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Emotional disturbance following childbirth: clinical findings and urinary excretion of cyclic AMP (adenosine 3'5' cyclic monophosphate)

Published online by Cambridge University Press:  09 July 2009

C. Barbara Ballinger ,
Dorothy E. Buckley ,
Graham J. Naylor  and
David A. Stansfield
C. Barbara Ballinger*
Affiliation:
Department of Psychiatry, Nine wells Hospital and Medical School, Dundee, and the Departments of Psychiatry and Biochemistry, University of Dundee
Dorothy E. Buckley
Affiliation:
Department of Psychiatry, Nine wells Hospital and Medical School, Dundee, and the Departments of Psychiatry and Biochemistry, University of Dundee
Graham J. Naylor
Affiliation:
Department of Psychiatry, Nine wells Hospital and Medical School, Dundee, and the Departments of Psychiatry and Biochemistry, University of Dundee
David A. Stansfield
Affiliation:
Department of Psychiatry, Nine wells Hospital and Medical School, Dundee, and the Departments of Psychiatry and Biochemistry, University of Dundee
*
1Address for correspondence: Dr C. B. Ballinger, Department of Psychiatry, Ninewells Hospital, Dundee.
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Synopsis

Emotional disturbance was assessed in a group of women in the first few days following childbirth and again 2 months and 1 year following childbirth; the clinical features are described. Variables such as social class, age and parity were not related to the level of emotional disturbance, but a history of marital problems, sexual difficulties, poor relationships with immediate family or disrupted family relationships in childhood were so related.

Twenty-four hour urinary excretion of cyclic AMP (adenosine 3' 5' cyclic monophosphate) was estimated in the same group of women on 2 occasions in the week following childbirth and again 2—3 months later in approximately one third of the original sample. Excretion of cyclic AMP in the few days following delivery was elevated compared with excretion 2—3 months later, and there was a significant rise in urinary excretion of cyclic AMP between the 1st and 2nd urine collections.

Those women showing most emotional disturbance on the 3rd day after delivery and women indicating most mood change in the direction of becoming elated had the highest levels of cyclic AMP in the 2nd urine collection.

Type
Research Article
Information
Psychological Medicine , Volume 9 , Issue 2 , May 1979 , pp. 293 - 300
Copyright
Copyright © Cambridge University Press 1979

