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Schizophrenia: complex genetics, not fairy tales

A commentary on ‘The emperors of the schizophrenia polygene have no clothes’ by Crow (2008)

Published online by Cambridge University Press:  26 June 2008

M. C. O'Donovan ,
N. Craddock  and
M. J. Owen
M. C. O'Donovan
Affiliation:
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
N. Craddock*
Affiliation:
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
M. J. Owen
Affiliation:
Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
*
*Address for correspondence: Dr N. Craddock, Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. (Email: [email protected])
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Abstract

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Keywords

Association studygeneticsphenotypepsychosisschizophrenia
Type
Commentary
Information
Psychological Medicine , Volume 38 , Issue 12 , December 2008 , pp. 1697 - 1699
Copyright
Copyright © 2008 Cambridge University Press

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References

Angst, J (2007). Psychiatric diagnoses: the weak component of modern research. World Psychiatry 6, 94–95.Google ScholarPubMed
Bray, NJ, Preece, A, Williams, NM, Moskvina, V, Buckland, P, Owen, MJ, O'Donovan, MC (2005). Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1expression. Human Molecular Genetics 14, 1947–1954.CrossRefGoogle Scholar
Craddock, N, O'Donovan, MC, Owen, MJ (2006). Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia Bulletin 32, 9–16.CrossRefGoogle ScholarPubMed
Craddock, N, O'Donovan, MC, Owen, MJ (2007). Phenotypic and genetic complexity of psychosis. British Journal of Psychiatry 190, 200–203 [Erratum in British Journal of Psychiatry (2007), 190, 365].CrossRefGoogle ScholarPubMed
Craddock, N, Owen, MJ (2005). The beginning of the end for the Kraepelinian dichotomy. British Journal of Psychiatry 186, 364–366.CrossRefGoogle ScholarPubMed
Craddock, N, Owen, MJ (2007). Rethinking psychosis: the disadvantages of a dichotomous classification now outweigh the advantages. World Psychiatry 6, 84–91.Google ScholarPubMed
Crow, TJ (1987). Continuum of psychosis and the gene. British Journal of Psychiatry 151, 125–126.CrossRefGoogle ScholarPubMed
Crow, TJ (1995). A continuum of psychosis, one human gene, and not much else – the case for homogeneity. Schizophrenia Research 17, 135–145.CrossRefGoogle Scholar
Crow, TJ (2008). The emperors of the schizophrenia polygene have no clothes. Psychological Medicine. Published online: 21 April 2008. doi: 10.1017/S0033291708003395.CrossRefGoogle Scholar
Hall, J, Whalley, HC, Job, DE, Baig, BJ, McIntosh, AM, Evans, KL, Thomson, PA, Porteous, DJ, Cunningham-Owens, DG, Johnstone, EC, Lawrie, SM (2006). A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nature Neuroscience 9, 1477–1478.CrossRefGoogle ScholarPubMed
Ishizuka, K, Paek, M, Kamiya, A, Sawa, A (2006). A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition and mental conditions. Biological Psychiatry 59, 1189–1197.CrossRefGoogle ScholarPubMed
Kirov, G, Gumus, D, Chen, W, Norton, N, Georgieva, L, Sari, M, O'Donovan, MC, Erdogan, F, Owen, MJ, Ropers, HH, Ullmann, R (2008). Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Human Molecular Genetics 17, 458–465.CrossRefGoogle ScholarPubMed
