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Intranasal oxytocin increases facial expressivity, but not ratings of trustworthiness, in patients with schizophrenia and healthy controls

Published online by Cambridge University Press:  16 January 2017

J. D. Woolley ,
B. Chuang ,
C. Fussell ,
S. Scherer ,
B. Biagianti ,
D. Fulford ,
D. H. Mathalon  and
S. Vinogradov
J. D. Woolley*
Affiliation:
Department of Psychiatry, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
B. Chuang
Affiliation:
Department of Psychiatry, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
C. Fussell
Affiliation:
Department of Psychiatry, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
S. Scherer
Affiliation:
Institute for Creative Technologies, University of Southern California, Los Angeles, CA, USA
B. Biagianti
Affiliation:
Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
D. Fulford
Affiliation:
Departments of Occupational Therapy and Psychological & Brain Sciences, Boston University, Boston, MA, USA
D. H. Mathalon
Affiliation:
Department of Psychiatry, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
S. Vinogradov
Affiliation:
Department of Psychiatry, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
*
*Address for correspondence: J. Woolley, M.D./Ph.D., Department of Psychiatry, University of California San Francisco, 4150 Clement Street, 116C-1, San Francisco, CA 94121, USA. (Email: [email protected])
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Abstract

Background

Blunted facial affect is a common negative symptom of schizophrenia. Additionally, assessing the trustworthiness of faces is a social cognitive ability that is impaired in schizophrenia. Currently available pharmacological agents are ineffective at improving either of these symptoms, despite their clinical significance. The hypothalamic neuropeptide oxytocin has multiple prosocial effects when administered intranasally to healthy individuals and shows promise in decreasing negative symptoms and enhancing social cognition in schizophrenia. Although two small studies have investigated oxytocin's effects on ratings of facial trustworthiness in schizophrenia, its effects on facial expressivity have not been investigated in any population.

Method

We investigated the effects of oxytocin on facial emotional expressivity while participants performed a facial trustworthiness rating task in 33 individuals with schizophrenia and 35 age-matched healthy controls using a double-blind, placebo-controlled, cross-over design. Participants rated the trustworthiness of presented faces interspersed with emotionally evocative photographs while being video-recorded. Participants’ facial expressivity in these videos was quantified by blind raters using a well-validated manualized approach (i.e. the Facial Expression Coding System; FACES).

Results

While oxytocin administration did not affect ratings of facial trustworthiness, it significantly increased facial expressivity in individuals with schizophrenia (Z = −2.33, p = 0.02) and at trend level in healthy controls (Z = −1.87, p = 0.06).

Conclusions

These results demonstrate that oxytocin administration can increase facial expressivity in response to emotional stimuli and suggest that oxytocin may have the potential to serve as a treatment for blunted facial affect in schizophrenia.

Keywords

Blunted affectfacial expressivityoxytocinschizophreniasocial cognitiontrustworthiness
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 7 , May 2017 , pp. 1311 - 1322
Copyright
Copyright © Cambridge University Press 2017 

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