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The Nottingham Study of Neurotic Disorder: relationship between personality status and symptoms

Published online by Cambridge University Press:  09 July 2009

P. Tyrer ,
N. Seivewright ,
B. Ferguson ,
S. Murphy ,
C. Darling ,
J. Brothwell ,
D. Kingdon  and
A. L. Johnson
P. Tyrer*
Affiliation:
Mapperley Hospital, Nottingham and MRC Biostatistics Unit, Cambridge
N. Seivewright
Affiliation:
Mapperley Hospital, Nottingham and MRC Biostatistics Unit, Cambridge
B. Ferguson
Affiliation:
Mapperley Hospital, Nottingham and MRC Biostatistics Unit, Cambridge
S. Murphy
Affiliation:
Mapperley Hospital, Nottingham and MRC Biostatistics Unit, Cambridge
C. Darling
Affiliation:
Mapperley Hospital, Nottingham and MRC Biostatistics Unit, Cambridge
J. Brothwell
Affiliation:
Mapperley Hospital, Nottingham and MRC Biostatistics Unit, Cambridge
D. Kingdon
Affiliation:
Mapperley Hospital, Nottingham and MRC Biostatistics Unit, Cambridge
A. L. Johnson
Affiliation:
Mapperley Hospital, Nottingham and MRC Biostatistics Unit, Cambridge
*
1Address for correspondence: Dr P. Tyrer, St. Charles Hospital, London, W10 6DZ.
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Synopsis

Two hundred and ten psychiatric patients with one of three DSM-III diagnoses, generalized anxiety disorder (N = 71), panic disorder (N = 74) or dysthymic disorder (N = 65), were included in a clinical trial in which diazepam, dothiepin or placebo tablets, cognitive and behaviour therapy, or a self-help package were given over ten weeks. Personality status was assessed independently using a structured interview, the Personality Assessment Schedule. One hundred and ninety-eight patients had personality assessments, 89% with a close informant. Thirty-six per cent had a personality disorder and these patients had more severe psychopathology than those with no personality disorder. Personality disorder was more common in patients with dysthymic disorder and this group responded less well to treatment. The category of personality disorder had no apparent influence on symptoms.

Type
Original Articles
Information
Psychological Medicine , Volume 20 , Issue 2 , May 1990 , pp. 423 - 431
Copyright
Copyright © Cambridge University Press 1990

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