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Set-shifting ability across the spectrum of eating disorders and in overweight and obesity: a systematic review and meta-analysis

Published online by Cambridge University Press:  26 February 2014

M. Wu ,
T. Brockmeyer ,
M. Hartmann ,
M. Skunde ,
W. Herzog  and
H.-C. Friederich
M. Wu
Affiliation:
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany
T. Brockmeyer*
Affiliation:
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany
M. Hartmann
Affiliation:
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany
M. Skunde
Affiliation:
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany
W. Herzog
Affiliation:
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany
H.-C. Friederich
Affiliation:
Department of General Internal Medicine and Psychosomatics, University of Heidelberg, Germany
*
*Address for correspondence: T. Brockmeyer, Ph.D., Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. (Email: [email protected])
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Abstract

Background.

In this meta-analysis we review the findings from neuropsychological studies on set-shifting in people with eating disorders (EDs) or overweight/obesity.

Method.

Four databases (PubMed, PsycINFO, PSYNDEX and Web of Science) were searched for eligible studies. Effect sizes (ESs) were pooled using random-effects models. Moderator analyses were conducted for ED and overweight/obese subgroups, adult/adolescent samples and measures of set-shifting.

Results.

Sixty-four studies with a total of 1825 ED patients [1394 anorexia nervosa (AN), 376 bulimia nervosa (BN) and 55 binge eating disorder (BED)] and 10 studies with a total of 449 overweight/obese individuals were included. The meta-analysis revealed a small to medium ES for inefficient set-shifting across all three ED diagnoses (Hedges’ g = –0.45). Subgroup analyses yielded small to medium ESs for each ED subtype (g = –0.44 for AN, –0.53 for BED, –0.50 for BN), which did not differ significantly. There was a medium ES for restricting type AN (ANR; g = –0.51) but no significant ES for binge/purge type AN (AN/BP; g = –0.18). A medium ES was found across obesity studies (g = –0.61). The ES across overweight studies was not significant (g = –0.07). Adult samples did not differ from adolescent samples in either ED or overweight/obesity studies. The different set-shifting measures were associated with largely varying ESs.

Conclusions.

The meta-analysis provides strong support that inefficient set-shifting is a salient neuropsychological phenomenon across ED subtypes and obesity, but is less prominent in AN/BP and overweight. Compulsivity seems to be a common underlying factor supporting a dimensional and transdiagnostic conceptualization of EDs and obesity.

Keywords

Anorexia nervosabinge eating disorderbulimia nervosacognitive flexibilitycompulsivityeating disordersobesityoverweightset-shifting
Type
Review Articles
Information
Psychological Medicine , Volume 44 , Issue 16 , December 2014 , pp. 3365 - 3385
Copyright
Copyright © Cambridge University Press 2014 

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References

Abbate-Daga, G, Buzzichelli, S, Amianto, F, Rocca, G, Marzola, E, McClintock, SM, Fassino, S (2011). Cognitive flexibility in verbal and nonverbal domains and decision making in anorexia nervosa patients: a pilot study. BMC Psychiatry 11, 162.CrossRefGoogle ScholarPubMed
Alvarez-Moya, EM, Jimenez-Murcia, S, Moragas, L, Gomez-Pena, M, Aymami, MN, Ochoa, C, Sanchez-Diaz, I, Menchon, JM, Fernandez-Aranda, F (2009). Executive functioning among female pathological gambling and bulimia nervosa patients: preliminary findings. Journal of the International Neuropsychological Society 15, 302–306.CrossRefGoogle ScholarPubMed
Anderluh, MB, Tchanturia, K, Rabe-Hesketh, S, Treasure, J (2003). Childhood obsessive-compulsive personality traits in adult women with eating disorders: defining a broader eating disorder phenotype. American Journal of Psychiatry 160, 242–247.CrossRefGoogle ScholarPubMed
