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Familial influence and childhood trauma in female alcoholism

Published online by Cambridge University Press:  29 July 2011

Å. Magnusson ,
C. Lundholm ,
M. Göransson ,
W. Copeland ,
M. Heilig  and
N. L. Pedersen
Å. Magnusson*
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
C. Lundholm
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
M. Göransson
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
W. Copeland
Affiliation:
Center for Developmental Epidemiology, Duke University, Durham, NC, USA
M. Heilig
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
N. L. Pedersen
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
*
*Address for correspondence: Å. Magnusson, M.D., Ph.D., I 66, BCS (The Center for Dependence Disorders in Stockholm), Karolinska Universitetssjukhuset, Huddinge, 141 86 Stockholm, Sweden. (Email: [email protected])
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Abstract

Background

To assess the role of genetic and environmental factors in female alcoholism using a large population-based twin sample, taking into account possible differences between early and late onset disease subtype.

Method

Twins aged 20–47 years from the Swedish Twin Registry (n=24 119) answered questions to establish lifetime alcohol use disorders. Subjects with alcoholism were classified for subtype. Structural equation modeling was used to quantify the proportion of phenotypic variance due to genetic and environmental factors and test whether heritability in women differed from that in men. The association between childhood trauma and alcoholism was then examined in females, controlling for background familial factors.

Results

Lifetime prevalence of alcohol dependence was 4.9% in women and 8.6% in men. Overall, heritability for alcohol dependence was 55%, and did not differ significantly between men and women, although women had a significantly greater heritability for late onset (type I). Childhood physical trauma and sexual abuse had a stronger association with early onset compared to late onset alcoholism [odds ratio (OR) 2.54, 95% confidence interval (CI) 1.53–3.88 and OR 2.29, 95% CI 1.38–3.79 respectively]. Co-twin analysis indicated that familial factors largely accounted for the influence of physical trauma whereas the association with childhood sexual abuse reflected both familial and specific effects.

Conclusions

Heritability of alcoholism in women is similar to that in men. Early onset alcoholism is strongly association with childhood trauma, which seems to be both a marker of familial background factors and a specific individual risk factor per se.

Keywords

Alcohol dependencechildhood traumaearly onsetfemale twinsheritability
Type
Original Articles
Information
Psychological Medicine , Volume 42 , Issue 2 , February 2012 , pp. 381 - 389
Copyright
Copyright © Cambridge University Press 2011

