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Genetic and environmental influences on gambling disorder liability: a replication and combined analysis of two twin studies

Published online by Cambridge University Press:  30 August 2018

Christal N. Davis Open the ORCID record for Christal N. Davis [Opens in a new window] ,
Wendy S. Slutske ,
Nicholas G. Martin ,
Arpana Agrawal  and
Michael T. Lynskey
Christal N. Davis
Affiliation:
University of Missouri, Columbia, MO, USA
Wendy S. Slutske*
Affiliation:
University of Missouri, Columbia, MO, USA
Nicholas G. Martin
Affiliation:
QIMR Berghofer, Brisbane, Queensland, Australia
Arpana Agrawal
Affiliation:
Washington University School of Medicine, St. Louis, MO, USA
Michael T. Lynskey
Affiliation:
King's College London Institute of Psychiatry, Psychology & Neuroscience, London, UK
*
Author for correspondence: Wendy S. Slutske, E-mail: [email protected]
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Abstract

Background

Gambling disorder (GD), recognized in Diagnostic and Statistical Manual of Mental Disorders, Version 5 (DSM-5) as a behavioral addiction, is associated with a range of adverse outcomes. However, there has been little research on the genetic and environmental influences on the development of this disorder. This study reports results from the largest twin study of GD conducted to date.

Methods

Replication and combined analyses were based on samples of 3292 (mean age 31.8, born 1972–79) and 4764 (mean age 37.7, born 1964–71) male, female, and unlike-sex twin pairs from the Australian Twin Registry. Univariate biometric twin models estimated the proportion of variation in the latent GD liability that could be attributed to genetic, shared environmental, and unique environmental factors, and whether these differed quantitatively or qualitatively for men and women.

Results

In the replication study, when using a lower GD threshold, there was evidence for significant genetic (60%; 95% confidence interval (CI) 45–76%) and unique environmental (40%; 95% CI 24–56%), but not shared environmental contributions (0%; 95% CI 0–0%) to GD liability; this did not significantly differ from the original study. In the combined analysis, higher GD thresholds (such as one consistent with DSM-5 GD) and a multiple threshold definitions of GD yielded similar results. There was no evidence for quantitative or qualitative sex differences in the liability for GD.

Conclusions

Twin studies of GD are few in number but they tell a remarkably similar story: substantial genetic and unique environmental influences, with no evidence for shared environmental contributions or sex differences in GD liability.

Keywords

Behavioral geneticsgambling disordersex differencestwins
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 10 , July 2019 , pp. 1705 - 1712
Copyright
Copyright © Cambridge University Press 2018 

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