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The relationship between physical activity, BMI, circadian rhythm, and sleep with cognition in bipolar disorder

Published online by Cambridge University Press:  29 June 2020

Jennifer L. Burgess Open the ORCID record for Jennifer L. Burgess [Opens in a new window] ,
Andrew J. Bradley ,
Kirstie N. Anderson ,
P. Gallagher  and
R. Hamish McAllister-Williams
Jennifer L. Burgess*
Affiliation:
Academic Psychiatry Department, Campus of Ageing and Vitality, Westgate Road, Newcastle-upon-Tyne, NE4 6BE, UK
Andrew J. Bradley
Affiliation:
Academic Psychiatry Department, Campus of Ageing and Vitality, Westgate Road, Newcastle-upon-Tyne, NE4 6BE, UK
Kirstie N. Anderson
Affiliation:
Academic Psychiatry Department, Campus of Ageing and Vitality, Westgate Road, Newcastle-upon-Tyne, NE4 6BE, UK
P. Gallagher
Affiliation:
Academic Psychiatry Department, Campus of Ageing and Vitality, Westgate Road, Newcastle-upon-Tyne, NE4 6BE, UK
R. Hamish McAllister-Williams
Affiliation:
Academic Psychiatry Department, Campus of Ageing and Vitality, Westgate Road, Newcastle-upon-Tyne, NE4 6BE, UK
*
Author for correspondence: Jennifer L. Burgess, E-mail: [email protected]
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Abstract

Background

Cognitive deficits affect a significant proportion of patients with bipolar disorder (BD). Problems with sustained attention have been found independent of mood state and the causes are unclear. We aimed to investigate whether physical parameters such as activity levels, sleep, and body mass index (BMI) may be contributing factors.

Methods

Forty-six patients with BD and 42 controls completed a battery of neuropsychological tests and wore a triaxial accelerometer for 21 days which collected information on physical activity, sleep, and circadian rhythm. Ex-Gaussian analyses were used to characterise reaction time distributions. We used hierarchical regression analyses to examine whether physical activity, BMI, circadian rhythm, and sleep predicted variance in the performance of cognitive tasks.

Results

Neither physical activity, BMI, nor circadian rhythm predicted significant variance on any of the cognitive tasks. However, the presence of a sleep abnormality significantly predicted a higher intra-individual variability of the reaction time distributions on the Attention Network Task.

Conclusions

This study suggests that there is an association between sleep abnormalities and cognition in BD, with little or no relationship with physical activity, BMI, and circadian rhythm.

Keywords

Bipolar disorderBMIcircadian rhythmcognitionphysical activitysleep
Type
Original Article
Information
Psychological Medicine , Volume 52 , Issue 3 , February 2022 , pp. 467 - 475
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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