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Efficacy of cognitive therapy and behavior therapy for menopausal symptoms: a systematic review and meta-analysis

Published online by Cambridge University Press:  11 January 2022

Mengfei Ye Open the ORCID record for Mengfei Ye [Opens in a new window] ,
Mengna Shou ,
Jian Zhang ,
Baiqi Hu ,
Chunyan Liu ,
Chenchen Bi ,
Tingting Lv ,
Fangyi Luo ,
Zeying Zhang  and
Shenglin Liang
...Show all authors
Mengfei Ye
Affiliation:
Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang, China
Mengna Shou
Affiliation:
Departmentof Obstetrics and Gynecology, Shaoxing Women's and Children's Hospital, Shaoxing, Zhejiang, China
Jian Zhang
Affiliation:
Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang, China
Baiqi Hu
Affiliation:
Department of Neurology, Shaoxing Hospital, China Medical University, Shaoxing, Zhejiang, China
Chunyan Liu
Affiliation:
Department of Orthopedics, Shaoxing People's Hospital, The First Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China
Chenchen Bi
Affiliation:
Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang, China
Tingting Lv
Affiliation:
Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang, China
Fangyi Luo
Affiliation:
Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang, China
Zeying Zhang
Affiliation:
Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang, China
Shenglin Liang
Affiliation:
Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
Hong Feng
Affiliation:
Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
Chao Qian
Affiliation:
Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
Shilin Cao
Affiliation:
Department of Psychiatry, Shaoxing Seventh People's Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
Zheng Liu*
Affiliation:
Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang, China
*
Author for correspondence: Zheng Liu, E-mail: [email protected]
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Abstract

Background

T long-term effects of cognitive therapy and behavior therapy (CTBT) for menopausal symptoms are unknown, and whether the effects are different between natural menopause and treatment-induced menopause are currently unclear. Therefore, we sought to conduct an accurate estimate of the efficacy of CTBT for menopausal symptoms.

Methods

We conducted searches of Cochrane Library, EMBASE, PsycINFO, PubMed, and Web of Science databases for studies from 1 January 1977 to 1 November 2021. Randomized controlled trials (RCTs) comparing intervention groups to control groups for menopausal symptoms were included. Hedge's g was used as the standardized between-group effect size with a random-effects model.

Results

We included 14 RCTs comprising 1618 patients with a mean sample size of 116. CTBT significantly outperformed control groups in terms of reducing hot flushes [g = 0.39, 95% confidence interval (CI) 0.23–0.55, I2 = 45], night sweats, depression (g = 0.50, 95% CI 0.34–0.66, I2 = 51), anxiety (g = 0.38, 95% CI 0.23–0.54, I2 = 49), fatigue, and quality of life. Egger's test indicated no publication bias.

Conclusions

CTBT is an effective psychological treatment for menopausal symptoms, with predominantly small to moderate effects. The efficacy is sustained long-term, although it declines somewhat over time. The efficacy was stronger for natural menopause symptoms, such as vasomotor symptoms, than for treatment-induced menopause symptoms. These findings provide support for treatment guidelines recommending CTBT as a treatment option for menopausal symptoms.

Keywords

Anxietybehavior therapycognitive therapydepressionmenopausal symptomsmeta-analysis
Type
Review Article
Information
Psychological Medicine , Volume 52 , Issue 3 , February 2022 , pp. 433 - 445
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

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