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The influence of propranolol on the exposure in vivo of agoraphobics

Published online by Cambridge University Press:  09 July 2009

Julian Hafner  and
Frank Milton
Julian Hafner*
Affiliation:
Kingston Hospital, Kingston-on-Thames, Surrey
Frank Milton
Affiliation:
Kingston Hospital, Kingston-on-Thames, Surrey
*
1Address for correspondence: Dr Julian Hafner, Clare House, St George's Hospital Medical School, Blackshaw Road, london SW17 0QT.
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Synopsis

This study examines the influence of 40 mg of propranolol on agoraphobics throughout 5-hour periods of exposure in vivo on 3 alternate days. Twenty-three patients were studied using a double-blind parallel design and 19 followed up for 3 months. The propranolol group spent significantly less time than the placebo group travelling alone in the month after treatment, and had improved significantly less on a measure of general symptoms at 3 months. The adverse influence of propranolol on treatment outcome appeared mainly due to a waning effect in the last hour of exposure. Attempts to measure coping with panics as an independent variable were largely unsuccessful.

Type
Research Article
Information
Psychological Medicine , Volume 7 , Issue 3 , August 1977 , pp. 419 - 425
Copyright
Copyright © Cambridge University Press 1977

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References

Caine, T. M. & Hope, K. (1967). The Manual of the Hysteroid-Obsessoid Questionnaire. University of London Press.Google Scholar
Caine, T. M., Foulds, G. A. & Hope, K. (1967). The Manual of the Hostility and Direction of Hostility Questionnaire (HDHQ). University of London Press.Google Scholar
Crown, S. & Crisp, A. H. (1966). A short clinical diagnostic self-rating scale for psychoneurotic patients. British Journal of Psychiatry 112, 917–923.Google Scholar
Hafner, R. J. & Marks, I. M. (1976). Exposure in vivo of agoraphobics: contributions of diazepam, group exposure and anxiety evocation. Psychological Medicine 6, 71–88.CrossRefGoogle ScholarPubMed
Jefferson, J. W. (1974). Beta-adrenergic receptor blocking drugs in psychiatry. Archives of General Psychiatry 31, 681–691.Google Scholar
Marks, I. M. (1970). Agoraphobic syndrome. Archives of General Psychiatry 23, 538–553.Google Scholar
Marks, I. M. & Herst, E. R. (1970). A survey of 1200 agoraphobics in Britain. Social Psychiatry 5, 16–24.Google Scholar