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Some Public Policy Problems with the Science of Carcinogen Risk Assessment

Published online by Cambridge University Press:  28 February 2022

Carl F. Cranor
Carl F. Cranor*
Affiliation:
University of California
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Extract

Government agencies and private risk assessors use (quasi) scientific “risk assessment” procedures to try to estimate or predict risks to human health or the environment that might result from exposure to toxic substances in order to take steps to prevent such risks from arising or to eliminate the risks if they already exist We might think of this as an aspect of “regulatory science”.

Using carcinogen risk assessment as a model I consider several aspects of risk assessment—use of epidemiology, animal bioassays, and extrapolation models in predicting risks—to show how scientific procedures and uncertainties may determine (in a way often unbeknownst to the practitioners) the public policy debates concerning the estimation of risks from carcinogens.

For one thing, actual and possible scientific uncertainties are large enough that two different researchers using exactly the same data could come to quite different conclusions; such uncertainties permit risk assessors in large measure to determine regulatory decisions even though this exceeds their authority.

Type
Part XV. Risk Assessment
Information
PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association , Volume 1988 , Issue 2: Volume Two: Symposia and Invited Papers 1988 , 1988 , pp. 467 - 488
Copyright
Copyright © 1989 by the Philosophy of Science Association

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Footnotes

1

Research on the paper has been supported by a grant from the University of California Toxic Substances Research and Teaching Program for the UC Riverside Carcinogen Risk Assessment Project of which the author is the principle investigator. I am indebted to Deborah Mayo, D.V. Gokhale, and William Kemple and Kenneth Dickey for comments and criticisms on the ideas presented in this paper.

References

Cothern, Coniglio and Marcus, (1986), “Estimating Risks to Health,” Environmental Science and Technology III 20.Google Scholar
Cranor, C. (1983), “Epidemiology and Procedural Protections for Workplace Health in the Aftermath of the Benzene Case.” Industrial Relations Law Journal.Google Scholar
Cranor, C. (1987) “Some Public Policy Problems with Risk Assessment: How Good is the Use of the 95% Rule in Epidemiology?” Invited Symposium Paper, Pacific Division Meetings American Philosophical Association.Google Scholar
Feinstein, A. (1977), Clinical Biostatistics.CrossRefGoogle Scholar
Freedman, D. and Zeisel, H. (forthcoming). “From Mouse to Man: The Quantitative Assessment of Cancer Risks,” Statistical Science.Google Scholar
Lee, and Chang, A.C. (forthcoming), “An Evaluation of Transport Modeling of Organic Chemicals in Soil from Underground Fuel Tank Leaks.”Google Scholar
Giere, R. (1981) Understanding Scientific Reasoning.Google Scholar
Mayo, D. (1989), “Towards a More Objective Understanding of the Evidence of Carcinogenic Risk.” PSA 1988, Vol. 2, pp. 485–503.Google Scholar
National Cancer Institute, Demographic Analysis Section, Division of Cancer Cause and Prevention, (1981). Monograph No. 57. Surveillance, Epidemiology and End Results: Incidence and Mortality Data 1973-1977, pp. 662-63 and Table 51.Google Scholar
National Research Council, (1983), Risk Assessment in the Federal Government: Managing the Process. Washington, D.C.: U.S. Gov't Printing Office.Google Scholar
Needleman, and Billinger, (forthcoming), “Type II Fallacies in the Study of Childhood Exposure to Lead at Low Dose: A Critical and Quantitative Review.”Google Scholar
Page, T. (forthcoming). The Economics of Risk Assessment.Google Scholar
Rescher, N. (1983), Risk: A Philosophical Introduction to the Theory of Risk Evaluation and Management. Washington, D.C.: University Press of America.Google Scholar
U.S. Congress, Office of Technology Assessment (1987), Identifying and Regulating Carcinogens. Washington, D.C.: U.S. Government Printing Office.Google Scholar
U.S. Congress, Office of Technology Assessment (1981),Google Scholar
Walter (1977), “Determination of Significant Relevant Risks and Optimal Sampling Procedures in Prospective and Retrospective Studies of Various Sizes.” American Journal of Epidemiology 105: 387-91.CrossRefGoogle Scholar