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The effects of administering lithium carbonate on the balance of Na, K and water in manic-depressive patients

Published online by Cambridge University Press:  09 July 2009

Brij M. Saran  and
Gerald F. M. Russell
Brij M. Saran
Affiliation:
Metabolic Unit, Maudsley Hospital, London
Gerald F. M. Russell*
Affiliation:
Metabolic Unit, Maudsley Hospital, London
*
2Address for correspondence: Professor G. F. M. Russell, Royal Free Hospital, Pond Street, London
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Synopsis

Eleven patients in remission from manic-depressive illness were studied by means of metabolic balances before and after the administration of lithium carbonate. Lithium caused a sharp diuresis of isotonic saline and a smaller excretion of potassium over the course of two days. During the subsequent two days there occurred a compensatory retention of Na, K and water. These short-term changes were not associated with any significant alteration in the patients' mood. There was no significant and systematic retention of Na, K or water over the 14 days of Li administration. The recovery of Li was measured simultaneously. During the first week only a proportion of the administered Li was recovered in the urine and faeces, suggesting that a gradual distribution of Li throughout its body space was occurring. After the first week, nearly all the administered Li was recovered, indicating an equilibrium with an even distribution of the ion throughout its body space. This equilibrium was more complete at this early stage in those patients who had been given a smaller dose of lithium carbonate.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 3 , August 1976 , pp. 381 - 392
Copyright
Copyright © Cambridge University Press 1976

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