Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-12-03T19:15:38.564Z Has data issue: false hasContentIssue false
  • English
  • Français

Acute effects of diphenylhydantoin in relation to plasma levels1: Behavioural and psychophysiological studies

Published online by Cambridge University Press:  09 July 2009

C.-M. Ideström ,
D. Schalling ,
U. Carlquist  and
F. Sjöqvist
C.-M. Ideström
Affiliation:
Departments of Experimental Psychiatry, Forensic Psychiatry, and Pharmacology (Division of Clinical Pharmacology), Karolinska Institute, Stockholm, Sweden
D. Schalling
Affiliation:
Departments of Experimental Psychiatry, Forensic Psychiatry, and Pharmacology (Division of Clinical Pharmacology), Karolinska Institute, Stockholm, Sweden
U. Carlquist
Affiliation:
Departments of Experimental Psychiatry, Forensic Psychiatry, and Pharmacology (Division of Clinical Pharmacology), Karolinska Institute, Stockholm, Sweden
F. Sjöqvist
Affiliation:
Departments of Experimental Psychiatry, Forensic Psychiatry, and Pharmacology (Division of Clinical Pharmacology), Karolinska Institute, Stockholm, Sweden
Get access Rights & Permissions [Opens in a new window]

Synopsis

Two double-blind experiments are reported in which different doses of diphenylhydantoin were compared with placebo. Drug effects on tests, psychophysiological measures, and self-ratings of mood were studied in normal subjects and related to plasma levels of the drug and psychasthenic personality traits. Significant sedative effects were obtained in some self-rating variables. The combined effect in the objective psychological tests was significantly correlated (rank) to the plasma level in the higher dose experiment.

Type
Research Article
Information
Psychological Medicine , Volume 2 , Issue 2 , May 1972 , pp. 111 - 120
Copyright
Copyright © Cambridge University Press 1972

