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Partitioning the etiology of hoarding and obsessive–compulsive symptoms

Published online by Cambridge University Press:  20 February 2014

C. A. Mathews ,
K. Delucchi ,
D. C. Cath ,
G. Willemsen  and
D. I. Boomsma
C. A. Mathews*
Affiliation:
Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
K. Delucchi
Affiliation:
Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
D. C. Cath
Affiliation:
Department of Clinical and Health Psychology, Utrecht University and Altrecht Academic Anxiety Disorders Center, Utrecht, the Netherlands
G. Willemsen
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, Amsterdam, the Netherlands
D. I. Boomsma
Affiliation:
Department of Biological Psychology, VU University, Amsterdam, Amsterdam, the Netherlands
*
*Address for correspondence: C. A. Mathews, M.D., Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143-0984, USA. (Email: [email protected])
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Abstract

Background

Until recently, hoarding was considered an obsessive–compulsive symptom (OCS). However, current evidence suggests that these two phenotypes may be clinically, and perhaps etiologically, distinct. Both hoarding and OCS have a genetic etiology, but the degree of unique and shared genetic contributions to these phenotypes has not been well studied.

Method

Prevalence rates were assessed for hoarding and OCS in a sample of adult twin pairs (n = 7906 twins) and their family members from the Netherlands Twin Register (total sample = 15 914). Using Mplus, genetic analyses using liability threshold models were conducted for both phenotypes, for their co-morbidity, and for specific hoarding symptoms (cluttering, discarding and acquiring).

Results

Of the total sample, 6.7% met criteria for clinically significant hoarding; endorsement of all three hoarding symptoms was ⩾79%. Men had slightly higher rates than women. Also, 5.7% met criteria for clinically significant OCS; rates were similar in males and females. Genetic factors accounted for 36% of the variance for hoarding and 40% of the variance for OCS. The genetic correlation between hoarding and OCS was 0.10. There was no evidence of sex-specific genetic contributions for hoarding or OCS. There was evidence for a genetic contribution to all hoarding symptom subtypes. Only cluttering showed evidence of a contribution from the shared environment.

Conclusions

OCS and hoarding are common in this population-based sample, have prevalence rates similar to those previously reported, and show significant heritability. Genetic factors contributed to the co-morbidity of both traits, although the genetic correlation between them was low.

Keywords

Geneticsheritabilityhoardingobsessive–compulsivetwins
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 13 , October 2014 , pp. 2867 - 2876
Copyright
Copyright © Cambridge University Press 2014 

