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A study of genetic linkage in schizophrenia

Published online by Cambridge University Press:  09 July 2009

B. Andrew ,
D. C. Watt ,
C. Gillespie  and
H. Chapel
B. Andrew
Affiliation:
St John's Hospital, Stone, Aylesbury
D. C. Watt*
Affiliation:
St John's Hospital, Stone, Aylesbury
C. Gillespie
Affiliation:
St John's Hospital, Stone, Aylesbury
H. Chapel
Affiliation:
St John's Hospital, Stone, Aylesbury
*
1Address for correspondence: Dr D. C. Watt, 7 Churchway, Stone, Aylesbury, Bucks HP17 8RG.
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Synopsis

Families with more than one member affected by schizophrenia were identified and their members were interviewed. Four standardized diagnostic definitions (PSE, DSM-III, ICD-9, Feighner) were applied to all subjects who were classified as schizophrenic or not schizophrenic according to each definition. Non-schizophrenic psychiatric disorders which have been shown to be familially associated with schizophrenia were also identified. Twenty blood markers were ascertained for all subjects and evidence of co-segregation with schizophrenia was sought. No selective segregation was found and therefore there was no evidence suggesting linkage or supporting a monogenic theory of transmission of susceptibility to schizophrenia.

Type
Research Article
Information
Psychological Medicine , Volume 17 , Issue 2 , May 1987 , pp. 363 - 370
Copyright
Copyright © Cambridge University Press 1987

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