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Adrenal secretion and major depression in 8- to 16-year-olds, II. Influence of co-morbidity at presentation

Published online by Cambridge University Press:  09 July 2009

J. Herbert ,
I. M. Goodyer ,
P. M. E. Altham ,
J. Pearson ,
S. M. Secher  and
H. M. Shiers
J. Herbert
Affiliation:
Developmental Psychiatry Section, Department of Psychiatry, Department of Anatomy, MRC Cambridge Centre for Brain Repair and the Statistical Laboratory, University of Cambridge
I. M. Goodyer*
Affiliation:
Developmental Psychiatry Section, Department of Psychiatry, Department of Anatomy, MRC Cambridge Centre for Brain Repair and the Statistical Laboratory, University of Cambridge
P. M. E. Altham
Affiliation:
Developmental Psychiatry Section, Department of Psychiatry, Department of Anatomy, MRC Cambridge Centre for Brain Repair and the Statistical Laboratory, University of Cambridge
J. Pearson
Affiliation:
Developmental Psychiatry Section, Department of Psychiatry, Department of Anatomy, MRC Cambridge Centre for Brain Repair and the Statistical Laboratory, University of Cambridge
S. M. Secher
Affiliation:
Developmental Psychiatry Section, Department of Psychiatry, Department of Anatomy, MRC Cambridge Centre for Brain Repair and the Statistical Laboratory, University of Cambridge
H. M. Shiers
Affiliation:
Developmental Psychiatry Section, Department of Psychiatry, Department of Anatomy, MRC Cambridge Centre for Brain Repair and the Statistical Laboratory, University of Cambridge
*
1Address for correspondence: Professor I. M. Goodyer, Development Psychiatry Section, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH.
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Synopsis

The association between high evening cortisol and low morning DHEA and the pattern of co-morbid diagnoses in 82 cases of major depressive disorder in 8- to 16-year-olds has been analysed. There was a significant association between the presence of high evening cortisol and co-morbid dysthymia. This was independent of age or sex. No positive association was found between the presence of low morning DHEA and any co-morbid diagnosis. However, co-morbid panic or phobic disorder was significantly associated with the absence of this endocrine abnormality. These findings suggest that specific endocrine disturbances may be associated with different patterns of co-morbidity during an episode of major depression in this age group.

Type
Original Articles
Information
Psychological Medicine , Volume 26 , Issue 2 , March 1996 , pp. 257 - 263
Copyright
Copyright © Cambridge University Press 1996

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