Law, AJ, Lipska, BK, Weickert, CS, Hyde, TM, Straub, RE, Hashimoto, R, Harrison, PJ, Kleinman, JE, Weinberger, DR (2006). Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proceedings of the National Academy of Sciences USA 103, 6747–6752.CrossRefGoogle ScholarPubMed
McCarthy, MI, Abecasis, GR, Cardon, LR, Goldstein, DB, Little, J, Ioannidis, JP, Hirschhorn, JN (2008). Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nature Review Genetics 9, 356–369.CrossRefGoogle ScholarPubMed
Murray, RM, Sham, P, Van Os, J, Zanelli, J, Cannon, M, McDonald, C (2004). A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophrenia Research 71, 405–416.CrossRefGoogle ScholarPubMed
Owen, MJ, Craddock, N, Jablensky, A (2007). The genetic deconstruction of psychosis. Schizophrenia Bulletin 33, 905–911.CrossRefGoogle ScholarPubMed
Owen, MJ, Craddock, N, O'Donovan, MC (2005). Schizophrenia: genes at last? Trends in Genetics 21, 518–525.CrossRefGoogle ScholarPubMed
Petretto, E, Liu, ET, Aitman, TJ (2007). A gene harvest revealing the archeology and complexity of human disease. Nature Genetics 39, 1299–1301.CrossRefGoogle ScholarPubMed
Porteous, DJ, Thomson, P, Brandon, NJ, Millar, JK (2006). The genetics and biology of DISC1 – an emerging role in psychosis and cognition. Biological Psychiatry 60, 123–131.CrossRefGoogle ScholarPubMed
Risch, N (1990). Linkage strategies for genetically complex traits. I. Multilocus models. American Journal of Human Genetics 46, 222–228.Google ScholarPubMed
Walsh, T, McClellan, JM, McCarthy, SE, Addington, AM, Pierce, SB, Cooper, GM, Nord, AS, Kusenda, M, Malhotra, D, Bhandari, A, Stray, SM, Rippey, CF, Roccanova, P, Makarov, V, Lakshmi, B, Findling, RL, Sikich, L, Stromberg, T, Merriman, B, Gogtay, N, Butler, P, Eckstrand, K, Noory, L, Gochman, P, Long, R, Chen, Z, Davis, S, Baker, C, Eichler, EE, Meltzer, PS, Nelson, SF, Singleton, AB, Lee, MK, Rapoport, JL, King, MC, Sebat, J (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320, 539–543.CrossRefGoogle ScholarPubMed
Wellcome Trust Case Control Consortium (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661–678.CrossRefGoogle Scholar
Zeggini, E, Scott, LJ, Saxena, R, Voight, BF, Marchini, JL, Hu, T, de Bakker, PI, Abecasis, GR, Almgren, P, Andersen, G, Ardlie, K, Boström, KB, Bergman, RN, Bonnycastle, LL, Borch-Johnsen, K, Burtt, NP, Chen, H, Chines, PS, Daly, MJ, Deodhar, P, Ding, CJ, Doney, AS, Duren, WL, Elliott, KS, Erdos, MR, Frayling, TM, Freathy, RM, Gianniny, L, Grallert, H, Grarup, N, Groves, CJ, Guiducci, C, Hansen, T, Herder, C, Hitman, GA, Hughes, TE, Isomaa, B, Jackson, AU, Jørgensen, T, Kong, A, Kubalanza, K, Kuruvilla, FG, Kuusisto, J, Langenberg, C, Lango, H, Lauritzen, T, Li, Y, Lindgren, CM, Lyssenko, V, Marvelle, AF, Meisinger, C, Midthjell, K, Mohlke, KL, Morken, MA, Morris, AD, Narisu, N, Nilsson, P, Owen, KR, Palmer, CN, Payne, F, Perry, JR, Pettersen, E, Platou, C, Prokopenko, I, Qi, L, Qin, L, Rayner, NW, Rees, M, Roix, JJ, Sandbæk, A, Shields, B, Sjögren, M, Steinthorsdottir, V, Stringham, HM, Swift, AJ, Thorleifsson, G, Thorsteinsdottir, U, Timpson, NJ, Tuomi, T, Tuomilehto, J, Walker, M, Watanabe, RM, Weedon, MN, Willer, CJ, Wellcome Trust Case Control Consortium, Illig, T, Hveem, K, Hu, FB, Laakso, M, Stefansson, K, Pedersen, O, Wareham, NJ, Barroso, I, Hattersley, AT, Collins, FS, Groop, L, McCarthy, MI, Boehnke, M, Altshuler, D (2008). Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nature Genetics 40, 638–645.CrossRefGoogle ScholarPubMed