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References

APA (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Association: Arlington,VA.Google Scholar
Ayers, CR, Saxena, S, Golshan, S, Wetherell, JL (2010). Age at onset and clinical features of late life compulsive hoarding. International Journal of Geriatric Psychiatry 25, 142–149.CrossRefGoogle ScholarPubMed
Best-Lavigniac, J (2006). Hoarding as an adult: overview and implications for practice. Journal of Psychosocial Nursing and Mental Health Services 44, 48–51.Google Scholar
Bolton, D, Rijsdijk, F, O'Connor, TG, Perrin, S, Eley, TC (2007). Obsessive–compulsive disorder, tics and anxiety in 6-year-old twins. Psychological Medicine 37, 39–48.CrossRefGoogle ScholarPubMed
Cath, DC, van Grootheest, DS, Willemsen, G, van Oppen, P, Boomsma, DI (2008). Environmental factors in obsessive–compulsive behavior: evidence from discordant and concordant monozygotic twins. Behavioral Genetics 38, 108–120.Google Scholar
Cromer, KR, Schmidt, NB, Murphy, DL (2007). Do traumatic events influence the clinical expression of compulsive hoarding? Behavior Research and Therapy 45, 2581–2592.CrossRefGoogle ScholarPubMed
Fontenelle, LF, Domingues, AM, Souza, WF, Mendlowicz, MV, de Menezes, GB, Figueira, IL, Versiani, M (2007). History of trauma and dissociative symptoms among patients with obsessive–compulsive disorder and social anxiety disorder. Psychiatric Quarterly 78, 241–250.Google Scholar
Frost, RO, Gross, RC (1993). The hoarding of possessions. Behavior Research and Therapy 31, 367–381.Google Scholar
Frost, RO, Steketee, G, Williams, L (2000 a). Hoarding: a community health problem. Health and Social Care in the Community 8, 229–234.CrossRefGoogle ScholarPubMed
Frost, RO, Steketee, G, Williams, LF, Warren, R (2000 b). Mood, personality disorder symptoms and disability in obsessive compulsive hoarders: a comparison with clinical and nonclinical controls. Behavior Research and Therapy 38, 1071–1081.Google Scholar
Grisham, JR, Frost, RO, Steketee, G, Kim, HJ, Hood, S (2006). Age of onset of compulsive hoarding. Journal of Anxiety Disorders 20, 675–686.CrossRefGoogle ScholarPubMed
Hartl, TL, Duffany, SR, Allen, GJ, Steketee, G, Frost, RO (2005). Relationships among compulsive hoarding, trauma, and attention-deficit/hyperactivity disorder. Behavior Research and Therapy 43, 269–276.CrossRefGoogle ScholarPubMed
Hudziak, JJ, Van Beijsterveldt, CE, Althoff, RR, Stanger, C, Rettew, DC, Nelson, EC, Todd, RD, Bartels, M, Boomsma, DI (2004). Genetic and environmental contributions to the Child Behavior Checklist Obsessive-Compulsive Scale: a cross-cultural twin study. Archives of General Psychiatry 61, 608–616.Google Scholar
Hur, YM, Jeong, HU (2008). Sex differences in genetic and environmental influences on obsessive compulsive symptoms in South Korean adolescent and young adult twins. Twin Research and Human Genetics 11, 314–320.CrossRefGoogle ScholarPubMed
Iervolino, AC, Perroud, N, Fullana, MA, Guipponi, M, Cherkas, L, Collier, DA, Mataix-Cols, D (2009). Prevalence and heritability of compulsive hoarding: a twin study. American Journal of Psychiatry 166, 1156–1161.Google Scholar
Iervolino, AC, Rijsdijk, FV, Cherkas, L, Fullana, MA, Mataix-Cols, D (2011). A multivariate twin study of obsessive–compulsive symptom dimensions. Archives of General Psychiatry 68, 637–644.CrossRefGoogle ScholarPubMed
Ivanov, VZ, Mataix-Cols, D, Serlachius, E, Lichtenstein, P, Anckarsäter, H, Chang, Z, Gumpert, CH, Lundström, S, Långström, N, Rück, C (2013). Prevalence, comorbidity and heritability of hoarding symptoms in adolescence: a population based twin study in 15-year olds. PLoS ONE 8, e69140.CrossRefGoogle Scholar
Jonnal, AH, Gardner, CO, Prescott, CA, Kendler, KS (2000). Obsessive and compulsive symptoms in a general population sample of female twins. American Journal of Medical Genetics 96, 791–796.3.0.CO;2-C>CrossRefGoogle Scholar
Katerberg, H, Delucchi, KL, Stewart, SE, Lochner, C, Denys, DA, Stack, DE, Andresen, JM, Grant, JE, Kim, SW, Williams, KA, den Boer, JA, van Balkom, AJ, Smit, JH, van Oppen, P, Polman, A, Jenike, MA, Stein, DJ, Mathews, CA, Cath, DC (2010). Symptom dimensions in OCD: item-level factor analysis and heritability estimates. Behavior Genetics 40, 505–517.CrossRefGoogle ScholarPubMed
Kim, HJ, Steketee, G, Frost, RO (2001). Hoarding by elderly people. Health and Social Work 26, 176–184.CrossRefGoogle ScholarPubMed
Landau, D, Iervolino, AC, Pertusa, A, Santo, S, Singh, S, Mataix-Cols, D (2011). Stressful life events and material deprivation in hoarding disorder. Journal of Anxiety Disorders 25, 192–202.Google Scholar
Lochner, C, Kinnear, CJ, Hemmings, SM, Seller, C, Niehaus, DJ, Knowles, JA, Daniels, W, Moolman-Smook, JC, Seedat, S, Stein, DJ (2005). Hoarding in obsessive–compulsive disorder: clinical and genetic correlates. Journal of Clinical Psychiatry 66, 1155–1160.Google Scholar
