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The PA domain: A protease-associated domain

Published online by Cambridge University Press:  15 December 2000

PIERS MAHON  and
ALEX BATEMAN
PIERS MAHON
Affiliation:
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom
ALEX BATEMAN
Affiliation:
The Sanger Centre, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
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Abstract

We have identified a similarity between the apical domain of the human transferrin receptor and several other protein families. This domain is found associated with two different families of peptidases. Therefore, we term it the PA domain for protease-associated domain. The PA domain is found inserted within a loop of the peptidase domain of family M8/M33 zinc peptidases. The PA domain is also found in a vacuolar sorting receptor and a ring finger protein of unknown function that may be a cell surface receptor. The PA domain may mediate substrate determination of peptidases or form protein–protein interactions.

Keywords

aminopeptidase Ycell wall-associated serine proteasetransferrin receptorvacuolar receptor
Type
Research Article
Information
Protein Science , Volume 9 , Issue 10 , October 2000 , pp. 1930 - 1934
Copyright
© 2000 The Protein Society

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