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Investigation of depot neuroleptic injection site reactions

Published online by Cambridge University Press:  02 January 2018

Julie C. Jones ,
Jennifer C. Day ,
John R. Taylor  and
Christopher S. Thomas
Julie C. Jones
Affiliation:
Department of Psychiatry, University Hospital of South Manchester, Manchester
Jennifer C. Day
Affiliation:
Department of Pharmaceutical Sciences, University of Nottingham, Nottingham
John R. Taylor
Affiliation:
North Mersey Community Trust, Sefton General Hospital, Liverpool
Christopher S. Thomas*
Affiliation:
Department of Psychiatry, University Hospital of South Manchester, Nell Lane, Manchester M20 8LR
*
∗Correspondence
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Abstract

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Aims and method

A cross-sectional survey was performed on 318 patients receiving depot medication. The presence or absence of a depot site reaction was recorded by psychiatric nursing staff on a standardised form.

Results

Seventeen per cent of patients were found to have clinically significant depot site reactions. Such reactions were associated with increased frequency of injection and increased total volume of depot administered in the previous 12 months. The severity of a depot site reaction was unrelated to the concentration of depot preparation administered.

Clinical implications

Depot site reactions may be reduced by maximising the interval between injections and using low volume (highly concentrated) preparations of depot neuroleptic medication.

Type
Original Papers
Information
Psychiatric Bulletin , Volume 22 , Issue 10 , October 1998 , pp. 605 - 607
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © 1998 The Royal College of Psychiatrists

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