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Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study

Published online by Cambridge University Press:  15 July 2015

K. L. Klump ,
B. A. Hildebrandt ,
S. M. O'Connor ,
P. K. Keel ,
M. Neale ,
C. L. Sisk ,
S. Boker  and
S. A. Burt
K. L. Klump*
Affiliation:
Department of Psychology, Michigan State University, East Lansing, MI, USA
B. A. Hildebrandt
Affiliation:
Department of Psychology, Michigan State University, East Lansing, MI, USA
S. M. O'Connor
Affiliation:
Department of Psychology, Michigan State University, East Lansing, MI, USA
P. K. Keel
Affiliation:
Department of Psychology, Florida State University, Tallahassee, FL, USA
M. Neale
Affiliation:
Departments of Psychiatry, Human Genetics, and Psychology, Virginia Commonwealth University, Charlottesville, VA, USA
C. L. Sisk
Affiliation:
Department of Psychology, Michigan State University, East Lansing, MI, USA Neuroscience Program, Michigan State University, East Lansing, MI, USA
S. Boker
Affiliation:
Department of Psychology, University of Virginia, Richmond, VA, USA
S. A. Burt
Affiliation:
Department of Psychology, Michigan State University, East Lansing, MI, USA
*
* Address for correspondence: K. L. Klump, Ph.D., Department of Psychology, Michigan State University, 316 Physics Road – Room 107B Psychology, East Lansing, MI 48824-1116, USA. (Email: [email protected])
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Abstract

Background

Previous studies have shown significant within-person changes in binge eating and emotional eating across the menstrual cycle, with substantial increases in both phenotypes during post-ovulation. Increases in both estradiol and progesterone levels appear to account for these changes in phenotypic risk, possibly via increases in genetic effects. However, to date, no study has examined changes in genetic risk for binge phenotypes (or any other phenotype) across the menstrual cycle. The goal of the present study was to examine within-person changes in genetic risk for emotional eating scores across the menstrual cycle.

Method

Participants were 230 female twin pairs (460 twins) from the Michigan State University Twin Registry who completed daily measures of emotional eating for 45 consecutive days. Menstrual cycle phase was coded based on dates of menstrual bleeding and daily ovarian hormone levels.

Results

Findings revealed important shifts in genetic and environmental influences, where estimates of genetic influences were two times higher in post- as compared with pre-ovulation. Surprisingly, pre-ovulation was marked by a predominance of environmental influences, including shared environmental effects which have not been previously detected for binge eating phenotypes in adulthood.

Conclusions

Our study was the first to examine within-person shifts in genetic and environmental influences on a behavioral phenotype across the menstrual cycle. Results highlight a potentially critical role for these shifts in risk for emotional eating across the menstrual cycle and underscore the need for additional, large-scale studies to identify the genetic and environmental factors contributing to menstrual cycle effects.

Keywords

Emotional eatingenvironmental influencesgenetic influencesmenstrual cycleovarian hormones
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 15 , November 2015 , pp. 3227 - 3237
Copyright
Copyright © Cambridge University Press 2015 

