Hostname: page-component-745bb68f8f-b95js Total loading time: 0 Render date: 2025-01-07T16:20:38.073Z Has data issue: false hasContentIssue false
  • English
  • Français

Factors influencing the occurrence of schizophrenia-like psychosis in patients with temporal lobe epilepsy

Published online by Cambridge University Press:  09 July 2009

David C. Taylor
David C. Taylor
Affiliation:
Human Development Research Unit, Park Hospital for Children, Oxford
Get access Rights & Permissions [Opens in a new window]

Synopsis

From a series of 255 patients who had undergone temporal lobectomy for the relief of intractable psychomotor epilepsy, all 47 patients with ‘alien tissue’ (small tumours, hamartomas, focal dysplasia) in the resected temporal lobe were contrasted with a group of 41 patients who showed mesial temporal sclerosis in their resected lobe. Five per cent of the mesial temporal sclerosis group and 23% of the alien tissue group were psychotic. A marked interaction occurred between psychosis and ‘left handedness’. In the alien tissue group, females, especially left-handed females, were the most likely to have developed a schizophrenia-like psychosis.

Type
Original Article
Information
Psychological Medicine , Volume 5 , Issue 3 , August 1975 , pp. 249 - 254
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cavanagh, J. B. (1958). On certain small tumours encountered in the temporal lobe. Brain, 81, 389–405.CrossRefGoogle ScholarPubMed
Currie, S., Heathfield, K. W. G., Henson, R. A., and Scott, D. F. (1971). Clinical course and prognosis of temporal lobe epilepsy. A survey of 666 patients. Brain, 94, 173–190.CrossRefGoogle ScholarPubMed
Falconer, M. A. (1965). The surgical treatment of temporal lobe epilepsy. Neurochirurgia, 8, 161–172.Google ScholarPubMed
Falconer, M. A. (1973). Reversibility by temporal-lobe resection of the behavioral abnormalities of temporal-lobe epilepsy. New England Journal of Medicine, 289, 451–455.CrossRefGoogle ScholarPubMed
Falconer, M. A., Hill, D., Meyer, A., Mitchell, W., and Pond, D. A. (1955). Treatment of temporal-lobe epilepsy by temporal lobectomy. A survey of findings and results. Lancet, 1, 827–835.CrossRefGoogle Scholar
Falconer, M. A., Serafetinides, E. A., and Corsellis, J. A. (1964). Etiology and pathogenesis of temporal lobe epilepsy. Archives of Neurology, 10, 233–248.CrossRefGoogle ScholarPubMed
Falconer, M. A., and Taylor, D. C. (1968). Surgical treatment of drug-resistant epilepsy due to mesial temporal sclerosis. Archives of Neurology, 19, 353–361.CrossRefGoogle ScholarPubMed
Flor-Henry, P. (1969). Psychosis and temporal lobe epilepsy. A controlled investigation. Epilepsia, 10, 363–395.CrossRefGoogle ScholarPubMed
Lancet (1974). Epilepsy, schizophrenia, and limbic system. Lancet, 2, 935–936.Google Scholar
McLardy, T. (1969). Ammon's horn pathology and epileptic dyscontrol. Nature, 221, 877–878.CrossRefGoogle ScholarPubMed
Malamud, N. (1967). Psychiatric disorder with intracranial tumors of the limbric system. Archives of Neurology, 17, 113–123.CrossRefGoogle ScholarPubMed
Meldrum, B. S., and Brierley, J. B. (1972). Neuronal loss and gliosis in the hippocampus following repetitive epileptic seizures induced in adolescent baboons by allylglycine. Brain Research, 48, 361–365.CrossRefGoogle ScholarPubMed
Mignone, R. J., Donnelly, E. F., and Sadowsky, D. (1970). Psychological and neurological comparisons of psychomotor and non-psychomotor epileptic patients. Epilepsia, 11, 345–359.CrossRefGoogle ScholarPubMed
Satz, P. (1972). Pathological left-handedness: an explanatory model. Cortex, 8, 121–135.CrossRefGoogle ScholarPubMed
Serafetinides, E. A., and Falconer, M. A. (1962). The effects of temporal lobectomy in epileptic patients with psychosis. Journal of Mental Science, 108, 584–593.CrossRefGoogle ScholarPubMed
Slater, E., Beard, A. W., and Glithero, E. (1963). The schizophrenia-like psychoses of epilepsy. British Journal of Psvchiatry, 109, 95–150.CrossRefGoogle Scholar
Small, J. G., Milstein, V., and Stevens, J. R. (1962). Are psychomotor epileptics different? A controlled study. Archives of Neurology, 7, 187–194.CrossRefGoogle ScholarPubMed
Small, J. G., Small, I. F., and Hayden, M. P. (1966). Further psychiatric investigations of patients with temporal and nontemporal lobe epilepsy. American Journal of Psychiatry, 123, 303–310.CrossRefGoogle ScholarPubMed
Taylor, D. C. (1971). Ontogenesis of epileptic psychoses: a reanalysis. Psychological Medicine, 1, 247–253.CrossRefGoogle ScholarPubMed
Taylor, D. C. (1972). Mental state and temporal lobe epilepsy. A correlative account of 100 patients treated surgically. Epilepsia, 13, 727–765.CrossRefGoogle ScholarPubMed
Taylor, D. C., and Falconer, M. A. (1968). Clinical, socioeconomic, and psychological changes after temporal lobectomy for epilepsy. British Journal of Psychiatry, 114, 1247–1261.CrossRefGoogle ScholarPubMed
Taylor, D. C., Falconer, M. A., Bruton, C. J., and Corsellis, J. A. N. (1971). Focal dysplasia of the cerebral cortex in epilepsy. Journal of Neurology, Neurosurgery, and Psychiatry, 34, 369–387.CrossRefGoogle ScholarPubMed