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References

Abdulla, Y. H. & Hamadah, K. (1970). 3'5' cyclic adenosine monophosphate in depression and mania. Lancet i, 378–381.Google Scholar
Bousnes, R. W. & Taussky, H. H. (1945). On the colorimetric determination of creatinine by the Jaffe reaction. Journal of Biological Chemistry 158, 581–591.Google Scholar
Broadus, A. E. (1977). Clinical cyclic nucleotide research. In Advances in Cyclic Nucleotide Research Vol. 8 (ed. Greengard, P. and Robinson, G. A.), pp. 509–549. Raven Press: New York.Google Scholar
Broadus, A. E., Kaminsky, N. I., Hardman, J. G. & Sutherland, E. W. (1970). Kinetic parameters and renal clearance of plasma adenosine 3'5' monophosphate and guanosine 3'5' monophosphate in man. Journal of Clinical Investigation 49, 2222–2236.CrossRefGoogle ScholarPubMed
Brown, G. W., Bhrolchain, M. N. & Harris, T. (1975). Social class and psychiatric disturbance among women in an urban population. Sociology 9, 225–254.CrossRefGoogle Scholar
Cooper, A. J. (1969). Some personality factors in frigidity. Journal of Psychosomatic Research 13, 149–155.CrossRefGoogle ScholarPubMed
Cooper, B. (1972). Clinical and social aspects of chronic neurosis. Proceedings of the Royal Society of Medicine 65, 509–512.CrossRefGoogle ScholarPubMed
Coppen, A. (1965). The prevalence of menstrual disorders in psychiatric patients. British Journal of Psychiatry 111, 155–167.Google Scholar
Dalton, K. (1971). Prospective study into puerperal depression. British Journal of Psychiatry 118, 689–692.CrossRefGoogle ScholarPubMed
Eccleston, D., Loose, R., Pullar, I. A. & Sugden, R. F. (1970). Exercise and urinary excretion of cyclic AMP. Lancet ii, 612–613.CrossRefGoogle Scholar
Goldberg, D. P. (1972). The Detection of Psychiatric Illness by Questionnaire. Oxford University Press: London.Google Scholar
Goldberg, D. P. & Blackwell, B. (1970). Psychiatric illness in general practice: a detailed study using a new method of case identification. British Medical Journal ii, 439–443.CrossRefGoogle Scholar
Goldberg, D. P., Cooper, B., Eastwood, M. R., Kedward, H. B. & Shepherd, M. (1970). A standardised psychiatric interview for use in community surveys. British Journal of Preventive and Social Medicine 24, 18–23.Google Scholar
Goldberg, D. P., Kay, C. & Thompson, L. (1976). Psychiatric morbidity in general practice and the community. Psychological Medicine 6, 565–569.CrossRefGoogle ScholarPubMed
Greengard, P., MacAfee, D. A. & Kebabian, J. W. (1972). On the mechanism of action of cyclic AMP and its role in synaptic transmission. In Advances in Cyclic Nucleotide Research Vol. 1 (ed. Greengard, P. and Robinson, G. A.), pp. 337–355. Raven Press: New York.Google Scholar
Grundy, P. F. & Roberts, C. J. (1975). Observations on the epidemiology of postpartum mental illness. Psychological Medicine 5, 286–290.CrossRefGoogle Scholar
Hamadah, K., Holmes, H., Stokes, M. L., Hartman, G. C. & Parke, D. V. (1974). Variation in urinary cyclic AMP content during the human menstrual cycle. Biochemical Society Transactions 2, 461–462.Google Scholar
Handley, S. L., Dunn, T. L., Baker, J. M., Cockshott, C. & Gould, S. (1977). Mood changes in puerperium and plasma tryptophan and cortisol concentrations. British Medical Journal ii, 18–22.CrossRefGoogle Scholar
Kaij, L. & Nilsson, Å. (1972). Emotional and psychotic illness following childbirth. In Modern Perspectives in Psycho Obstetrics (ed. Morris, N.), pp. 364–384. Oliver and Boyd: Edinburgh.Google Scholar
Kane, F. J., Harman, W. J., Keeler, M. H. & Ewing, J. A. (1968). Emotional and cognitive disturbance in the early puerperium. British Journal of Psychiatry 114, 99–102.CrossRefGoogle ScholarPubMed
Kendell, R. E., Wainwright, S., Hailey, A. & Shannon, B. (1976). The influence of childbirth on psychiatric morbidity. Psychological Medicine 6, 297–302.Google Scholar
Lomas, P. (1959). The husband–wife relationship in cases of puerperal breakdown. British Journal of Medical Psychology 32, 117–123.Google Scholar
Marsh, J. M., Butcher, R. W., Savard, K. & Sutherland, E. W. (1966). The stimulatory effect of luteinising hormone on adenosine 3ά5ά monophosphate accumulation in corpus luteum slices. Journal of Biological Chemistry 241, 5436–5440.CrossRefGoogle Scholar
Naylor, G. J., Stansfield, D. A., Whyte, S. F. & Hutchinson, F. (1974). Urinary excretion of adenosine 3ά5ά cyclic mono- phosphate in depressive illness. British Journal of Psychiatry 125, 275–279.CrossRefGoogle Scholar
Nilsson, Å. & Almgren, P. R. (1968). Psychiatric symptoms during the postpartum period as related to use of oral contraceptives. British Medical Journal ii, 453–455.Google Scholar
Nott, P. N., Franklin, M., Armitage, C. & Gelder, M. G. (1976). Hormonal changes and mood in the puerperium. British Journal of Psychiatry 128, 379–383.CrossRefGoogle ScholarPubMed
Paffenberger, R. S. (1964). Epidemiological aspects of parapartum mental illness. British Journal of Preventive and Social Medicine 18, 189–195.Google Scholar
Pastan, I. & Perlman, R. (1970). Cyclic adenosine mono- phosphate in bacteria. Science 169, 339–344.Google Scholar
Paul, M. I., Ditzion, B. R., Pauk, G. L. & Janowsky, D. S. (1970). Adenosine 3'5' monophosphate excretion in affective disorders. American Journal of Psychiatry 126, 1493–1497.Google Scholar
Pitt, B. (1968). ‘Atypical’ depression following childbirth. British Journal of Psychiatry 114, 1325–1335.CrossRefGoogle ScholarPubMed
Pitt, B. (1973). ‘Maternity blues’. British Journal of Psychiatry 122, 431–433.CrossRefGoogle ScholarPubMed
Pitt, B. (1975). The aftermath of childbirth. Proceedings of the Royal Society of Medicine 68, 223–224.Google Scholar
Sinanan, K., Keatinge, A. M. B., Beckett, P. G. S. & Clayton Love, W. (1975). Urinary cyclic AMP in ‘endogenous’ and ‘neurotic’ depression. British Journal of Psychiatry 126, 49–55.Google Scholar
Stein, G., Milton, F., Bebbington, P., Wood, K. & Coppen, A. (1976). Relationships between mood disturbances and free and total plasma tryptophan in postpartum women. British Medical Journal ii, 457.CrossRefGoogle Scholar
Tomlinson, S., Barling, P. M., Albano, J. D. M., Brown, B. L. & O'Riordan, J. L. H. (1974). The effects of exogenous parathyroid hormone on plasma and urinary adenosine 3'5' cyclic monophosphate in man. Clinical Science and Molecular Medicine 47, 481–492.Google Scholar
Yalom, I. D., Lunde, D. T., Moos, R. H. & Hamburg, D. A. (1968). ‘Postpartum blues’ syndrome. Archives of General Psychiatry 18, 16–27.Google Scholar
Zealley, A. K. & Aitken, R. C. B. (1969). Measurement of mood. Proceedings of the Royal Society of Medicine 62, 993–996.CrossRefGoogle ScholarPubMed