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References

Akaike, H (1987). Factor analysis and AIC. Psychometrika 52, 317–332.CrossRefGoogle Scholar
Asarian, L, Geary, N (2006). Modulation of appetite by gonadal steroid hormones. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 361, 1251–1263.CrossRefGoogle ScholarPubMed
Asarian, L, Geary, N (2013). Sex differences in the physiology of eating. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 305, R1215–R1267.Google ScholarPubMed
Becker, JB (1999). Gender differences in dopaminergic function in striatum and nucleus accumbens. Pharmacology, Biochemistry and Behavior 64, 803–812.Google Scholar
Boker, SM, Neale, MC, Klump, KL (2014). A differential equations model for the ovarian hormone cycle. In Handbook of Relational Developmental Systems: Emerging Methods and Concepts (ed. Molenaar, P.C., Lerner, R. and Newell, K.). John Wiley & Sons: New York.Google Scholar
Bulik, CM, Sullivan, PF, Kendler, KS (1998). Heritability of binge-eating and broadly defined bulimia nervosa. Biological Psychiatry 44, 1210–1218.CrossRefGoogle ScholarPubMed
Bulik, CM, Sullivan, PF, Wade, TD, Kendler, KS (2000). Twin studies of eating disorders: a review. International Journal of Eating Disorders 17, 251–261.3.0.CO;2-V>CrossRefGoogle Scholar
Burt, SA, Klump, KL (2013). The Michigan State University Twin Registry (MSUTR): an update. Twin Research and Human Genetics 16, 344–350.CrossRefGoogle ScholarPubMed
Deaver, CM, Miltenberger, RG, Symth, J, Meidinger, A, Crosby, R (2003). An evaluation of affect and binge eating. Behavior Modification 27, 578–599.CrossRefGoogle ScholarPubMed
Edler, C, Lipson, SF, Keel, PK (2007). Ovarian hormones and binge eating in bulimia nervosa. Psychological Medicine 37, 131–141.CrossRefGoogle ScholarPubMed
Fairburn, CG (2008). Cognitive Behavior Therapy and Eating Disorders. Guilford Press: New York.Google ScholarPubMed
Graves, NS, Hayes, H, Fan, L, Curtis, KS (2011). Time course of behavioral, physiological, and morphological changes after estradiol treatment of ovariectomized rats. Physiology and Behavior 103, 261–267.CrossRefGoogle ScholarPubMed
Hildebrandt, BA, Racine, SE, Keel, PK, Burt, SA, Neale, M, Boker, S, Sisk, CL, Klump, KL (2014). The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle. International Journal of Eating Disorders 48, 477–486.CrossRefGoogle ScholarPubMed
Hildebrandt, T, Alfano, L, Tricamo, M, Pfaff, DW (2010). Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa. Clinical Psychology Review 30, 655–668.Google Scholar
Klump, KL (2013). Puberty as a critical risk period for eating disorders: a review of human and animal studies. Hormones and Behavior 64, 399–410.Google Scholar
Klump, KL, Burt, SA (2006). The Michigan State University Twin Registry (MSUTR): genetic, environmental and neurobiological influences on behavior across development. Twin Research and Human Genetics 9, 971–977.Google Scholar
Klump, KL, Burt, SA, McGue, M, Iacono, WG (2007). Changes in genetic and environmental influences on disordered eating across adolescence: a longitudinal twin study. Archives of General Psychiatry 64, 1409–1415.Google Scholar
Klump, KL, Burt, SA, McGue, M, Iacono, WG, Wade, TM (2010 a). Age differences in genetic and environmental influences on weight and shape concerns. International Journal of Eating Disorders 43, 679–688.Google Scholar
Klump, KL, Keel, PK, Burt, SA, Racine, SE, Neale, MC, Sisk, CL, Boker, S (2013 a). Ovarian hormones and emotional eating across the menstrual cycle: an examination of the potential moderating effects of body mass index and dietary restraint. International Journal of Eating Disorders 46, 256–263.CrossRefGoogle ScholarPubMed
Klump, KL, Keel, PK, Culbert, KM, Edler, C (2008). Ovarian hormones and binge eating: exploring associations in community samples. Psychological Medicine 38, 1749–1757.CrossRefGoogle ScholarPubMed
Klump, KL, Keel, PK, Racine, SE, Burt, SA, Neale, M, Sisk, CL, Boker, S, Hu, JY (2013 b). The interactive effects of estrogen and progesterone on changes in emotional eating across the menstrual cycle. Journal of Abnormal Psychology 122, 131–137.CrossRefGoogle ScholarPubMed
Klump, KL, Keel, PK, Sisk, CL, Burt, SA (2010 b). Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychological Medicine 40, 1745–1753.Google Scholar
Klump, KL, McGue, M, Iacono, WG (2000). Age differences in genetic and environmental influences on eating attitudes and behaviors in female adolescent twins. Journal of Abnormal Psychology 109, 239–251.Google Scholar
Klump, KL, McGue, M, Iacono, WG (2003). Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins. International Journal of Eating Disorders 33, 287–292.CrossRefGoogle ScholarPubMed
Klump, KL, Racine, SE, Hildebrandt, B, Burt, SA, Neale, M, Sisk, CL, Boker, S, Keel, PK (2014). Ovarian hormone influences on dysregulated eating: a comparison of associations in women with versus without binge episodes. Clinical Psychological Science 2, 545–559.Google Scholar
