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The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokine receptor homology region

Published online by Cambridge University Press:  01 January 1999

THOMAS KERNEBECK ,
STEFAN PFLANZ ,
GERHARD MÜLLER-NEWEN ,
GÜNTHER KURAPKAT ,
RUUD M. SCHEEK ,
KLAAS DIJKSTRA ,
PETER C. HEINRICH ,
AXEL WOLLMER ,
STEPHAN GRZESIEK  and
JOACHIM GRÖTZINGER
THOMAS KERNEBECK
Affiliation:
Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße 30, D-52057 Aachen, Germany
STEFAN PFLANZ
Affiliation:
Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße 30, D-52057 Aachen, Germany
GERHARD MÜLLER-NEWEN
Affiliation:
Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße 30, D-52057 Aachen, Germany
GÜNTHER KURAPKAT
Affiliation:
Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße 30, D-52057 Aachen, Germany
RUUD M. SCHEEK
Affiliation:
BIOSON Research Institute, University of Groningen, Nijenborgh 4, NL-9747 AG Groningen, The Netherlands
KLAAS DIJKSTRA
Affiliation:
BIOSON Research Institute, University of Groningen, Nijenborgh 4, NL-9747 AG Groningen, The Netherlands
PETER C. HEINRICH
Affiliation:
Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße 30, D-52057 Aachen, Germany
AXEL WOLLMER
Affiliation:
Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße 30, D-52057 Aachen, Germany
STEPHAN GRZESIEK
Affiliation:
Institut für Physikalische Biologie, Heinrich Heine Universität Düsseldorf, D-40225 Düsseldorf, Germany and Forschungszentrum Jülich, D-52425 Jülich, Germany
JOACHIM GRÖTZINGER
Affiliation:
Institut für Biochemie, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße 30, D-52057 Aachen, Germany
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Abstract

The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven β-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.

Keywords

gp130 domainNMR spectroscopystructure
Type
Research Article
Information
Protein Science , Volume 8 , Issue 1 , January 1999 , pp. 5 - 12
Copyright
© 1999 The Protein Society

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