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Alexanderson, B., Evans, D. A. P., and Sjöqvist, F. (1969). Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy. British Medical Journal, 4, 764–768.CrossRefGoogle ScholarPubMed
Åsberg, M., Cronholm, B., Sjöqvist, F., and Tuck, D. (1970). Correlation of subjective side effects with plasma concentrations of nortriptyline. British Medical Journal, 4, 18–21.CrossRefGoogle ScholarPubMed
Berry, R., and Turner, P. (1968). The pathology of a crossover trial (Thiazesim—a new antidepressant drug). British Journal of Psychiatry, 114, 203–206.CrossRefGoogle Scholar
Booker, H. E., Matthews, C. G., and Slaby, A. (1967). Effects of diphenylhydantoin on selected physiological and psychological measures in normal adults. Neurology, 17, 949–951.CrossRefGoogle ScholarPubMed
Borgå, O., Azarnoff, D. L., Forshell, G. P., and Sjöqvist, F. (1969). Plasma protein binding of tricyclic antidepressants in man. Biochemical Pharmacology, 18, 2135–2143.CrossRefGoogle ScholarPubMed
Buchthal, F., Svensmark, O., and Schiller, P. J. (1960). Clinical and electroencephalographic correlations with serum levels of diphenylhydantoin. Archives of Neurology, 2, 624–630.CrossRefGoogle Scholar
Coppen, A. (1966). The Marke-Nyman temperament scale: an English translation. British Journal of Medical Psychology, 39, 55–59.CrossRefGoogle ScholarPubMed
Dill, W. A., Kazenko, A., Wolf, L. M., and Glazko, A. J. (1956). Studies on 5,5-diphenylhydantoin (Dilantin) in animals and man. Journal of Pharmacology and Experimental Therapeutics, 118, 270–279.Google Scholar
Essig, C. F. (1969). The potential risk of addiction to non-barbiturate sedative and minor tranquilizing drugs. In Abuse of Central Stimulants. Symposium arranged by the Swedish Committee on International Health Relations, Stockholm, November 25–27, 1968. pp. 89–112. Edited by Sjöqvist, F. and Tottie, M.. Almqvist & Wilksell: Stockholm.Google Scholar
Frankenhaeuser, M., and Post, B. (1966). Objective and subjective performance as influenced by drug-induced variations in activation level. Scandinavian Journal of Psychology, 7, 168–178.CrossRefGoogle ScholarPubMed
Freyschuss, U., Sjöqvist, F., and Tuck, D. (1970). Tyramine pressor effects in man before and during treatment with nortriptyline or ECT: correlation between plasma level and effect of nortriptyline. Pharmacologia Clinica, 2, 72–78.CrossRefGoogle Scholar
Hammer, W., Ideström, C.-M., and Sjöqvist, F. (1967). Chemical control of antidepressant drug therapy. In Proceedings of the First International Symposium, Milan, 1966. Edited by Garattini, S. and Dukes, M. N. G.. International Congress Series No. 122, 301–310. Excerpta Medica Foundation: Amsterdam.Google Scholar
Hare, R. D. (1968). Detection threshold for electric shock in psychopaths. Journal of Abnormal Psychology, 73, 268–272.CrossRefGoogle ScholarPubMed
Ideström, C.-M. (1960). Experimental psychologic methods applied in psychopharmacology. Acta Psychiatrica et Neurologica Scandinavica, 35, 302–313.CrossRefGoogle ScholarPubMed
Ideström, C.-M., and Schalling, D. (1970). Objective effects of dexamphetamine and amobarbital and their relations to psychasthenic personality traits. Psychopharmacologia (Berlin), 17, 399–413.CrossRefGoogle ScholarPubMed
Janke, W. (1964). Experimentelle Untersuchungen zur Abhängigkeit der Wirkung psychotroper Substanzen von Persönlichkeitsmerkmalen. Akademische Verlagsgesellschaft: Frankfurt am Main.Google Scholar
Jensen, A. R., and Rohwer, W. D. Ø. (1966). The Stroop color-word test: a review. Acta Psychologica, 25, 36–93.CrossRefGoogle ScholarPubMed
Jonas, A. D. (1967). The diagnostic and therapeutic use of diphenylhydantoin in the subictal state and non-epileptic dysphoria. International Journal of Neuropsychiatry, 3, Supplement No. 2, S21–29.Google ScholarPubMed
Kutt, H., Haynes, J., and McDowell, F. (1966). Some causes of ineffectiveness of diphenylhydantoin. Archives of Neurology, 14, 489–492.CrossRefGoogle ScholarPubMed
Kutt, H., Winters, W., Kokenge, R., and McDowell, F. (1964). Diphenylhydantoin metabolism, blood levels, and toxicity. Archives of Neurology, 11, 642–648.CrossRefGoogle ScholarPubMed
Lader, M. H., and Wing, L. (1966). Physiological Measures, Sedative Drugs and Morbid Anxiety. Maudsley Monograph No. 14. Oxford University Press: London.Google Scholar
Lefkowitz, M. M. (1969). Effects of diphenylhydantoin on disruptive behavior. Study of male delinquents. Archives of General Psychiatry, 20, 643–651.CrossRefGoogle ScholarPubMed
Nyman, G. E., and Marke, S. (1962). Sjöbrings Differentiella Psykologi. Gleerups: Lund.Google Scholar
Resnick, O. (1967). The psychoactive properties of diphenylhydantoin: experiences with prisoners and juvenile delinquents. International Journal of Neuropsychiatry, 3, Supplement No. 2, S30–36.Google ScholarPubMed
Schalling, D., and Holmberg, M. (1970). Extraversion in criminals and the ‘dual nature’ of extraversion. Comments based en results obtained by inventories. Reports from the Psychological Laboratories, University of Stockholm, No. 306.Google Scholar
Sjöqvist, F., Hammer, W., Borgä, O., and Azarnoff, D. L. (1969). Pharmacological significance of the plasma level of monomethylated tricyclic antidepressants. In Proceedings of the VI International Congress of the Colloquium Internationale Neuro-Psychopharmacologicum, Tarragona, 1968. International Congress Series No. 180, 128–136. Excerpta Medica Foundation: Amsterdam.Google Scholar
Sjöqvist, F., Hammer, W., Ideström, C.-M., Lind, M., Tuck, D., and Åsberg, M. (1968). Plasma level of monomethylated tricyclic antidepressants and side-effects in man. In Proceedings of the European Society for Study of Drug Toxicity, Paris, 1967. Vol. 9, 1968. International Congress Series No. 145, 246–257. Excerpta Medica Foundation: Amsterdam.Google Scholar
Stephens, J. H., and Shaffer, J. W. (1970). A controlled study of the effects of diphenylhydantoin on anxiety, irritability and anger in neurotic outpatients. Psycliopharmacologia (Berlin), 17, 169–181.CrossRefGoogle ScholarPubMed
Thurstone, L. L., and Mellinger, J. J. (1953). The Stroop test. Psychometric Laboratory, University of North Carolina, no. 3. Chapel Hill: N.C.Google Scholar
Toman, J. E. P. (1965). Drugs effective in convulsive disorders. In The Pharmacological Basis of Therapeutics, 3rd edn, pp. 215–236. Edited by Goodman, L. S. and Gilman, A.. Macmillan: New York.Google Scholar
Turner, W. J. (1967). The usefulness of diphenylhydantoin in treatment of non-epileptic emotional disorders. International Journal of Neuropsychiatry, 3, Supplement No. 2, 8–20.Google ScholarPubMed