Laghi, F, Pompili, S, Baumgartner, E, Baiocco, R (2015). The role of sensation seeking and motivations for eating in female and male adolescents who binge eat. Eating Behaviors 17, 119–124.Google Scholar
Lester, NA, Keel, PK, Lipson, SF (2003). Symptom fluctuation in bulimia nervosa: relation to menstrual-cycle phase and cortisol levels. Psychological Medicine 33, 51–60.Google Scholar
Lluch, A, Herbert, B, Mejean, L, Siest, G (2000). Dietary intakes, eating style and overweight in Stanilas Family Study. International Journal of Obesity 24, 1493–1499.CrossRefGoogle ScholarPubMed
Logan, PC, Ponnampalam, AP, Steiner, M, Mitchell, MD (2012). Effect of cyclic AMP and estrogen/progesterone on the transcription of DNA methyltransferases during the decidualization of human endometrial stromal cells. Molecular Human Reproduction 19, 302–312.Google Scholar
Martin, MG, Eaves, LJ, Kearsey, MJ, Davies, P (1978). The power of the classical twin study. Heredity 40, 97–116.Google Scholar
McManus, F, Waller, GI (1995). A functional analysis of binge-eating. Clinical Psychology Review 15, 845–863.CrossRefGoogle Scholar
Neale, MC, Boker, SM, Xie, G, Maes, HH (2003). Mx: Statistical Modeling. Department of Psychiatry: Richmond, VA.Google Scholar
Nguyen-Michel, ST, Unger, JB, Spruijt-Metz, D (2007). Dietary correlates of emotional eating in adolescence. Appetite 49, 494–499.Google Scholar
Ostlund, H, Keller, E, Hurd, YL (2003). Estrogen receptor gene expression in relation to neuropsychiatric disorders. Annals of the New York Academy of Sciences 1007, 54–63.Google Scholar
Purcell, S (2002). Variance components models for gene–environment interaction in twin analysis. Twin Research 5, 554–571.Google Scholar
Racine, SE, Culbert, KM, Larson, CL, Klump, KL (2009). The possible influences of impulsivity and dietary restraint on associations between serotonin genes and binge eating. Journal of Psychiatric Research 43, 1278–1286.Google Scholar
Racine, SE, Keel, PK, Burt, SA, Sisk, CL, Neale, M, Boker, S, Klump, KL (2013). Exploring the relationship between negative urgency and dysregulated eating: etiologic associations and the role of negative affect. Journal of Abnormal Psychology 122, 433–444.Google Scholar
Roepke, TA (2009). Oestrogen modulates hypothalamic control of energy homeostasis through multiple mechanisms. Journal of Neuroendocrinology 21, 141–150.Google Scholar
Roepke, TA, Qiu, J, Bosch, MA, Ronnekleiv, OK, Kelly, MJ (2009). Cross-talk between membrane-initiated and nuclear-initiated oestrogen signalling in the hypothalamus. Journal of Neuroendocrinology 21, 263–270.Google Scholar
Romeo, RD (2003). Puberty: a period of both organizational and activational effects of steroid hormones on neurobehavioural development. Journal of Neuroendocrinology 15, 1185–1192.Google Scholar
Santollo, J, Marshall, A, Daniels, D (2012). Activation of membrane associated estrogen receptors decreases food and water intake in ovariectomized rats. Endocrinology 154, 320–329.Google Scholar
Scherag, S, Hebebrand, J, Hinney, A (2010). Eating disorders: the current status of molecular genetic research. European Child and Adolescent Psychiatry 19, 211–226.Google Scholar
Schwarz, GE (1978). Estimating the dimension of a model. Annals of Statistics 6, 461–464.CrossRefGoogle Scholar
Schwarz, JM, Nugent, BM, McCarthy, MM (2010). Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span. Endocrinology 151, 4871–4881.Google Scholar
Sisk, CL, Zehr, JL (2005). Puberty hormones organize the adolescent brain and behavior. Frontiers in Neuroendocrinology 26, 163–174.Google Scholar
Snoek, HM, van Strien, T, Janssens, JM, Engels, RC (2007). Emotional, external, restrained eating and overweight in Dutch adolescents. Scandinavian Journal of Psychology 48, 23–32.Google Scholar
Sullivan, PF, Bulik, CR, Kendler, K (1998). Genetic epidemiology of binging and vomiting. British Journal of Psychiatry 173, 75–79.Google Scholar
Van Strien, T (2000). Ice-cream consumption, tendency toward overeating, and personality. Appetite 52, 380–387.Google Scholar
Van Strien, T, Frijters, JE, Bergers, GP, Defares, PB (1986). The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior. International Journal of Eating Disorders 5, 295–315.Google Scholar
Van Strien, T, Snoek, HM, van der Zwaluw, CS, Engles, RCME (2010). Parental control and the dopamine D2 receptor gene (DRD2) interaction on emotional eating in adolescence. Appetite 54, 255–261.CrossRefGoogle ScholarPubMed
Wade, TD, Gordon, S, Medland, S, Bulik, CM, Heath, AC, Montgomery, GW, Martin, NG (2013). Genetic variants associated with disordered eating. International Journal of Eating Disorders 46, 594–608.Google Scholar
Wardle, J (1987). Eating style: a validation study of the Dutch Eating Behaviour Questionnaire in normal subjects and women with eating disorders. Journal of Psychosomatic Research 31, 161–169.CrossRefGoogle Scholar
Wilson, JD, Foster, DW, Kronenberg, HM, Larsen, PR (1998). Williams Textbook of Endocrinology, 9th edn. W.B. Saunders Company: Philadelphia, PA.Google Scholar