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Acetylator status and inhibition of platelet monoamine oxidase following treatment with pheneizine

Published online by Cambridge University Press:  09 July 2009

Celia M. Yates  and
J. B. Loudon
Celia M. Yates*
Affiliation:
MRC Brain Metabolism Unit, Department of Pharmacology, University of Edinburgh
J. B. Loudon
Affiliation:
MRC Brain Metabolism Unit, Department of Pharmacology, University of Edinburgh
*
1Address for correspondence: Dr Celia M. Yates, MRC Brain Metabolism Unit, University Department of Pharmacology, I George Square, Edinburgh EH8 9JZ.
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Synopsis

The activity of platelet monoamine oxidase(MAO)was measured in 22 severely depressed patients before and after treatment with 45 mg and 60 mg phenelzine. The per cent inhibition of platelet MAO after both doses was not related to acetylator status.

Phenelzine, since it is a hydrazine derivative, is probably metabolized by polymorphic acetylation. Patients who were phenotypically slow acetylators have been reported to show a better clinical response (Johnstone & Marsh, 1973) and more side-effects (Evans et al. 1965) to a given dose of phenelzine than patients who were fast acetylators.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 9 , Issue 4 , November 1979 , pp. 777 - 779
Copyright
Copyright © Cambridge University Press 1979

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