Andrés-Perpiña, S, Lozano-Serra, E, Puig, O, Lera-Miguel, S, Lázaro, L, Castro-Fornieles, J (2011). Clinical and biological correlates of adolescent anorexia nervosa with impaired cognitive profile. European Child and Adolescent Psychiatry 20, 541–549.CrossRefGoogle ScholarPubMed
APA (2013). Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition: (DSM-5™). American Psychiatric Association: Arlington, VA.Google Scholar
Ariza, M, Garolera, M, Jurado, MA, Garcia-Garcia, I, Hernan, I, Sánchez-Garre, C, Vernet-Vernet, M, Sender-Palacios, MJ, Marques-Iturria, I, Pueyo, R, Segura, B, Narberhaus, A (2012). Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity. PLoS One 7, e41482.Google ScholarPubMed
Bardone-Cone, AM, Wonderlich, SA, Frost, RO, Bulik, CM, Mitchell, JE, Uppala, S, Simonich, H (2007). Perfectionism and eating disorders: current status and future directions. Clinical Psychology Review 27, 384–405.CrossRefGoogle ScholarPubMed
Baumgartner, RN, Heymsfield, SB, Roche, AF (1995). Human body composition and the epidemiology of chronic disease. Obesity Research 3, 73–95.CrossRefGoogle ScholarPubMed
Bienvenu, OJ, Samuels, JF, Riddle, MA, Hoehn-Saric, R, Liang, KY, Cullen, BA, Grados, MA, Nestadt, G (2000). The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study. Biological Psychiatry 48, 287–293.Google ScholarPubMed
Bischoff-Grethe, A, McCurdy, D, Grenesko-Stevens, E, Irvine, LE, Wagner, A, Yau, WY, Fennema-Notestine, C, Wierenga, CE, Fudge, JL, Delgado, MR, Kaye, WH (2013). Altered brain response to reward and punishment in adolescents with anorexia nervosa. Psychiatry Research 214, 331–340.CrossRefGoogle ScholarPubMed
Brand, M, Franke-Sievert, C, Jacoby, GE, Markowitsch, HJ, Tuschen-Caffier, B (2007). Neuropsychological correlates of decision making in patients with bulimia nervosa. Neuropsychology 21, 742–750.CrossRefGoogle ScholarPubMed
Brockmeyer, T, Ingenerf, K, Walther, S, Wild, B, Hartmann, M, Herzog, W, Bents, H, Friederich, H-C (2014). Training cognitive flexibility in patients with anorexia nervosa: a pilot randomized controlled trial of cognitive remediation therapy. International Journal of Eating Disorders 47, 24–31.CrossRefGoogle ScholarPubMed
Buhren, K, Mainz, V, Herpertz-Dahlmann, B, Schafer, K, Kahraman-Lanzerath, B, Lente, C, Konrad, K (2012). Cognitive flexibility in juvenile anorexia nervosa patients before and after weight recovery. Journal of Neural Transmission 119, 1047–1057.CrossRefGoogle ScholarPubMed
Bulik, CM, Sullivan, PF, Kendler, KS (2003). Genetic and environmental contributions to obesity and binge eating. International Journal of Eating Disorders 33, 293–298.CrossRefGoogle ScholarPubMed
Burgess, P, Shallice, T (1997). The Hayling and Brixton Tests. Thames Valley Test Company: Bury St Edmunds.Google Scholar
Cassin, SE, von Ranson, KM (2005). Personality and eating disorders: a decade in review. Clinical Psychology Review 25, 895–916.CrossRefGoogle ScholarPubMed
Castellini, G, Lo Sauro, C, Mannucci, E, Ravaldi, C, Rotella, CM, Faravelli, C, Ricca, V (2011). Diagnostic crossover and outcome predictors in eating disorders according to DSM-IV and DSM-V proposed criteria: a 6-year follow-up study. Psychosomatic Medicine 73, 270–279.CrossRefGoogle ScholarPubMed
Castro-Fornieles, J, Bargallo, N, Lazaro, L, Andres, S, Falcon, C, Plana, MT, Junque, C (2007). Adolescent anorexia nervosa: cross-sectional and follow-up frontal gray matter disturbances detected with proton magnetic resonance spectroscopy. Journal of Psychiatric Research 41, 952–958.CrossRefGoogle ScholarPubMed
Cavedini, P, Bassi, T, Ubbiali, A, Casolari, A, Giordani, S, Zorzi, C, Bellodi, L (2004). Neuropsychological investigation of decision-making in anorexia nervosa. Psychiatry Research 127, 259–266.CrossRefGoogle ScholarPubMed
Cavedini, P, Zorzi, C, Bassi, T, Gorini, A, Baraldi, C, Ubbiali, A, Bellodi, L (2006). Decision-making functioning as a predictor of treatment outcome in anorexia nervosa. Psychiatry Research 145, 179–187.CrossRefGoogle ScholarPubMed
Chamberlain, SR, Fineberg, NA, Blackwell, AD, Robbins, TW, Sahakian, BJ (2006). Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. American Journal of Psychiatry 163, 1282–1284.Google ScholarPubMed
