Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-24T20:41:46.818Z Has data issue: false hasContentIssue false
  • English
  • Français

Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals

Published online by Cambridge University Press:  11 October 2017

Dong-jie Xie ,
Simon S. Y. Lui ,
Fu-lei Geng ,
Zhuo-ya Yang ,
Ying-min Zou ,
Ying Li ,
Hera K. H. Yeung ,
Eric F. C. Cheung ,
Erin A. Heerey  and
Raymond C. K. Chan
Dong-jie Xie
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Simon S. Y. Lui
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China Castle Peak Hospital, Hong Kong Special Administrative Region, China
Fu-lei Geng
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China School of Psychology, South China Normal University, Guangzhou, China Center for Studies of Psychological Application, South China Normal University, Guangzhou, China
Zhuo-ya Yang
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Ying-min Zou
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Ying Li
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China Haidian District Mental Health Prevent-Treatment Hospital, Beijing, China
Hera K. H. Yeung
Affiliation:
Castle Peak Hospital, Hong Kong Special Administrative Region, China
Eric F. C. Cheung
Affiliation:
Castle Peak Hospital, Hong Kong Special Administrative Region, China
Erin A. Heerey
Affiliation:
Department of Psychology, Western University, London, Ontario, Canada
Raymond C. K. Chan*
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
*
Author for correspondence: Raymond C. K. Chan, E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

The neuropsychological origins of negative syndrome of schizophrenia remain elusive. Evidence from behavioural studies, which utilised emotion-inducing pictures to elicit motivated behaviour generally reported that that schizophrenia patients experienced similar affective experience as healthy individuals but failed to translate emotional salience to motivated behaviour, a phenomenon called emotion–behaviour decoupling. However, a few studies have examined emotion–behaviour decoupling in non-psychotic high-risk populations, who are relatively unaffected by medication effects.

Methods

In this study, we examined the nature and extent of emotion–behaviour decoupling in in three independent samples (65 schizophrenia patients v. 63 controls; 40 unaffected relatives v. 45 controls; and 32 individuals with social anhedonia v. 32 controls). We administered an experimental task to examine their affective experience and its coupling with behaviour, using emotion-inducing slides, and allowed participants to alter stimulus exposure using button-pressing to seek pleasure or avoid aversion.

Results

Schizophrenia patients reported similar affective experiences as their controls, while their unaffected relatives and individuals with high levels of social anhedonia exhibited attenuated affective experiences, in particular in the arousal aspect. Compared with their respective control groups, all of the three groups showed emotion–behaviour decoupling.

Conclusions

Our findings support that both genetically and behaviourally high-risk groups exhibit emotion–behaviour decoupling. The familial association apparently supports its role as a putative trait marker for schizophrenia.

Keywords

Anhedoniaavolitionemotion–behaviour decouplingschizophreniaschizotypyunaffected relatives.
Type
Original Articles
Information
Psychological Medicine , Volume 48 , Issue 9 , July 2018 , pp. 1474 - 1483
Copyright
Copyright © Cambridge University Press 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

†

These two authors contributed equally to the study.

