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The death(s) of close friends and family moderate genetic influences on symptoms of major depressive disorder in adolescents

Published online by Cambridge University Press:  01 July 2010

S. Gheyara ,
K. L. Klump ,
M. McGue ,
W. G. Iacono  and
S. A. Burt
S. Gheyara
Affiliation:
Department of Psychology, Michigan State University, East Lansing, MI, USA
K. L. Klump
Affiliation:
Department of Psychology, Michigan State University, East Lansing, MI, USA
M. McGue
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
W. G. Iacono
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
S. A. Burt*
Affiliation:
Department of Psychology, Michigan State University, East Lansing, MI, USA
*
*Address for correspondence: S. A. Burt, Ph.D., Department of Psychology, Michigan State University, Psychology Building, East Lansing, MI 48824, USA. (Email: [email protected])
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Abstract

Background

Prior work has suggested that genetic influences on major depressive disorder (MDD) may be activated by the experience of negative life events. However, it is unclear whether these results persist when controlling for the possibility of confounding active gene–environment correlations (rGE).

Method

We examined a sample of 1230 adopted and biological siblings between the ages of 10 and 20 years from the Sibling Interaction and Behavior Study. MDD was measured via a lifetime DSM-IV symptom count. Number of deaths experienced served as our environmental risk experience. Because this variable is largely independent of the individual's choices/behaviors, we were able to examine gene–environment interactions while circumventing possible rGE confounds.

Results

Biometric analyses revealed pronounced linear increases in the magnitude of genetic influences on symptoms of MDD with the number of deaths experienced, such that genetic influences were estimated to be near-zero for those who had experienced no deaths but were quite large in those who had experienced two or more deaths (i.e. accounting for roughly two-thirds of the phenotypic variance). By contrast, shared and non-shared environmental influences on symptoms of MDD were not meaningfully moderated by the number of deaths experienced.

Conclusions

Such results constructively replicate prior findings of genetic moderation of depressive symptoms by negative life events, thereby suggesting that this effect is not a function of active rGE confounds. Our findings are thus consistent with the notion that exposure to specific negative life events may serve to activate genetic risk for depression during adolescence.

Keywords

Adoption studiesdeathdepressiongene–environment interactionsgenetic influences
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 4 , April 2011 , pp. 721 - 729
Copyright
Copyright © Cambridge University Press 2010

