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Hyponatrémie induite par la carbamazépine et affection rénale: à propos d’un cas

Published online by Cambridge University Press:  28 April 2020

W. Pitchot ,
M. Ansseau ,
P. Papart ,
G. Franck  and
G. Rorive
W. Pitchot
Affiliation:
Unité de psychiatrie, Centre hospitalier universitaire de Liège, Domaine universitaire du Sart-Tilman (B35), B-4000 Liège 1, Belgique
M. Ansseau
Affiliation:
Unité de psychiatrie, Centre hospitalier universitaire de Liège, Domaine universitaire du Sart-Tilman (B35), B-4000 Liège 1, Belgique
P. Papart
Affiliation:
Unité de psychiatrie, Centre hospitalier universitaire de Liège, Domaine universitaire du Sart-Tilman (B35), B-4000 Liège 1, Belgique
G. Franck
Affiliation:
Unité de psychiatrie, Centre hospitalier universitaire de Liège, Domaine universitaire du Sart-Tilman (B35), B-4000 Liège 1, Belgique
G. Rorive
Affiliation:
Unité de néphrologie, Centre hospitalier universitaire de Liège, Domaine universitaire du Sart-Tilman (B35), B-4000 Liège 1, Belgique
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Résumé

L‘hyponatrémie constitue un effet secondaire rare de la carbamazépine, qui possède une action antidiurétique dont le mécanisme reste controversé. L‘existence avant le traitement d’un taux de sodium à la limite inférieure de la normale et l’association aux diurétiques semblent constituer des facteurs de risque prédisposant à l’hyponatrémie. Nous présentons le cas d’une patiente bipolaire, porteuse d’un rein unique, qui a développé une hyponatrémie après 5 jours de traitement par carbamazépine. Nous suggérons le rôle favorisant joué par la pathologie rénale dans le déclenchement de l’hyponatrémie.

Summary

Summary

Hyponatremia represents a rare side-effect of carbamazepine, which exhibits an antidiuretic activity of controversial pathophysiology. The presence before treatment of a sodium level in the tower range and the association with diuretics seem to represent factors increasing the risk for hyponatremia. We presented the case of a bipolar female patient with a single kidney who developed hyponatremia after 5 days of treatment by carbamazepine. We suggest a predisposing role of the renal pathology in the appearance of hyponatremia.

Keywords

carbamazépinehyponatrémieaffection rénalecarbamazepinehyponatremiarenal disorder
Type
Fait clinique
Information
Psychiatry and Psychobiology , Volume 4 , Issue 4 , 1989 , pp. 235 - 237
Copyright
Copyright © European Psychiatric Association 1989

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References

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