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A Kernel of Truth? On the Reality of the Genetic Program

Published online by Cambridge University Press:  28 February 2022

Lenny Moss
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Extract

The full understanding of the nature of the genetic program was achieved by molecular biology only in the 1950's after the elucidation of the structure of DNA. Yet, it was already felt by the ancients that there had to be something that ordered the raw material into the patterned system of living beings….What is particularly important is that the genetic program itself remains unchanged while it sends out its instructions to the body.

One of the properties of the genetic program is that it can supervise its own precise replication and that of other living systems such as organelles, cells, and whole organisms.

Ernst Mayr (1982)

The notion of a genetic program, as described by Mayr, is ripe for an analysis inspired, at least in part, by recent debates in the philosophy of science taken under the heading of realism versus anti-realism.

Type
Part IX. Topics in the Philosophy of Biology
Information
PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association , Volume 1992 , Issue 1: Volume One: Contributed Papers 1992 , 1992 , pp. 335 - 348
Copyright
Copyright © 1992 by the Philosophy of Science Association

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Footnotes

1

This paper is an outgrowth of Arthur Fine’s Northwestern University graduate seminar on “Realism and Anti-realism.” I thank Professor Fine for his encouragement, and Professors Fine, David Hull, Thomas Ryckman, Susan Oyama, and Elizabeth Lloyd for their comments.

References

Allen, G. (1977), Life Science in the Twentieth Century. New York: John Wiley & Sons.Google Scholar
Bissell, MJ., Hall, G. and Parry, G.(1982), “How does the extracellular matrix direct gene expression?” Journal of Theoretical Biology 99:31-68.CrossRefGoogle ScholarPubMed
Chen, L.H. and Bissell, M.J. (1989), “A novel regulatory mechanism for whey acidic protein gene expression”. Cell Regulation 1:45-54.CrossRefGoogle ScholarPubMed
Coleman, W. (1977), Biology in the Nineteenth Century. Cambridge: Cambridge University Press.Google Scholar
Diamond, M., Miner, J., Yoshinaga, S. and Yamamoto, K. (1990) “Transcriptional factor interactions: selectors of positive or negative regulation from a single DNA element” Science 249:1266-1272.CrossRefGoogle ScholarPubMed
Emerman, J.T. and Pitelka, D.A. (1977), “Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes”. In Vitro 13:316-328.CrossRefGoogle ScholarPubMed
Emerman, J.T., Burwen, S.J. and Pitelka, D.A. (1979), “Substrate Properties influencing ultrastructural differentiation of mammary epithelial cells in culture”, Tissue Cell 11:109-119.CrossRefGoogle ScholarPubMed
Hull, D. (1974), Philosophy of Biological Sciences. Englewood Cliffs: Prentice-Hall.Google Scholar
Kant, I. (1987), Critique of Judgement. Indianapolis: Hackett Publishing Company.Google Scholar
Lee, E.Y., Lee, W.H., Kaetzel, C.S., Parry, G. and Bissell, M. (1985), “Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion”, Proceedings of the National Academy of Science 82:1419-1423.CrossRefGoogle ScholarPubMed
Lee, E.Y., Parry, G. and Bissell, M.J. (1984), “Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrate”, Journal of Cell Biology 98:146-155.CrossRefGoogle Scholar
Lenoir, T. (1982), The Strategy of Life. Chicago: University of Chicago Press.Google Scholar
Li, M.L., Aggelar, J., Farson, D.A., Hatier, C. and Bissell, M. (1987), “Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells”, Proceedings of the National Academy of Science 84:136-140.CrossRefGoogle ScholarPubMed
Mayr, E. (1982), The Growth of Biological Thought. Cambridge: Harvard University Press.Google Scholar
Mayr, E.. (1988), Toward a New Philosophy of Biology, Cambridge: Harvard University Press.Google Scholar
Moss, L. (1992), “Oncogenes, tumor suppressor genes, and the nature of cancer”, preprint.Google Scholar
Oyama, S. (1985), The Ontogeny of Information. Cambridge: Cambridge University Press.Google Scholar
Parry, G., Cullen, B., Kaetzel, C., Kramer, R. and Moss, L. (1987), “Regulation of differentiation and polarized secretion in mammary epithelial cells in culture, extracellular matrix and membrane polarity influences”, Journal of Cell Biology 105:2043-2051.CrossRefGoogle ScholarPubMed
Schrödinger, E. (1944), What is Life? Cambridge: Cambridge University Press.Google Scholar
Stent, G. (1986), “Hermeneutics and the analysis of complex biological systems” in Evolution at a Crossroads, Depew & Weber (eds.). Cambridge: The MIT Press.Google Scholar
Yamamoto, K. (1988), Unpublished lectures on gene regulation. University of California, San Francisco.Google Scholar