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References

Bohman, M, Cloninger, R, Sigvardsson, S, von Knorring, AL (1987). The genetics of alcoholisms and related disorders. Journal of Psychiatric Research 21, 447–452.CrossRefGoogle ScholarPubMed
Brienza, RS, Stein, MD (2002). Alcohol use disorders in primary care: do gender-specific differences exist? Journal of General Internal Medicine 17, 387–397.Google ScholarPubMed
Bulik, CM, Prescott, CA, Kendler, KS (2001). Features of childhood sexual abuse and the development of psychiatric and substance use disorders. British Journal of Psychiatry 179, 444–449.CrossRefGoogle ScholarPubMed
Cloninger, CR, Bohman, M, Sigvardsson, S (1981). Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Archives of General Psychiatry 38, 861–868.CrossRefGoogle ScholarPubMed
Dinwiddie, S, Heath, AC, Dunne, MP, Bucholz, KK, Madden, PA, Slutske, WS, Bierut, LJ, Statham, DB, Martin, NG (2000). Early sexual abuse and lifetime psychopathology: a co-twin–control study. Psychological Medicine 30, 41–52.CrossRefGoogle ScholarPubMed
Dube, SR, Miller, JW, Brown, DW, Giles, WH, Felitti, VJ, Dong, M, Anda, RF (2006). Adverse childhood experiences and the association with ever using alcohol and initiating alcohol use during adolescence. Journal of Adolescent Health 38, 444–410.CrossRefGoogle ScholarPubMed
Ducci, F, Enoch, MA, Hodgkinson, C, Xu, K, Catena, M, Robin, RW, Goldman, D (2008). Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Molecular Psychiatry 13, 334–347.CrossRefGoogle ScholarPubMed
Ducci, F, Goldman, D (2008). Genetic approaches to addiction: genes and alcohol. Addiction 103, 1414–1428.CrossRefGoogle ScholarPubMed
First, MB, Spitzer, RL, Gibbon, M, Williams, JBW (1997). Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version. American Psychiatric Press: Washington, DC.Google Scholar
Gilligan, SB, Reich, T, Cloninger, CR (1988). Alcohol-related symptoms in heterogeneous families of hospitalized alcoholics. Alcoholism: Clinical and Experimental Research 12, 671–678.CrossRefGoogle ScholarPubMed
Goldman, D, Oroszi, G, Ducci, F (2005). The genetics of addictions: uncovering the genes. Nature Reviews Genetics 6, 521–532.CrossRefGoogle ScholarPubMed
Grant, BF, Dawson, DA (1997). Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. Journal of Substance Abuse 9, 103–110.CrossRefGoogle ScholarPubMed
Heath, AC, Bucholz, KK, Madden, PAF, Dinwiddie, SH, Slutske, WS, Bierut, LJ, Statham, DJ, Dunne, MP, Whitfield, JB, Martin, NG (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychological Medicine 27, 1381–1396.CrossRefGoogle Scholar
Hopfer, CJ, Crowley, TJ, Hewitt, JK (2003). Review of twin and adoption studies of adolescent substance use. Journal of the American Academy of Child and Adolescent Psychiatry 42, 710–719.CrossRefGoogle ScholarPubMed
Hunter, DJ (2005). Gene-environment interactions in human diseases. Nature Reviews Genetics 6, 287–298.CrossRefGoogle ScholarPubMed
Kendler, KS, Bulik, CM, Silberg, J, Hettema, JM, Myers, J, Prescott, CA (2000). Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Archives of General Psychiatry 57, 953–959.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC, Kessler, RC, Heath, AC, Eaves, LJ (1993). A test of the equal-environment assumption in twin studies of psychiatric illness. Behavior Genetics 23, 21–27.CrossRefGoogle ScholarPubMed
Kim-Cohen, J, Caspi, A, Taylor, A, Williams, B, Newcombe, R, Craig, IW, Moffitt, TE (2006). MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis. Molecular Psychiatry 11, 903–913.CrossRefGoogle ScholarPubMed
Kimerling, R, Clum, GA, Wolfe, J (2000). Relationships among trauma exposure, chronic posttraumatic stress disorder symptoms, and self-reported health in women: replication and extension. Journal of Traumatic Stress 13, 115–128.CrossRefGoogle ScholarPubMed
Lichtenstein, P, De Faire, U, Floderus, B, Svartengren, M, Svedberg, P, Pedersen, NL (2002). The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. Journal of Internal Medicine 252, 184–205.CrossRefGoogle ScholarPubMed
Magnusson, A, Goransson, M, Heilig, M (2005). Unexpectedly high prevalence of alcohol use among pregnant Swedish women: failed detection by antenatal care and simple tools that improve detection. Journal of Studies on Alcohol 66, 157–164.CrossRefGoogle ScholarPubMed
