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L'ocytocine dans le traitement du trouble obsessionnel: un rapport négatif à propos de deux cas

Published online by Cambridge University Press:  28 April 2020

G. Charles ,
R. Guillaume ,
M. Schittecatte ,
P. Pholien ,
J.P. Van Wettere  and
J. Wilmotte
G. Charles
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
R. Guillaume
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
M. Schittecatte
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
P. Pholien
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
J.P. Van Wettere
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
J. Wilmotte
Affiliation:
Hôpital Vincent Van Gogh, rue de l'hôpital, 55, B-6030 Marchienne-au-Pont, Belgique
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Résumé

Deux patients, un homme de 43 ans et une femme de 24 ans, répondant aux critères diagnostiques du trouble obsessionnel compulsif ont été traités par ocytocine à 10 UI/jour, en intramusculaire. L'ocytocine est un nona-peptide hypophysaire dont la propriété d'altérer la mémoire est connue chez l'animal et chez l'homme. Une rémission relative du trouble obsessionnel compulsif a récemment été signalée lors d'un traitement prolongé par ocytocine intranasale. Nous n'avons, quant à nous, observé aucune amélioration des symptômes obsessionnels compulsifs (évalués selon la liste du Maudsley Hospital) durant les 15 à 20 jours de traitement. Les implications liées au mode d'administration sont discutées, de même que le rôle joué par d'éventuelles manifestations psychopathologiques survenant en cours de traitement.

Summary

Summary

Oxytocin is known to alter memory functions in both man and animal recently, clinical improvement of an obsessive-compulsive patient under ocytocine has been reported. Two inpatients, a 24-year-old female and a 43-year-old male suffering from obsessive-compulsive disorder, were treated with oxytocin IM (10 UI/day) during 2 years and 3 weeks, respectively. We did not observe any symptomatic improvement. Symptoms were assessed according to the Maudsley Inventory. Influences of pharmacokinetic parameters of the peptide and of preexistant psychopathology are discussed.

Keywords

troubles obsessionnels-compulsifsocytocineaction négativeobsessive-compulsive disorderoxytocinnegative report
Type
Fait clinique
Information
Psychiatry and Psychobiology , Volume 4 , Issue 2 , 1989 , pp. 111 - 115
Copyright
Copyright © European Psychiatric Association 1989

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References

Références

Ang, V.T.Y. & Jenkins, J.S. (1982) Blood-cerebrospinal fluid barrier to arginine-vasopressin, desmopressin desglycinamide arginine-vasopressin in the dog. J. Endocrinol. 93, 319–325CrossRefGoogle ScholarPubMed
Ansseau, M.Legros, J.J.Mormont, GCerfontaine, J.L.Papart, P.Geenen, V.Adam, F. & Franck, G. (1987) Intranasal oxytocin in obsessive-compulsive disorder. Psychoneuroendocrinology 12, 231–236CrossRefGoogle ScholarPubMed
Chapman, L.J. (1979) Recent advances in the study of schizophrenic cognition. Schizophr. Bull. V, 4, 568–580CrossRefGoogle Scholar
Charles, G. & Ansseau, M. (1987) Guide pour le diagnostic des troubles affectifs et de la schizophrénie. Acta Psychiatr. Belg. 87, 361–516Google Scholar
Fehm-Wolfsdorf, G.Bachholz, G.Born, J.Voigt, K. & Fehm, H.L. (1988) Vasopressin but not oxytocin enhances cortical arousal : an integrative hypothesis on behavioral effects of neurohypophyseal hormones. Psychopharmacology 94, 496–500CrossRefGoogle Scholar
Fehm-Wolfsdorf, G.Voigt, K.H. & Fehm, H.L. (1984) Human memory and neurohypophyseal hormones: opposite effects of vasopressin and oxytocin. Psychoneuroendocrinology 9, 285–292CrossRefGoogle ScholarPubMed
Ferrier, B.M.Kennett, D.J. & Devlin, M.C. (1980) Influence of oxytocin on human memory processes. Life Sci. 27, 2311–2317CrossRefGoogle ScholarPubMed
Fink, M. (1979) Convulsive Therapy: Theory and Practice. Raven Press, New YorkGoogle Scholar
Hamilton, M. (I960) A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23, 56–62CrossRefGoogle Scholar
Insel, T.R. (1984) New Findings in Obsessive-Compulsive Disorder. American Psychiatric Press, WashingtonGoogle Scholar
Kovacs, O.L. & Telegdy, I. (1982) Role of oxytocin in memory and amnesia. Pharmacol. Ther. 18, 375–395CrossRefGoogle ScholarPubMed
Landgraf, R. (1985) Plasma oxytocin concentrations in man after different routes of administration of synthetic oxytocin. Exp. Clin. Endocrinol. 85, 245–248CrossRefGoogle ScholarPubMed
Marks, I.M.Hallam, R.S. & Phellepot, R. (1987) Nursing in Behavioral Psychotherapy: Research Series of the Royal College of Nursing, Royal College of Nursing, LondonGoogle Scholar
Mellman, L.A. & Gorman, J.M. (1984) Successful treatment of obsessive compulsive disorder with ECT. Am. J. Psychiatry 141, 596–597Google ScholarPubMed
Norman, A.W. & Litwack, G. (1987) Hormones. Academic Press, OrlandoGoogle ScholarPubMed
Salzman, L. & Thaler, F.M. (1981) Obsessive-compulsive disorders: a review. Am. J. Psychiatry 138, 286–296Google ScholarPubMed
Schultz, H.Kovacs, G.L. & Telegdy, G. (1976) The effect of vasopressin and oxytocin on avoidance behavior in rats. In: Cellular and Molecular Bases of Neuroenocrine process, (Endoczy, E., ed) Akademiai Kiado, Budapest, p. 555–564Google Scholar
Taylor, J.L. & Tinklenberg, J.R. (1987) Cognitive impairment and benzodiazepines. In: Psychopharmacology (Meltzer, H.Y., ed.) Raven Press, New York, p. 1449Google Scholar
Zohar, J. & Insel, T.R. (1987) Drug treatment of obsessive-compulsive disorder: J. Affective Dis. 13, 193–202CrossRefGoogle Scholar
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