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The acute and chronic effects of (+) and (−) oxaprotiline upon melatonin secretion in normal subjects

Published online by Cambridge University Press:  09 July 2009

E. Palazidou ,
D. Skene ,
J. Arendt ,
B. Everitt  and
S. A. Checkley
E. Palazidou*
Affiliation:
Institute of Psychiatry, London; Department of Biochemistry, University of Surrey, Guildford
D. Skene
Affiliation:
Institute of Psychiatry, London; Department of Biochemistry, University of Surrey, Guildford
J. Arendt
Affiliation:
Institute of Psychiatry, London; Department of Biochemistry, University of Surrey, Guildford
B. Everitt
Affiliation:
Institute of Psychiatry, London; Department of Biochemistry, University of Surrey, Guildford
S. A. Checkley
Affiliation:
Institute of Psychiatry, London; Department of Biochemistry, University of Surrey, Guildford
*
1 Address for correspondence: Dr E. Palazidou, Institute of Psychiatry, De Crespigny Park, London SE5 8AF.
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Synopsis

Ten healthy male subjects were treated for three weeks with (+)oxaprotiline, a selective inhibitor of noradrenaline (NA) uptake and with (−)oxaprotiline which does not inhibit NA uptake. Plasma melatonin concentrations were measured throughout the night at 0, 1, 7 and 21 days and were higher during treatment with (+)oxaprotiline than with (−)oxaprotiline for the entire three weeks of treatment. Since NA stimulates the production and secretion of melatonin, these results are consistent with a sustained increase in noradrenergic activity within the pineal, during 21 days of treatment with an effective NA uptake inhibitor.

Type
Original Articles
Information
Psychological Medicine , Volume 22 , Issue 1 , February 1992 , pp. 61 - 67
Copyright
Copyright © Cambridge University Press 1992

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