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References

Achenbach, TM, McConaughy, SH, Howell, CT (1987). Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. Psychological Bulletin 101, 213–232.Google Scholar
Bemmels, HR, Burt, SA, Legrand, LN, Iacono, WG, McGue, M (2008). The heritability of life events: an adolescent twins and adoption study. Twin Research and Human Genetics 11, 257–265.CrossRefGoogle ScholarPubMed
Billig, JP, Hershberger, SL, Iacono, WG, McGue, M (1996). Life events and personality in late adolescence: genetic and environmental relations. Behavioral Genetics 26, 543–554.CrossRefGoogle ScholarPubMed
Brown, GW, Harris, DO (1978). Social Origins of Depression: A Study of Psychiatric Disorder in Women. Tavistock: London.Google Scholar
Burt, SA (2009). Rethinking environmental contributions to child and adolescent psychopathology: a meta-analysis of shared environmental influences. Psychological Bulletin 135, 608–637.CrossRefGoogle ScholarPubMed
Caspi, A, Sugden, K, Moffitt, TE, Taylor, A, Craig, IW, Harrington, H, McClay, J, Mill, J, Martin, J, Braithwaite, A, Poulton, R (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386–389.CrossRefGoogle ScholarPubMed
Eaves, L, Silberg, J, Erkanli, A (2003). Resolving multiple epigenetic pathways to adolescent depression. Journal of Child Psychology and Psychiatry 44, 1006–1014.CrossRefGoogle ScholarPubMed
Ge, X, Conger, RD, Elder, GHJ (2001). Pubertal transition, stressful life events, and the emergence of gender differences in adolescent depressive symptoms. Development and Psychopathology 37, 404–417.Google ScholarPubMed
Gillespie, NA, Whitfield, JB, Williams, B, Heath, AC, Martin, NG (2005). The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychological Medicine 35, 101–111.CrossRefGoogle ScholarPubMed
Goodyer, I, Herbert, J, Tamplin, A, Altham, PME (2000). Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents. British Journal of Psychiatry 177, 499–504.Google Scholar
Harrison, L, Harrington, R (2001). Adolescents' bereavement experiences. Prevalence, association with depressive symptoms, and use of services. Journal of Adolescence 24, 159–169.CrossRefGoogle ScholarPubMed
Hicks, B, DiRago, A, Iacono, W, McGue, M (2009). Gene–environment interplay in internalizing disorders: consistent findings across six environmental risk factors. Journal of Child Psychology and Psychiatry 50, 1309–1317.CrossRefGoogle ScholarPubMed
Jacobs, N, Kenis, G, Peeters, F, Derom, C, Vlietinck, R, van Os, J (2006). Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Archives of General Psychiatry 63, 989–996.Google Scholar
Kendler, KS, Karkowski, LM, Prescott, CA (1998). Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity. Journal of Nervous and Mental Disease 186, 661–669.CrossRefGoogle ScholarPubMed
Kendler, KS, Karkowski, LM, Prescott, CA (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry 156, 837–841.CrossRefGoogle ScholarPubMed
Kendler, KS, Karkowski-Shuman, L (1997). Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? Psychological Medicine 27, 539–547.CrossRefGoogle ScholarPubMed
Kendler, KS, Kuhn, JW, Vittum, J, Prescott, CA, Riley, B (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression. Archives of General Psychiatry 62, 529–535.CrossRefGoogle Scholar
Kendler, KS, Thornton, LM, Gardner, CO (2001). Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. American Journal of Psychiatry 158, 582–586.CrossRefGoogle ScholarPubMed
Kim, JM, Stewart, R, Kim, SW, Yang, SJ, Shin, IS, Kim, YH, Yoon, JS (2007). Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biological Psychiatry 62, 423–428.Google Scholar
Lau, J, Eley, T (2008). Disentangling gene environment correlations and interactions in adolescent depression. Journal of Child Psychology and Psychiatry 49, 142–150.CrossRefGoogle Scholar
McGue, M, Bouchard, TJ Jr. (1984). Adjustment of twin data for the effects of age and sex. Behavioral Genetics 14, 325–343.Google Scholar
McGue, M, Keyes, M, Sharma, A, Elkins, I, Legrand, L, Johnson, W, Iacono, WG (2007). The environments of adopted and non-adopted youth: evidence on range restriction from the Sibling Interaction and Behavior Study (SIBS). Behavioral Genetics 37, 449–462.Google Scholar
Moffitt, TE, Caspi, A, Rutter, M (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry 62, 473–481.CrossRefGoogle ScholarPubMed
Neale, MC, Boker, SM, Xie, G, Maes, HH (2003). Mx: Statistical Modeling, 6th edn. Virginia Commonwealth University: Richmond, VA.Google Scholar
Plomin, R, DeFries, JC, McClearn, GE, McGruffin, P (2008). Behavioral Genetics, revised 5th edn. Worth Publishers: New York.Google Scholar
Purcell, S (2002). Variance components models for gene–environment interaction in twin analysis. Twin Research 5, 554–571.Google Scholar
Risch, N, Herrell, R, Lehner, T, Liang, KY, Eaves, L, Hoh, J, Griem, A, Kovacs, M, Ott, J, Merikangas, KR (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA: Journal of the American Medical Association 301, 2462–2471.Google Scholar
Rudolph, KD, Hammen, C (1999). Age and gender as determinants of stress exposure, generation, and reactions in youngsters: a transactional perspective. Child Development 70, 660–677.Google Scholar
Silberg, J, Pickles, A, Rutter, M, Hewitt, J, Simonoff, E, Maes, H, Carbonneau, R, Murrelle, L, Foley, D, Eaves, L (1999). The influence of genetic factors and life stress on depression among adolescent girls. Archives of General Psychiatry 56, 225–232.CrossRefGoogle ScholarPubMed
Silberg, J, Rutter, M, Neale, M, Eaves, L (2001). Genetic moderation of environmental risk for depression and anxiety in adolescent girls. British Journal of Psychiatry 179, 116–121.Google Scholar
Stoolmiller, M (1998). Correcting estimates of shared environmental variance for range restriction in adoption studies using a truncated multivariate normal model. Behavioral Genetics 28, 429–441.CrossRefGoogle ScholarPubMed
Sullivan, PF, Neale, MC, Kendler, KS (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry 157, 1552–1562.Google Scholar
Surtees, PG, Wainwright, NW, Willis-Owen, SA, Luben, R, Day, NE, Flint, J (2006). Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biological Psychiatry 59, 224–229.CrossRefGoogle ScholarPubMed
Tully, EC, Iacono, WG, McGue, M (2008). An adoption study of parental depression as an environmental liability for adolescent depression and childhood disruptive disorders. American Journal of Psychiatry 165, 1148–1154.CrossRefGoogle ScholarPubMed
Welner, Z, Reich, W, Herjanic, B, Jung, KG, Amado, H (1987). Reliability, validity, and parent–child agreement studies of the Diagnostic Interview for Children and Adolescents (DICA). Journal of the American Academy of Child and Adolescent Psychiatry 26, 649–653.CrossRefGoogle ScholarPubMed
Williamson, D, Birmaher, B, Anderson, B, Al-Shabbout, M, Ryan, N (1995). Stressful life events in depressed adolescents: the role of dependent events during the depressive episode. Journal of the American Academy of Child and Adolescent Psychiatry 34, 591–598.Google Scholar