Chamberlain, SR, Fineberg, NA, Menzies, LA, Blackwell, AD, Bullmore, ET, Robbins, TW, Sahakian, BJ (2007). Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. American Journal of Psychiatry 164, 335–338.CrossRefGoogle ScholarPubMed
Cohen, JI, Yates, KF, Duong, M, Convit, A (2011). Obesity, orbitofrontal structure and function are associated with food choice: a cross-sectional study. BMJ Open 1, e000175.CrossRefGoogle ScholarPubMed
Crowe, SF (1998). The differential contribution of mental tracking, cognitive flexibility, visual search, and motor speed to performance on parts A and B of the Trail Making Test. Journal of Clinical Psychology 54, 585–591.3.0.CO;2-K>CrossRefGoogle Scholar
Cserjési, R, Luminet, O, Poncelet, AS, Lenard, L (2009). Altered executive function in obesity. Exploration of the role of affective states on cognitive abilities. Appetite 52, 535–539.CrossRefGoogle ScholarPubMed
Cserjési, R, Molnar, D, Luminet, O, Lenard, L (2007). Is there any relationship between obesity and mental flexibility in children? Appetite 49, 675–678.CrossRefGoogle ScholarPubMed
Dalley, JW, Everitt, BJ, Robbins, TW (2011). Impulsivity, compulsivity, and top-down cognitive control. Neuron 69, 680–694.Google ScholarPubMed
Danner, UN, Sanders, N, Smeets, PA, van Meer, F, Adan, RA, Hoek, HW, van Elburg, AA (2012). Neuropsychological weaknesses in anorexia nervosa: set-shifting, central coherence, and decision making in currently ill and recovered women. International Journal of Eating Disorders 45, 685–694.CrossRefGoogle ScholarPubMed
Darcy, AM, Fitzpatrick, KK, Colborn, D, Manasse, S, Datta, N, Aspen, V, Shields, CS, Le Grange, D, Lock, J (2012). Set-shifting among adolescents with bulimic spectrum eating disorders. Psychosomatic Medicine 74, 869–872.CrossRefGoogle ScholarPubMed
Delis, D, Kaplan, E, Kramer, J (2001). Delis–Kaplan Executive Functioning System (D-KEFS): Examiner's Manual . The Psychological Corporation: San Antonio, TX.Google Scholar
Dmitrzak-Weglarz, M, Skibinska, M, Slopien, A, Tyszkiewicz, M, Pawlak, J, Maciukiewicz, M, Zaremba, D, Rajewski, A, Hauser, J (2013). Serum neurotrophin concentrations in Polish adolescent girls with anorexia nervosa. Neuropsychobiology 67, 25–32.CrossRefGoogle ScholarPubMed
Duchesne, M, Mattos, P, Appolinario, JC, de Freitas, SR, Coutinho, G, Santos, C, Coutinho, W (2010). Assessment of executive functions in obese individuals with binge eating disorder. Revista Brasileira de Psiquiatrica 32, 381–388.Google ScholarPubMed
Eddy, KT, Dorer, DJ, Franko, DL, Tahilani, K, Thompson-Brenner, H, Herzog, DB (2008). Diagnostic crossover in anorexia nervosa and bulimia nervosa: implications for DSM-V. American Journal of Psychiatry 165, 245–250.CrossRefGoogle ScholarPubMed
Fagundo, AB, de la Torre, R, Jimenez-Murcia, S, Aguera, Z, Granero, R, Tarrega, S, Botella, C, Banos, R, Fernandez-Real, JM, Rodriguez, R, Forcano, L, Fruhbeck, G, Gomez-Ambrosi, J, Tinahones, FJ, Fernandez-Garcia, JC, Casanueva, FF, Fernandez-Aranda, F (2012). Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity. PLoS One 7, e43382.CrossRefGoogle ScholarPubMed
Fairburn, CG, Cooper, Z, Shafran, R (2003). Cognitive behaviour therapy for eating disorders: a ‘transdiagnostic’ theory and treatment. Behaviour Research and Therapy 41, 509–528.CrossRefGoogle ScholarPubMed
Fassino, S, Piero, A, Daga, GA, Leombruni, P, Mortara, P, Rovera, GG (2002). Attentional biases and frontal functioning in anorexia nervosa. International Journal of Eating Disorders 31, 274–283.CrossRefGoogle ScholarPubMed
Fergenbaum, JH, Bruce, S, Lou, W, Hanley, AJ, Greenwood, C, Young, TK (2009). Obesity and lowered cognitive performance in a Canadian First Nations population. Obesity 17, 1957–1963.CrossRefGoogle Scholar
Fitzpatrick, S, Gilbert, S, Serpell, L (2013). Systematic review: are overweight and obese individuals impaired on behavioural tasks of executive functioning? Neuropsychology Review 23, 138–156.CrossRefGoogle ScholarPubMed
Fowler, L, Blackwell, A, Jaffa, A, Palmer, R, Robbins, TW, Sahakian, BJ, Dowson, JH (2006). Profile of neurocognitive impairments associated with female in-patients with anorexia nervosa. Psychological Medicine 36, 517–527.CrossRefGoogle ScholarPubMed