References

Andreasen, NC (1989) The Scale for the Assessment of Negative Symptoms (SANS): conceptual and theoretical foundations. British Journal of Psychiatry 7, 49–58.CrossRefGoogle Scholar
Berridge, KC and Robinson, TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Research Reviews 28, 309–369.CrossRefGoogle ScholarPubMed
Chan, RCK et al. (2008) The development of a Chinese equivalence version of Letter-Number Span Test. Clinical Neuropsychologist 22, 112–121.CrossRefGoogle ScholarPubMed
Chan, RCK et al. (2010) Anticipatory and consummatory components of the experience of pleasure in schizophrenia: cross-cultural validation and extension. Psychiatry Research 175, 181–183.CrossRefGoogle ScholarPubMed
Chan, RCK et al. (2012) A study of trait anhedonia in non-clinical Chinese samples: evidence from the Chapman scales for physical and social anhedonia. PLoS One 7, e34275.Google ScholarPubMed
Chapman, LJ, Chapman, JP and Raulin, ML (1976) Scales for physical and social anhedonia. Journal of Abnormal Psychology 85, 374–382.CrossRefGoogle ScholarPubMed
Cohen, AS et al. (2012) On “risk” and reward: investigating state anhedonia in psychometrically defined schizotypy and schizophrenia. Journal of Abnormal Psychology 121, 407–415.CrossRefGoogle Scholar
Cohen, AS and Minor, KS (2010) Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies. Schizophrenia Bulletin 36, 143–150.CrossRefGoogle ScholarPubMed
Docherty, AR, Sponheim, SR and Kerns, JG (2015) Self-reported affective traits and current affective experiences of biological relatives of people with schizophrenia. Schizophrenia Research 161, 340–344.CrossRefGoogle ScholarPubMed
Eckblad, ML et al. (1982) The Revised Social Anhedonia Scale. Unpublished test. University of Wisconsin: Madison.Google Scholar
Fervaha, G et al. (2013) Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision making. Journal of Psychiatric Research 47, 1590–1596.CrossRefGoogle ScholarPubMed
First, MB et al. (1996) Structured Clinical Interview for DSM-IV (SCID-I) (User's Guide and Interview) Research Version. Biometrics Research Institute, New York State Psychiatric Institute: New York.Google Scholar
Gard, DE et al. (2006) Anticipatory and consummatory components of the experience of pleasure: a scale development study. Journal of Research in Personality 40, 1086–1102.CrossRefGoogle Scholar
Gard, DE et al. (2007) Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure. Schizophrenia Research 93, 253–260.CrossRefGoogle ScholarPubMed
Gard, DE et al. (2014) Do people with schizophrenia have difficulty anticipating pleasure, engaging in effortful behavior, or both? Journal of Abnormal Psychology 123, 771–782.CrossRefGoogle ScholarPubMed
Gold, JM et al. (1997) Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Archives in General Psychiatry 54, 159–165.CrossRefGoogle ScholarPubMed
Gold, JM et al. (2013) Negative symptoms of schizophrenia are associated with abnormal effort-cost computations. Biological Psychiatry 74, 130–136.CrossRefGoogle ScholarPubMed
Gold, JM et al. (2012) Negative symptoms and the failure to represent the expected reward value of actions. Archives of General Psychiatry 69, 129–138.CrossRefGoogle ScholarPubMed
Gold, JM et al. (2008) Reward processing in schizophrenia: a deficit in the representation of value. Schizophrenia Bulletin 34, 835–847.CrossRefGoogle ScholarPubMed
Gong, YX (1992) Manual of Wechsler Adult Intelligence Scale-Chinese Version. Chinese Map Press: Changsha.Google Scholar
Gooding, DC, Tallent, KA and Matts, CW (2005) Clinical status of at-risk individuals 5 years later: further validation of the psychometric high-risk strategy. Journal of Abnormal Psychology 114, 170–175.CrossRefGoogle ScholarPubMed
Gottesman, II and Gould, TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry 160, 636–645.CrossRefGoogle ScholarPubMed
Heerey, EA and Gold, JM (2007) Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior. Journal of Abnormal Psychology 116, 268–278.CrossRefGoogle ScholarPubMed
Kay, SR, Fiszbein, A and Opler, LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261–276.CrossRefGoogle ScholarPubMed
Kerns, JG, Docherty, AR and Martin, EA (2008) Social and physical anhedonia and valence and rrousal aspects of emotional experience. Journal of Abnormal Psychology 117, 735–746.CrossRefGoogle ScholarPubMed
Kring, AM and Barch, MB (2014) The motivation and pleasure dimension of negative symptoms: neural substrates and behavioral outputs. European Neuropsychopharmacology 24, 725–736.CrossRefGoogle ScholarPubMed
Kwapil, TR (1998) Social anhedonia as a predictor of the development of schizophrenia-spectrum disorders. Journal of Abnormal Psychology 107, 558–565.CrossRefGoogle ScholarPubMed
Kwapil, TR, Barrantes-Vidal, N and Silvia, PJ (2008) The dimensional structure of the Wisconsin schizotypy scales: factor identification and construct validity. Schizophrenia Bulletin 34, 444–457.CrossRefGoogle ScholarPubMed
Lenzenweger, MF (2015) Thinking clearly about schizotypy: hewing to the schizophrenia liability core, considering interesting tangents, and avoiding conceptual quicksand. Schizophrenia Bulletin 41(s2), s483-s491.CrossRefGoogle Scholar
Lui, SSY et al. (2016 a). The nature of anhedonia and avolition in patients with first-episode schizophrenia. Psychological Medicine 46, 437–447.CrossRefGoogle ScholarPubMed
Lui, SSY et al. (2016 b). Affective experience and motivated behavior in schizophrenia spectrum disorders: evidence from clinical and non-clinical samples. Neuropsychology 30, 673–684.CrossRefGoogle Scholar
Marder, SR, Rabinowitz, J and Kapur, S (2013) Clinical trials for negative symptoms – emerging directions and unresolved issues. Schizophrenia Research 150, 327–327.CrossRefGoogle ScholarPubMed
Mason, OJ (2015) The assessment of schizotypy and its clinical relevance. Schizophrenia Bulletin 41(s2), s374-s383.CrossRefGoogle ScholarPubMed
McCarthy, JM, Treadway, MT and Blanchard, JJ (2015) Motivation and effort in individuals with social anhedonia. Schizophrenia Research 165, 70–75.CrossRefGoogle ScholarPubMed
Meehl, PE (1962) Schizotaxia, schizotypy, schizophrenia. American Psychologist 17, 827–838.CrossRefGoogle Scholar
Meehl, PE (1989) Schizotaxia revisited. Archives of General Psychiatry 46, 935–944.CrossRefGoogle ScholarPubMed
Moritz, S et al. (2013) Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect? Neuropharmacology 72, 179–186.CrossRefGoogle ScholarPubMed
Raine, A (1991) The SPQ – a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin 17, 555–564.CrossRefGoogle ScholarPubMed
Reddy, LF et al. (2015) Effort-based decision making paradigms for clinical trials in schizophrenia: Part 1 – psychometric characteristics of 5 paradigms. Schizophrenia Bulletin 41, 1045–1054.CrossRefGoogle ScholarPubMed
Treadway, MT et al. (2015) Impaired effort allocation in patients with schizophrenia. Schizophrenia Research 161, 382–385.CrossRefGoogle ScholarPubMed
Ventura, J et al. (2015) Negative symptoms and functioning during the first year after a recent onset of schizophrenia and 8 years later. Schizophrenia Research 161, 407–413.CrossRefGoogle ScholarPubMed
Wang, J et al. (2015) Anhedonia in schizophrenia: deficits in both motivation and hedonic capacity. Schizophrenia Research 168, 465–474.CrossRefGoogle ScholarPubMed
Wang, K et al. (2016) Cross-cultural validation of the depression anxiety stress scale-21 in China. Psychological Assessment 28, 88–100.CrossRefGoogle ScholarPubMed
Supplementary material: File

Xie et al supplementary material

Xie et al supplementary material 1

Download Xie et al supplementary material(File)
File 28.7 KB