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Error-related brain activity dissociates hoarding disorder from obsessive-compulsive disorder

Published online by Cambridge University Press:  29 September 2015

C. A. Mathews ,
V. B. Perez ,
B. J. Roach ,
S. Fekri ,
O. Vigil ,
E. Kupferman  and
D. H. Mathalon
C. A. Mathews*
Affiliation:
Department of Psychiatry, University of California, San Francisco, CA, USA Department of Psychiatry, University of Florida, Gainesville, FL, USA
V. B. Perez
Affiliation:
California School of Professional Psychology (CSPP), Alliant International University Department of Psychiatry, University of California, San Diego, CA, USA Veterans Integrated Service Network (VISN) 22, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA
B. J. Roach
Affiliation:
Department of Psychiatry, University of California, San Francisco, CA, USA San Francisco VA Medical Center, San Francisco, CA, USA
S. Fekri
Affiliation:
Department of Psychiatry, University of California, San Francisco, CA, USA
O. Vigil
Affiliation:
Department of Psychiatry, University of California, San Francisco, CA, USA
E. Kupferman
Affiliation:
Department of Psychiatry, University of California, San Francisco, CA, USA
D. H. Mathalon
Affiliation:
Department of Psychiatry, University of California, San Francisco, CA, USA San Francisco VA Medical Center, San Francisco, CA, USA
*
*Address for correspondence: C. A. Mathews, MD, Department of Psychiatry, University of Florida, 100 S. Newell Dr. L4-100, Gainesville, FL 32610, USA. (Email: [email protected])
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Abstract

Background

Obsessive-compulsive disorder (OCD) is associated with an abnormally large error-related negativity (ERN), an electrophysiological measure of error monitoring in response to performance errors, but it is unclear if hoarding disorder (HD) also shows this abnormality. This study aimed to determine whether the neurophysiological mechanisms underlying error monitoring are similarly compromised in HD and OCD.

Method

We used a visual flanker task to assess ERN in response to performance errors in 14 individuals with HD, 27 with OCD, 10 with HD+OCD, and 45 healthy controls (HC). Age-corrected performance and ERN amplitudes were examined using analyses of variance and planned pairwise group comparisons.

Results

A main effect of hoarding on ERN (p = 0.031) was observed, indicating ERN amplitudes were attenuated in HD relative to non-HD subjects. A group × age interaction effect on ERN was also evident. In HD-positive subjects, ERN amplitude deficits were significantly greater in younger individuals (r = −0.479, p = 0.018), whereas there were no significant ERN changes with increasing age in OCD and HC participants.

Conclusions

The reduced ERN in HD relative to OCD and HC provides evidence that HD is neurobiologically distinct from OCD, and suggests that deficient error monitoring may be a core pathophysiological feature of HD. This effect was particularly prominent in younger HD participants, further suggesting that deficient error monitoring manifests most strongly early in the illness course and/or in individuals with a relatively early illness onset.

Keywords

Electroencephalography/event-related potentials (EEG/ERP)error monitoringerror-related negativity (ERN)hoardingneurophysiologicalobsessive-compulsive disorder (OCD)
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 2 , January 2016 , pp. 367 - 379
Copyright
Copyright © Cambridge University Press 2015 

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