Freedman, M (1990). Object alternation and orbitofrontal system dysfunction in Alzheimer's and Parkinson's disease. Brain and Cognition 14, 134–143.CrossRefGoogle ScholarPubMed
Friederich, HC, Herzog, W (2011). Cognitive-behavioral flexibility in anorexia nervosa. Current Topics in Behavioral Neurosciences 6, 111–123.CrossRefGoogle ScholarPubMed
Friederich, HC, Walther, S, Bendszus, M, Biller, A, Thomann, P, Zeigermann, S, Katus, T, Brunner, R, Zastrow, A, Herzog, W (2012). Grey matter abnormalities within cortico-limbic-striatal circuits in acute and weight-restored anorexia nervosa patients. NeuroImage 59, 1106–1113.CrossRefGoogle ScholarPubMed
Galderisi, S, Bucci, P, Mucci, A, Bellodi, L, Cassano, GB, Santonastaso, P, Erzegovesi, S, Favaro, A, Mauri, M, Monteleone, P, Maj, M (2011). Neurocognitive functioning in bulimia nervosa: the role of neuroendocrine, personality and clinical aspects. Psychological Medicine 41, 839–848.CrossRefGoogle ScholarPubMed
Galimberti, E, Fadda, E, Cavallini, MC, Martoni, RM, Erzegovesi, S, Bellodi, L (2013). Executive functioning in anorexia nervosa patients and their unaffected relatives. Psychiatry Research 208, 238–244.CrossRefGoogle ScholarPubMed
Galimberti, E, Martoni, RM, Cavallini, MC, Erzegovesi, S, Bellodi, L (2012). Motor inhibition and cognitive flexibility in eating disorder subtypes. Progress in Neuro-Psychopharmacology and Biological Psychiatry 36, 307–312.CrossRefGoogle ScholarPubMed
Garcia-Garcia, I, Jurado, MA, Garolera, M, Segura, B, Sala-Llonch, R, Marques-Iturria, I, Pueyo, R, Sender-Palacios, MJ, Vernet-Vernet, M, Narberhaus, A, Ariza, M, Junque, C (2013). Alterations of the salience network in obesity: a resting-state fMRI study. Human Brain Mapping 34, 2786–2797.CrossRefGoogle ScholarPubMed
Giel, KE, Friederich, HC, Teufel, M, Hautzinger, M, Enck, P, Zipfel, S (2011). Attentional processing of food pictures in individuals with anorexia nervosa – an eye-tracking study. Biological Psychiatry 69, 661–667.CrossRefGoogle ScholarPubMed
Giel, KE, Wittorf, A, Wolkenstein, L, Klingberg, S, Drimmer, E, Schonenberg, M, Rapp, AM, Fallgatter, AJ, Hautzinger, M, Zipfel, S (2012). Is impaired set-shifting a feature of ‘pure’ anorexia nervosa? Investigating the role of depression in set-shifting ability in anorexia nervosa and unipolar depression. Psychiatry Research 200, 538–543.CrossRefGoogle ScholarPubMed
Gillberg, IC, Rastam, M, Wentz, E, Gillberg, C (2007). Cognitive and executive functions in anorexia nervosa ten years after onset of eating disorder. Journal of Clinical and Experimental Neuropsychology 29, 170–178.CrossRefGoogle ScholarPubMed
Goldschmidt, AB, Aspen, VP, Sinton, MM, Tanofsky-Kraff, M, Wilfley, DE (2008). Disordered eating attitudes and behaviors in overweight youth. Obesity 16, 257–264.CrossRefGoogle ScholarPubMed
Gonzales, MM, Tarumi, T, Miles, SC, Tanaka, H, Shah, F, Haley, AP (2010). Insulin sensitivity as a mediator of the relationship between BMI and working memory-related brain activation. Obesity (Silver Spring) 18, 2131–2137.CrossRefGoogle ScholarPubMed
Gunstad, J, Paul, RH, Cohen, RA, Tate, DF, Spitznagel, MB, Gordon, E (2007). Elevated body mass index is associated with executive dysfunction in otherwise healthy adults. Comprehensive Psychiatry 48, 57–61.CrossRefGoogle ScholarPubMed
Haines, J, Kleinman, KP, Rifas-Shiman, SL, Field, AE, Austin, SB (2010). Examination of shared risk and protective factors for overweight and disordered eating among adolescents. Archives of Pediatrics and Adolescent Medicine 164, 336–343.CrossRefGoogle ScholarPubMed
Halstead, W (1947). Brain and Intelligence: A Quantitative Study of the Frontal Lobes. University of Chicago Press: Chicago, IL.Google Scholar
Hatch, A, Madden, S, Kohn, MR, Clarke, S, Touyz, S, Gordon, E, Williams, LM (2010). In first presentation adolescent anorexia nervosa, do cognitive markers of underweight status change with weight gain following a refeeding intervention? International Journal of Eating Disorders 43, 295–306.CrossRefGoogle ScholarPubMed
Heaton, RK, Chelune, GJ, Talley, JL, Kay, GG, Curtiss, G (1993). Wisconsin Card Sorting Test Manual: Revised and Expanded. Psychological Assessment Resources: Odessa, FL.Google Scholar
