HJ, Miltner, WH (2006). Neural mechanisms of automatic and direct processing of phobogenic stimuli in specific phobia. Biological Psychiatry 59, 162–170.CrossRefGoogle ScholarPubMed
Tanaka-Matsumi, J, Kameoka, VA (1986). Reliabilities and concurrent validities of popular self-report measures of depression, anxiety, and social desirability. Journal of Consulting and Clinical Psychology 54, 328.Google Scholar
Thiruchselvam, R, Blechert, J, Sheppes, G, Rydstrom, A, Gross, JJ (2011). The temporal dynamics of emotion regulation: an EEG study of distraction and reappraisal. Biological Psychology 87, 84–92.CrossRefGoogle ScholarPubMed
Thiruchselvam, R, Hajcak, G, Gross, JJ (2012). Looking inward: shifting attention within working memory representations alters emotional responses. Psychological Science 23, 1461–1466.CrossRefGoogle ScholarPubMed
Wangelin, BC, Low, A, McTeague, LM, Bradley, MM, Lang, PJ (2011). Aversive picture processing: effects of a concurrent task on sustained defensive system engagement. Psychophysiology 48, 112–116.Google Scholar
Weinberg, A, Hajcak, G (2010). Beyond good and evil: the time-course of neural activity elicited by specific picture content. Emotion 10, 767–782.Google Scholar
Wiens, S, Syrjanen, E (2013). Directed attention reduces processing of emotional distracters irrespective of valence and arousal level. Biological Psychology 94, 44–54.Google Scholar
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