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Reduced plasma oestrogen stimulated neurophysin and delayed response to oestrogen challenge in Alzheimer's disease

Published online by Cambridge University Press:  09 July 2009

Janice Christie ,
Robert Hunter ,
John Bennie ,
Helen Wilson ,
Sheena Carroll  and
George Fink
Janice Christie
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh
Robert Hunter*
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh
John Bennie
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh
Helen Wilson
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh
Sheena Carroll
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh
George Fink
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh
*
1Address for correspondence: Dr Robert Hunter, MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH 10 5HF.
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Synopsis

Plasma concentrations of oestrogen stimulated neurophysin (ESN) were reduced in 28 patients with Alzheimer's disease (AD) compared with 14 age-matched controls, 16 patients with other presenile dementias and 12 patients with major depressive disorder. The ESN response to oestrogen challenge was delayed in 10 AD patients compared with 7 age-matched controls. Reduced basal and oestrogen stimulated plasma ESN may be related to impaired responsiveness of the hypothalamo-neurohypophysial neurons and/or a reduction in the amount of pituitary ESN available for release. Plasma ESN measurements may be of value for excluding the diagnosis of AD in patients with dementia who present before the age of 65.

Type
Orginal Articles
Information
Psychological Medicine , Volume 20 , Issue 4 , November 1990 , pp. 773 - 777
Copyright
Copyright © Cambridge University Press 1990

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References

REFERENCES

Amico, J. A., Seif, S. M. & Robinson, A. G. (1981). Oxytocin in human plasma: correlation with neurophysin and stimulation with estrogen. Journal of Clinical Endocrinology and Metabolism 52, 988–993.CrossRefGoogle ScholarPubMed
Blackburn, I. M. & Tyrer, G. M. B. (1985). The value of Luna's neuropsychological investigation for the assessment of cognitive dysfunction in Alzheimer-type dementia. British Journal of Clinical Psychology 24, 171–179.Google Scholar
Christie, J. E., Whalley, L. J., Bennie, J., Dick, H., Blackburn, I. M., Blackwood, D. H. R. & Fink, G. (1987). Characteristic plasma hormone changes in Alzheimer's disease. British Journal of Psychiatry 150, 674–681.Google Scholar
Fillilt, H. M., Ashby, D., Weinreg, H., Zabriskie, J. B., Luine, V. N. & McEwen, B. S. (1986) Estrogen levels in postmenopausal women with senile dementia-Alzheimer's type (SDAT) are significantly lower than matched controls. Society of Neuroscience Abstracts 12, 259.11.Google Scholar
Fliers, E., Swaab, D. F., Pool, Chr. W. & Verwer, R. W. H. (1985). The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia. Brain Research 342, 45–53.CrossRefGoogle ScholarPubMed
Hachinski, V. C., Iliff, L. D., Zihka, E., McAllister, V. L., Marshall, J., Russell, R. W. R. & Symon, L. (1975). Cerebral blood flow in dementia. Archives of Neurology 32, 632–637.Google Scholar
Hardy, J., Adolfsson, R., Alafuzoff, I., Bucht, G., Marcusson, J., Nyberg, P., Perdahl, E., Wester, P. & Winblad, B. (1985). Review, Transmitter deficits in Alzheimer's disease. Neurochemistry International 7, 545–563.Google Scholar
Hoogendijk, J. E., Fliers, E., Swaab, D. F. & Verwer, R. W. H. (1985). Activation of vasopressin neurons in the human supraoptic and paraventricular nucleus in senescence and senile dementia. Journal of the Neurological Sciences 69, 291–299.CrossRefGoogle ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. & Stadlan, D. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939–944.CrossRefGoogle ScholarPubMed
Norbiato, G., Bevilacqua, M., Carella, F., Chebat, E., Raggi, U., Bertora, P., Grassi, M. P. & Mangoni, A. (1988). Alterations in vasopressin regulation in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry 51, 903–908.Google Scholar
Pfaff, D. W., Gerlach, J. L., McEwan, B. S., Ferin, M., Carmel, P. & Zimmerman, E. A. (1976). Auloradiographic localization of hormone-concentrating cells in the brain of the female Rhesus monkey. Journal of Comparative Neurology 170, 279–294.CrossRefGoogle ScholarPubMed
Raskind, M. A., Peskind, E. R., Veith, R. C., Risse, S. C., Lampe, T. H., Borson, S., Gumbrecht, G. & Dorsa, D. M. (1989). Neuroendocrine responses to physostigmine in Alzheimer's disease. Archives of General Psychiatry 46, 535–540.Google Scholar
Reichlin, S. (1985). Neuroendocrinology. In William's Textbook of Endocrinology (ed. Wilson, J. D. and Foster, D. W.), pp. 492–567. W. B. Saunders: LondonGoogle Scholar
Robinson, A. G. (1975). Isolation, assay, and secretion of individual human neurophysins. Journal of Clinical Investigation 55, 360–367.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1978). Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry 36, 773–782.Google Scholar
Sunderland, T., Merril, C. R., Harrington, M. G., Lawlor, B. A., Molchan, S. E., Martinez, R. & Murphy, D. L. (1989). Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease. Lancet ii, 570.CrossRefGoogle Scholar
Whalley, L. J., Eagles, J. M., Bowler, G. M. R., Bennie, J. G., Dick, H. R., McGuire, R. J. & Fink, G. (1987) Selective effects of ECT on hypothalamic-pituitary activity. Psychological Medicine 17, 319–328.Google Scholar
Yates, C. M., Bennie, J., Wilson, H., Carroll, S., Hunter, R., Fink, G. & Gordon, A. (1990). Neuropeptides in post-mortem hypothalamus and pituitary in Alzheimer-type dementia. (Submitted.)Google Scholar