Higgins, JP, Thompson, SG, Deeks, JJ, Altman, DG (2003). Measuring inconsistency in meta-analyses. British Medical Journal 327, 557–560.CrossRefGoogle ScholarPubMed
Hill, AJ (2007). Obesity and eating disorders. Obesity Reviews 8 (Suppl. 1), 151–155.CrossRefGoogle ScholarPubMed
Holliday, J, Tchanturia, K, Landau, S, Collier, D, Treasure, J (2005). Is impaired set-shifting an endophenotype of anorexia nervosa? American Journal of Psychiatry 162, 2269–2275.Google ScholarPubMed
Jones, BP, Duncan, CC, Brouwers, P, Mirsky, AF (1991). Cognition in eating disorders. Journal of Clinical and Experimental Neuropsychology 13, 711–728.CrossRefGoogle ScholarPubMed
Kaye, WH, Bulik, CM, Thornton, L, Barbarich, N, Masters, K (2004). Comorbidity of anxiety disorders with anorexia and bulimia nervosa. American Journal of Psychiatry 161, 2215–2221.CrossRefGoogle ScholarPubMed
Kim, YR, Kim, JE, Kim, MH (2010). Impaired set-shifting ability in patients with eating disorders, which is not moderated by their catechol-O-methyltransferase Val158Met genotype. Psychiatry Investigation 7, 298–301.Google Scholar
Kingston, K, Szmukler, G, Andrewes, D, Tress, B, Desmond, P (1996). Neuropsychological and structural brain changes in anorexia nervosa before and after refeeding. Psychological Medicine 26, 15–28.CrossRefGoogle ScholarPubMed
Konstantakopoulos, G, Tchanturia, K, Surguladze, SA, David, AS (2011). Insight in eating disorders: clinical and cognitive correlates. Psychological Medicine 41, 1951–1961.CrossRefGoogle ScholarPubMed
Lilenfeld, LR, Kaye, WH, Greeno, CG, Merikangas, KR, Plotnicov, K, Pollice, C, Rao, R, Strober, M, Bulik, CM, Nagy, L (1998). A controlled family study of anorexia nervosa and bulimia nervosa: psychiatric disorders in first-degree relatives and effects of proband comorbidity. Archives of General Psychiatry 55, 603–610.CrossRefGoogle ScholarPubMed
Lilenfeld, LR, Stein, D, Bulik, CM, Strober, M, Plotnicov, K, Pollice, C, Rao, R, Merikangas, KR, Nagy, L, Kaye, WH (2000). Personality traits among currently eating disordered, recovered and never ill first-degree female relatives of bulimic and control women. Psychological Medicine 30, 1399–1410.CrossRefGoogle ScholarPubMed
Lock, J, Agras, WS, Fitzpatrick, KK, Bryson, SW, Jo, B, Tchanturia, K (2013). Is outpatient cognitive remediation therapy feasible to use in randomized clinical trials for anorexia nervosa? International Journal of Eating Disorders 46, 567–575.CrossRefGoogle ScholarPubMed
Lounes, N, Khan, G, Tchanturia, K (2011). Assessment of cognitive flexibility in anorexia nervosa – self-report or experimental measure? A brief report. Journal of the International Neuropsychological Society 17, 925–928.CrossRefGoogle ScholarPubMed
Maayan, L, Hoogendoorn, C, Sweat, V, Convit, A (2011). Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction. Obesity 19, 1382–1387.CrossRefGoogle ScholarPubMed
Mataix-Cols, D, Pertusa, A, Leckman, JF (2007). Issues for DSM-V: how should obsessive-compulsive and related disorders be classified? American Journal of Psychiatry 164, 1313–1314.CrossRefGoogle ScholarPubMed
Mathias, JL, Kent, PS (1998). Neuropsychological consequences of extreme weight loss and dietary restriction in patients with anorexia nervosa. Journal of Clinical and Experimental Neuropsychology 20, 548–564.CrossRefGoogle ScholarPubMed
McAnarney, ER, Zarcone, J, Singh, P, Michels, J, Welsh, S, Litteer, T, Wang, H, Klein, JD (2011). Restrictive anorexia nervosa and set-shifting in adolescents: a biobehavioral interface. Journal of Adolescent Health 49, 99–101.CrossRefGoogle ScholarPubMed
Meade, J, Nam, KB, Beckerman, AP, Hatchwell, BJ (2010). Consequences of ‘load-lightening’ for future indirect fitness gains by helpers in a cooperatively breeding bird. Journal of Animal Ecology 79, 529–537.Google Scholar
Miyake, A, Friedman, NP, Emerson, MJ, Witzki, AH, Howerter, A, Wager, TD (2000). The unity and diversity of executive functions and their contributions to complex ‘Frontal Lobe’ tasks: a latent variable analysis. Cognitive Psychology 41, 49–100.CrossRefGoogle ScholarPubMed
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG; PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Open Medicine 3, e123–e130.Google ScholarPubMed