Mataix-Cols, D, Boman, M, Monzani, B, Ruck, C, Serlachius, E, Langstrom, N, Lichtenstein, P (2013). Population-based, multigenerational family clustering study of obsessive compulsive disorder. JAMA Psychiatry 70, 709–717.CrossRefGoogle ScholarPubMed
Mataix-Cols, D, Frost, RO, Pertusa, A, Clark, LA, Saxena, S, Leckman, JF, Stein, DJ, Matsunaga, H, Wilhelm, S (2010). Hoarding disorder: a new diagnosis for DSM-V? Depression and Anxiety 27, 556–572.Google Scholar
Mathews, CA, Kaur, N, Stein, MB (2008). Childhood trauma and obsessive–compulsive symptoms. Depression and Anxiety 25, 742–751.Google Scholar
Mathews, CA, Nievergelt, CM, Azzam, A, Garrido, H, Chavira, DA, Wessel, J, Bagnarello, M, Reus, VI, Schork, NJ (2007). Heritability and clinical features of multigenerational families with obsessive–compulsive disorder and hoarding. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 144, 174–182.Google Scholar
Nordsletten, AE, Monzani, B, Fernández de la Cruz, L, Iervolino, AC, Fullana, MA, Harris, J, Rijsdijk, F, Mataix-Cols, D (2013). Overlap and specificity of genetic and environmental influences on excessive acquisition and difficulties discarding possessions: implications for hoarding disorder. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 162, 380–387.Google Scholar
Pertusa, A, Frost, RO, Fullana, MA, Samuels, J, Steketee, G, Tolin, D, Saxena, S, Leckman, JF, Mataix-Cols, D (2010). Refining the diagnostic boundaries of compulsive hoarding: a critical review. Clinical Psychology Review 30, 371–386.Google Scholar
Pertusa, A, Fullana, MA, Singh, S, Alonso, P, Menchón, JM, Mataix-Cols, D (2008). Compulsive hoarding: OCD symptom, distinct clinical syndrome, or both? American Journal of Psychiatry 165, 1289–1298.CrossRefGoogle ScholarPubMed
Prescott, CA (2004). Using the Mplus computer program to estimate models for continuous and categorical data from twins. Behavior Genetics 34, 17–40.CrossRefGoogle ScholarPubMed
Samuels, J, Bienvenu, OJ 3rd, Riddle, MA, Cullen, BA, Grados, MA, Liang, KY, Hoehn-Saric, R, Nestadt, G (2002). Hoarding in obsessive compulsive disorder: results from a case–control study. Behavior Research and Therapy 40, 517–528.Google Scholar
Samuels, JF, Bienvenu, OJ 3rd, Pinto, A, Fyer, AJ, McCracken, JT, Rauch, SL, Murphy, DL, Grados, MA, Greenberg, BD, Knowles, JA, Piacentini, J, Cannistraro, PA, Cullen, B, Riddle, MA, Rasmussen, SA, Pauls, DL, Willour, VL, Shugart, YY, Liang, KY, Hoehn-Saric, R, Nestadt, G (2007). Hoarding in obsessive–compulsive disorder: results from the OCD Collaborative Genetics Study. Behavior Research and Therapy 45, 673–686.Google Scholar
Saxena, S (2007). Is compulsive hoarding a genetically and neurobiologically discrete syndrome? Implications for diagnostic classification. American Journal of Psychiatry 164, 380–384.CrossRefGoogle ScholarPubMed
Steketee, G, Frost, R (2003). Compulsive hoarding: current status of the research. Clinical Psychology Review 23, 905–927.Google Scholar
Taylor, S, Jang, KL, Asmundson, GJ (2010). Etiology of obsessions and compulsions: a behavioral–genetic analysis. Journal of Abnormal Psychology 119, 672–682.Google Scholar
Timpano, KR, Exner, C, Glaesmer, H, Rief, W, Keshaviah, A, Brähler, E, Wilhelm, S (2011). The epidemiology of the proposed DSM-5 hoarding disorder: exploration of the acquisition specifier, associated features, and distress. Journal of Clinical Psychiatry 72, 780–786; quiz 878–879.Google Scholar
Tolin, DF, Frost, RO, Steketee, G (2007). An open trial of cognitive–behavioral therapy for compulsive hoarding. Behavior Research and Therapy 45, 1461–1470.CrossRefGoogle ScholarPubMed
Tolin, DF, Frost, RO, Steketee, G (2010). A brief interview for assessing compulsive hoarding: the Hoarding Rating Scale-Interview. Psychiatry Research 178, 147–152.CrossRefGoogle ScholarPubMed
Tolin, DF, Frost, RO, Steketee, G, Fitch, KE (2008). Family burden of compulsive hoarding: results of an Internet survey. Behavior Research and Therapy 46, 334–344.Google Scholar
van Grootheest, DS, Bartels, M, van Beijsterveldt, CE, Cath, DC, Beekman, AT, Hudziak, JJ, Boomsma, DI (2008). Genetic and environmental contributions to self-report obsessive–compulsive symptoms in Dutch adolescents at ages 12, 14, and 16. Journal of the American Academy of Child and Adolescent Psychiatry 47, 1182–1188.Google Scholar
van Grootheest, DS, Cath, DC, Beekman, AT, Boomsma, DI (2005). Twin studies on obsessive–compulsive disorder: a review. Twin Research and Human Genetics 8, 450–458.Google Scholar
van Grootheest, DS, Cath, DC, Beekman, AT, Boomsma, DI (2007). Genetic and environmental influences on obsessive–compulsive symptoms in adults: a population-based twin-family study. Psychological Medicine 37, 1635–1644.Google Scholar
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