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Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia

Published online by Cambridge University Press:  12 August 2009

K. Ranft ,
H. Dobrowolny ,
D. Krell ,
H. Bielau ,
B. Bogerts  and
H.-G. Bernstein
K. Ranft
Affiliation:
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany Department of Neurology, University of Magdeburg, Magdeburg, Germany
H. Dobrowolny
Affiliation:
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
D. Krell
Affiliation:
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
H. Bielau
Affiliation:
Walter-Friedrich-Krankenhaus Olvenstedt, Magdeburg, Germany
B. Bogerts
Affiliation:
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
H.-G. Bernstein*
Affiliation:
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
*
*Address for correspondence: Prof. Dr H.-G. Bernstein, Department of Psychiatry, University of Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany. (Email: [email protected])
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Abstract

Background

The habenular complex is composed of important relay nuclei linking the limbic forebrain to the midbrain and brain stem nuclei. Based on clinical observations, experiments with animals and theoretical considerations, it has been speculated that this brain area might be involved in psychiatric diseases (i.e. schizophrenia and depression). However, evidence in favour of this hypothesis is still lacking because the human habenular complex has rarely been studied with regard to mental illness.

Method

We examined habenular volumes in post-mortem brains of 17 schizophrenia patients, 14 patients with depression (six patients with major depression and eight patients with bipolar depression) and 13 matched controls. We further determined the neuronal density, cell number and cell area of the medial habenular nuclei of the same cohorts using a counting box and a computer-assisted instrument.

Results

Significantly reduced habenular volumes of the medial and lateral habenula were estimated in depressive patients in comparison to normal controls and schizophrenia patients. We also found a reduction in neuronal cell number and cell area in depressive patients for the right side compared to controls and schizophrenia patients. No such changes were seen in schizophrenia.

Conclusions

Our anatomical data argue against prominent structural alterations of the habenular nuclei in schizophrenia but demonstrate robust alterations in depressive patients. We are currently applying immunohistochemical markers to better characterize neuronal subpopulations of this brain region in schizophrenia and depression.

Keywords

Affective disorderhabenulahuman brainmorphometryneuronal densityschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 40 , Issue 4 , April 2010 , pp. 557 - 567
Copyright
Copyright © Cambridge University Press 2009

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