Monteleone, P, Di Genio, M, Monteleone, AM, Di Filippo, C, Maj, M (2011). Investigation of factors associated to crossover from anorexia nervosa restricting type (ANR) and anorexia nervosa binge-purging type (ANBP) to bulimia nervosa and comparison of bulimia nervosa patients with or without previous ANR or ANBP. Comprehensive Psychiatry 52, 56–62.CrossRefGoogle ScholarPubMed
Mount, R, Neziroglu, F, Taylor, CJ (1990). An obsessive-compulsive view of obesity as its treatment. Journal of Clinical Psychology 46, 68–78.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Murphy, R, Nutzinger, DO, Paul, T, Leplow, B (2002). Dissociated conditional-associative learning in anorexia nervosa. Journal of Clinical and Experimental Neuropsychology 24, 176–186.CrossRefGoogle ScholarPubMed
Murphy, R, Nutzinger, DO, Paul, T, Leplow, B (2004). Conditional-associative learning in eating disorders: a comparison with OCD. Journal of Clinical and Experimental Neuropsychology 26, 190–199.CrossRefGoogle ScholarPubMed
Nakazato, M, Hashimoto, K, Schmidt, U, Tchanturia, K, Campbell, IC, Collier, DA, Iyo, M, Treasure, J (2010). Serum glutamine, set-shifting ability and anorexia nervosa. Annals of General Psychiatry 9, 29.CrossRefGoogle ScholarPubMed
Nakazato, M, Tchanturia, K, Schmidt, U, Campbell, IC, Treasure, J, Collier, DA, Hashimoto, K, Iyo, M (2009). Brain-derived neurotrophic factor (BDNF) and set-shifting in currently ill and recovered anorexia nervosa (AN) patients. Psychological Medicine 39, 1029–1035.CrossRefGoogle ScholarPubMed
Nikendei, C, Funiok, C, Pfuller, U, Zastrow, A, Aschenbrenner, S, Weisbrod, M, Herzog, W, Friederich, HC (2011). Memory performance in acute and weight-restored anorexia nervosa patients. Psychological Medicine 41, 829–838.Google ScholarPubMed
Ohrmann, P, Kersting, A, Suslow, T, Lalee-Mentzel, J, Donges, US, Fiebich, M, Arolt, V, Heindel, W, Pfleiderer, B (2004). Proton magnetic resonance spectroscopy in anorexia nervosa: correlations with cognition. Neuroreport 15, 549–553.CrossRefGoogle ScholarPubMed
Pavan, C, Azzi, M, Lancerotto, L, Marini, M, Busetto, L, Bassetto, F, Vindigni, V (2013). Overweight/obese patients referring to plastic surgery: temperament and personality traits. Obesity Surgery 23, 437–445.CrossRefGoogle ScholarPubMed
Pennington, BF, Ozonoff, S (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry 37, 51–87.CrossRefGoogle ScholarPubMed
Petry, NM, Barry, D, Pietrzak, RH, Wagner, JA (2008). Overweight and obesity are associated with psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychosomatic Medicine 70, 288–297.CrossRefGoogle ScholarPubMed
Phillips, KA, Stein, DJ, Rauch, SL, Hollander, E, Fallon, BA, Barsky, A, Fineberg, N, Mataix-Cols, D, Ferrao, YA, Saxena, S, Wilhelm, S, Kelly, MM, Clark, LA, Pinto, A, Bienvenu, OJ, Farrow, J, Leckman, J (2010). Should an obsessive-compulsive spectrum grouping of disorders be included in DSM-V? Depression and Anxiety 27, 528–555.CrossRefGoogle ScholarPubMed
Pignatti, R, Bernasconi, V (2013). Personality, clinical features, and test instructions can affect executive functions in eating disorders. Eating Behaviors 14, 233–236.CrossRefGoogle ScholarPubMed
Pi-Sunyer, FX (2002). The medical risks of obesity. Obesity Surgery 12 (Suppl. 1), 6S–11S.CrossRefGoogle ScholarPubMed
Reitan, RM, Wolfson, D (1985). The Halstead-Reitan Neuropsychological Test Battery: Therapy and Clinical Interpretation. Neuropsychological Press: Tucson, AZ.Google Scholar
Ridderinkhof, KR, Span, MM, van der Molen, MW (2002). Perseverative behavior and adaptive control in older adults: performance monitoring, rule induction, and set shifting. Brain Cognition 49, 382–401.CrossRefGoogle ScholarPubMed
Robbins, TW, Gillan, CM, Smith, DG, de Wit, S, Ersche, KD (2012). Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends in Cognitive Sciences 16, 81–91.CrossRefGoogle ScholarPubMed
Robbins, TW, James, M, Owen, AM, Sahakian, BJ, Lawrence, AD, McInnes, L, Rabbitt, PM (1998). A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Battery. Journal of the International Neuropsychological Society 4, 474–490.Google Scholar
