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Changes in serum tryptophan and albumin binding of tryptophan in chlorpromazine-treated chronic schizophrenics on withdrawal and restoration of drug therapy

Published online by Cambridge University Press:  09 July 2009

D. A. Bender ,
R. M. Pigache ,
J. Gruzelier  and
N. Hammond
D. A. Bender*
Affiliation:
From the Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, the Joint Neuropsychology Research Unit, Friern Hospital, London, and the Department of Clinical Pharmacology, University College Hospital Medical School, London
R. M. Pigache
Affiliation:
From the Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, the Joint Neuropsychology Research Unit, Friern Hospital, London, and the Department of Clinical Pharmacology, University College Hospital Medical School, London
J. Gruzelier
Affiliation:
From the Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, the Joint Neuropsychology Research Unit, Friern Hospital, London, and the Department of Clinical Pharmacology, University College Hospital Medical School, London
N. Hammond
Affiliation:
From the Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, the Joint Neuropsychology Research Unit, Friern Hospital, London, and the Department of Clinical Pharmacology, University College Hospital Medical School, London
*
1Address for correspondence: Dr. D. A. Bender, Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London Wl P 5PR.
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Synopsis

Withdrawal of drug from a group of chlorpromazine-treated chronic male schizophrenics led to a significant rise in the initially low serum tryptophan concentration, and a rise in the fraction freely diffusible. These changes, which would be expected to lead to an increase in tryptophan influx into the brain, and hence to an increase in cerebral serotonin synthesis, could be related to the clinical effects of drug withdrawal.

Type
Original Article
Information
Psychological Medicine , Volume 5 , Issue 4 , November 1975 , pp. 397 - 403
Copyright
Copyright © Cambridge University Press 1975

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References

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