Magnusson, A, Goransson, M, Heilig, M (2010). Early onset alcohol dependence with high density of family history is not ‘male limited’. Alcohol 44, 131–139.CrossRefGoogle Scholar
McCauley, J, Kern, DE, Kolodner, K, Dill, L, Schroeder, AF, DeChant, HK, Ryden, J, Derogatis, LR, Bass, EB (1997). Clinical characteristics of women with a history of childhood abuse: unhealed wounds. Journal of the American Medical Association 277, 1362–1368.CrossRefGoogle ScholarPubMed
Neale, MC, Boker, SM, Xie, G, Maes, H (2003). Mx: Statistical Modeling. Department of Psychiatry, Virginia Commonwealth University: Richmond, VA.Google Scholar
Nelson, EC, Heath, AC, Madden, PA, Cooper, ML, Dinwiddie, SH, Bucholz, KK, Glowinski, A, McLaughlin, T, Dunne, MP, Statham, DJ, Martin, NG (2002). Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study. Archives of General Psychiatry 59, 139–145.CrossRefGoogle ScholarPubMed
Pirard, S, Sharon, E, Kang, SK, Angarita, GA, Gastfriend, DR (2005). Prevalence of physical and sexual abuse among substance abuse patients and impact on treatment outcomes. Drug and Alcohol Dependence 78, 57–64.CrossRefGoogle ScholarPubMed
Prescott, CA, Caldwell, CB, Carey, G, Vogler, GP, Trumbetta, SL, Gottesman, II (2005). The Washington University Twin Study of alcoholism. American Journal of Medical Genetics (Neuropsychiatric Genetics) 134B, 48–55.CrossRefGoogle ScholarPubMed
Prescott, CA, Kendler, KS (1999). Age at first drink and risk for alcoholism: a noncausal association. Alcoholism: Clinical and Experimental Research 23, 101–107.Google ScholarPubMed
Sartor, CE, Agrawal, A, McCutcheon, VV, Duncan, AE, Lynskey, MT (2008). Disentangling the complex association between childhood sexual abuse and alcohol-related problems: a review of methodological issues and approaches. Journal of Studies on Alcohol 69, 718–727.Google ScholarPubMed
Sartor, CE, Lynskey, MT, Bucholz, KK, McCutcheon, VV, Nelson, EC, Waldron, M, Heath, AC (2007). Childhood sexual abuse and the course of alcohol dependence development: findings from a female twin sample. Drug and Alcohol Dependence 89, 139–144.CrossRefGoogle ScholarPubMed
Sher, KJ, Gershuny, BS, Peterson, L, Raskin, G (1997). The role of childhood stressors in the intergenerational transmission of alcohol use disorders. Journal of Studies on Alcohol 58, 414–427.CrossRefGoogle ScholarPubMed
Sheridan, MJ (1995). A proposed intergenerational model of substance abuse, family functioning, and abuse/neglect. Child Abuse and Neglect 19, 519–530.CrossRefGoogle ScholarPubMed
Shin, SH, Edwards, EM, Heeren, T (2009). Child abuse and neglect: relations to adolescent binge drinking in the national longitudinal study of Adolescent Health (AddHealth) Study. Addictive Behaviors 34, 277–280.CrossRefGoogle ScholarPubMed
Sigvardsson, S, Bohman, M, Cloninger, CR (1996). Replication of the Stockholm adoption study of alcoholism. Confirmatory cross-fostering analysis. Archives of General Psychiatry 53, 681–687.CrossRefGoogle ScholarPubMed
Simpson, TL, Miller, WR (2002). Concomitance between childhood sexual and physical abuse and substance use problems. A review. Clinical Psychology Review 22, 27–77.CrossRefGoogle ScholarPubMed
von Knorring, AL, Bohman, M, von Knorring, L, Oreland, L (1985). Platelet MAO activity as a biological marker in subgroups of alcoholism. Acta Psychiatrica Scandinavica 72, 51–58.CrossRefGoogle ScholarPubMed
Waldrop, AE, Ana, EJ, Saladin, ME, McRae, AL, Brady, KT (2007). Differences in early onset alcohol use and heavy drinking among persons with childhood and adulthood trauma. American Journal on Addictions 16, 439–442.CrossRefGoogle ScholarPubMed
Wilsnack, SC, Vogeltanz, ND, Klassen, AD, Harris, TR (1997). Childhood sexual abuse and women's substance abuse: national survey findings. Journal of Studies on Alcohol 58, 264–271.CrossRefGoogle ScholarPubMed
Windle, M, Scheidt, DM (2004). Alcoholic subtypes: are two sufficient? Addiction 99, 1508–1519.CrossRefGoogle ScholarPubMed
Wirdefeldt, K, Gatz, M, Pawitan, Y, Pedersen, NL (2005). Risk and protective factors for Parkinson's disease: a study in Swedish twins. Annals of Neurology 57, 27–33.CrossRefGoogle ScholarPubMed