Roberts, ME, Tchanturia, K, Stahl, D, Southgate, L, Treasure, J (2007). A systematic review and meta-analysis of set-shifting ability in eating disorders. Psychological Medicine 37, 1075–1084.CrossRefGoogle ScholarPubMed
Roberts, ME, Tchanturia, K, Treasure, JL (2010). Exploring the neurocognitive signature of poor set-shifting in anorexia and bulimia nervosa. Journal of Psychiatry Research 44, 964–970.CrossRefGoogle ScholarPubMed
Sarrar, L, Ehrlich, S, Merle, JV, Pfeiffer, E, Lehmkuhl, U, Schneider, N (2011). Cognitive flexibility and Agouti-related protein in adolescent patients with anorexia nervosa. Psychoneuroendocrinology 36, 1396–1406.CrossRefGoogle ScholarPubMed
Sato, Y, Saito, N, Utsumi, A, Aizawa, E, Shoji, T, Izumiyama, M, Mushiake, H, Hongo, M, Fukudo, S (2013). Neural basis of impaired cognitive flexibility in patients with anorexia nervosa. PLoS One 8, e61108.CrossRefGoogle ScholarPubMed
Schmidt, U, Treasure, J (2006). Anorexia nervosa: valued and visible. A cognitive-interpersonal maintenance model and its implications for research and practice. British Journal of Clinical Psychology 45, 343–366.CrossRefGoogle ScholarPubMed
Shott, ME, Filoteo, JV, Bhatnagar, KA, Peak, NJ, Hagman, JO, Rockwell, R, Kaye, WH, Frank, GK (2012). Cognitive set-shifting in anorexia nervosa. European Eating Disorders Review 20, 343–349.CrossRefGoogle ScholarPubMed
Stedal, K, Frampton, I, Landro, NI, Lask, B (2012). An examination of the ravello profile – a neuropsychological test battery for anorexia nervosa. European Eating Disorders Review 20, 175–181.CrossRefGoogle ScholarPubMed
Steinglass, JE, Walsh, BT, Stern, Y (2006). Set shifting deficit in anorexia nervosa. Journal of the International Neuropsychological Society 12, 431–435.CrossRefGoogle ScholarPubMed
Sterne, JA, Sutton, AJ, Ioannidis, JP, Terrin, N, Jones, DR, Lau, J, Carpenter, J, Rucker, G, Harbord, RM, Schmid, CH, Tetzlaff, J, Deeks, JJ, Peters, J, Macaskill, P, Schwarzer, G, Duval, S, Altman, DG, Moher, D, Higgins, JP (2011). Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. British Medical Journal 343, d4002.CrossRefGoogle ScholarPubMed
Svaldi, J, Brand, M, Tuschen-Caffier, B (2010). Decision-making impairments in women with binge eating disorder. Appetite 54, 84–92.CrossRefGoogle ScholarPubMed
Szmukler, GI, Andrewes, D, Kingston, K, Chen, L, Stargatt, R, Stanley, R (1992). Neuropsychological impairment in anorexia nervosa: before and after refeeding. Journal of Clinical and Experimental Neuropsychology 14, 347–352.CrossRefGoogle ScholarPubMed
Tchanturia, K, Anderluh, MB, Morris, RG, Rabe-Hesketh, S, Collier, DA, Sanchez, P, Treasure, JL (2004 a). Cognitive flexibility in anorexia nervosa and bulimia nervosa. Journal of the International Neuropsychological Society 10, 513–520.Google ScholarPubMed
Tchanturia, K, Davies, H, Lopez, C, Schmidt, U, Treasure, J, Wykes, T (2008). Research Letter. Neuropsychological task performance before and after cognitive remediation in anorexia nervosa: a pilot case-series. Psychological Medicine 38, 1371–1373.CrossRefGoogle ScholarPubMed
Tchanturia, K, Davies, H, Roberts, M, Harrison, A, Nakazato, M, Schmidt, U, Treasure, J, Morris, R (2012). Poor cognitive flexibility in eating disorders: examining the evidence using the Wisconsin Card Sorting Task. PLoS One 7, e28331.CrossRefGoogle ScholarPubMed
Tchanturia, K, Harrison, A, Davies, H, Roberts, M, Oldershaw, A, Nakazato, M, Stahl, D, Morris, R, Schmidt, U, Treasure, J (2011). Cognitive flexibility and clinical severity in eating disorders. PLoS One 6, e20462.CrossRefGoogle ScholarPubMed
Tchanturia, K, Morris, RG, Anderluh, MB, Collier, DA, Nikolaou, V, Treasure, J (2004 b). Set shifting in anorexia nervosa: an examination before and after weight gain, in full recovery and relationship to childhood and adult OCPD traits. Journal of Psychiatric Research 38, 545–552.Google ScholarPubMed
Tchanturia, K, Serpell, L, Troop, N, Treasure, J (2001). Perceptual illusions in eating disorders: rigid and fluctuating styles. Journal of Behavior Therapy and Experimental Psychiatry 32, 107–115.CrossRefGoogle ScholarPubMed
Tenconi, E, Santonastaso, P, Degortes, D, Bosello, R, Titton, F, Mapelli, D, Favaro, A (2010). Set-shifting abilities, central coherence, and handedness in anorexia nervosa patients, their unaffected siblings and healthy controls: exploring putative endophenotypes. World Journal of Biological Psychiatry 11, 813–823.CrossRefGoogle ScholarPubMed
Thompson, SBN (1993). Implications of neuropsychological test results of women in a new phase of anorexia nervosa. European Eating Disorders Review 1, 152–165.CrossRefGoogle Scholar
Tokley, M, Kemps, E (2007). Preoccupation with detail contributes to poor abstraction in women with anorexia nervosa. Journal of Clinical and Experimental Neuropsychology 29, 734–741.CrossRefGoogle ScholarPubMed
Touyz, SW, Beumont, PJV, Johnstone, LC (1986). Neuropsychological correlates of dieting disorders. International Journal of Eating Disorders 5, 1025–1034.Google Scholar
Treasure, J, Claudino, AM, Zucker, N (2010). Eating disorders. Lancet 375, 583–593.CrossRefGoogle ScholarPubMed
Uznadze, DN (1966). The Psychology of Set. Consultants’ Bureau: New York.Google Scholar
Van den Eynde, F, Guillaume, S, Broadbent, H, Stahl, D, Campbell, IC, Schmidt, U, Tchanturia, K (2011). Neurocognition in bulimic eating disorders: a systematic review. Acta Psychiatrica Scandinavica 124, 120–140.CrossRefGoogle ScholarPubMed
Van den Eynde, F, Treasure, J (2009). Neuroimaging in eating disorders and obesity: implications for research. Child and Adolescent Psychiatric Clinics of North America 18, 95–115.CrossRefGoogle ScholarPubMed
Verdejo-Garcia, A, Perez-Exposito, M, Schmidt-Rio-Valle, J, Fernandez-Serrano, MJ, Cruz, F, Perez-Garcia, M, Lopez-Belmonte, G, Martin-Matillas, M, Martin-Lagos, JA, Marcos, A, Campoy, C (2010). Selective alterations within executive functions in adolescents with excess weight. Obesity 18, 1572–1578.CrossRefGoogle ScholarPubMed
Villarejo, C, Fernandez-Aranda, F, Jimenez-Murcia, S, Penas-Lledo, E, Granero, R, Penelo, E, Tinahones, FJ, Sancho, C, Vilarrasa, N, Montserrat-Gil de Bernabe, M, Casanueva, FF, Fernandez-Real, JM, Fruhbeck, G, De la Torre, R, Treasure, J, Botella, C, Menchon, JM (2012). Lifetime obesity in patients with eating disorders: increasing prevalence, clinical and personality correlates. European Eating Disorders Review 20, 250–254.CrossRefGoogle ScholarPubMed
Volkow, ND, Wang, GJ, Fowler, JS, Tomasi, D, Baler, R (2012). Food and drug reward: overlapping circuits in human obesity and addiction. Current Topics in Behavioral Neurosciences 11, 1–24.Google ScholarPubMed
Volkow, ND, Wang, GJ, Fowler, JS, Tomasi, D, Telang, F (2011). Addiction: beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences USA 108, 15037–15042.CrossRefGoogle ScholarPubMed
Weigl, E (1941). On the psychology of so-called processes of abstraction. Journal of Abnormal and Social Psychology 36, 3–33.CrossRefGoogle Scholar
WHO (2000). Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization Technical Report Series 894, i–xii, 1–253.Google Scholar
Williamson, DA, Womble, LG, Smeets, MA, Netemeyer, RG, Thaw, JM, Kutlesic, V, Gleaves, DH (2002). Latent structure of eating disorder symptoms: a factor analytic and taxometric investigation. American Journal of Psychiatry 159, 412–418.CrossRefGoogle ScholarPubMed
Witt, ED, Ryan, C, Hsu, LK (1985). Learning deficits in adolescents with anorexia nervosa. Journal of Nervous and Mental Disease 173, 182–184.CrossRefGoogle ScholarPubMed
Wittorf, A, Giel, KE, Hautzinger, M, Rapp, A, Schonenberg, M, Wolkenstein, L, Zipfel, S, Mehl, S, Fallgatter, AJ, Klingberg, S (2012). Specificity of jumping to conclusions and attributional biases: a comparison between patients with schizophrenia, depression, and anorexia nervosa. Cognitive Neuropsychiatry 17, 262–286.CrossRefGoogle ScholarPubMed
Zakzanis, KK, Campbell, Z, Polsinelli, A (2010). Quantitative evidence for distinct cognitive impairment in anorexia nervosa and bulimia nervosa. Journal of Neuropsychology 4, 89–106.CrossRefGoogle ScholarPubMed
Zastrow, A, Kaiser, S, Stippich, C, Walther, S, Herzog, W, Tchanturia, K, Belger, A, Weisbrod, M, Treasure, J, Friederich, HC (2009). Neural correlates of impaired cognitive-behavioral flexibility in anorexia nervosa. American Journal of Psychiatry 166, 608–616.CrossRefGoogle ScholarPubMed
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