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Night Eating Syndrome and Results from the First Placebo-Controlled Trial of Treatment, with the SSRI Medication, Sertraline: Implications for Clinical Practice

Published online by Cambridge University Press:  18 December 2007

John P. O'Reardon ,
Karen E. Groff ,
Albert J. Stunkard  and
Kelly C. Allison
John P. O'Reardon
Affiliation:
Weight & Eating Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA; Email: [email protected]
Karen E. Groff
Affiliation:
Weight & Eating Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Albert J. Stunkard
Affiliation:
Weight & Eating Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA; Email: [email protected]
Kelly C. Allison
Affiliation:
Weight & Eating Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA; Email: [email protected]
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Extract

ABSTRACT

Objective: The goal of the study was to assess the efficacy of sertraline in the treatment of the night eating syndrome (NES). Method: Thirty-four outpatients diagnosed with NES were randomly assigned to receive either sertraline (n = 17) or placebo (n = 17) in an 8-week, double-blind, flexible-dose (50–200 mg/day) study. We used the mixed effects linear regression model to analyze change in the primary outcome measure, the Clinical Global Impression of Improvement Scale (CGI-I). Secondary outcomes included changes in the Night Eating Symptom Scale (NESS), the number of nocturnal awakenings and ingestions, total daily calorie intake after the evening meal, Clinical Global Impression of Severity Scale (CGI-S), Quality of Life Enjoyment and Satisfaction Scale (Q-LES), and weight. Results: Sertraline was associated with statistically significantly greater improvements than placebo in the CGI-I scale. As determined by a CGI-I score of ≤2 (much or very much improved), 12 subjects in the sertraline group (71%) were classified as responders versus only 3 in the placebo group (18%). There were also significant improvements in the NESS, CGI-S scales, Q-LES, frequency of nocturnal ingestions and awakenings, and calorie intake after supper. Overweight and obese subjects in the sertraline group (n = 14) lost a significant amount of weight by week 8 (mean = −2.9, SD = 3.8 kg) compared to those in the placebo arm (n = 13) (mean = −0.3, SD = 2.7 kg). Conclusions: In this 8-week trial, sertraline was effective in the treatment of NES and was well tolerated.

Keywords

night eating syndromeplacebo-controlled trialsertraline.
Type
Research Article
Information
Progress in Neurotherapeutics and Neuropsychopharmacology , Volume 3 , Issue 1 , January 2008 , pp. 241 - 257
Copyright
© 2008 Cambridge University Press

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References

Allison, K.C., & Stunkard, A.J. (2005). Obesity and eating disorders. Psychiatric Clinics of North America, 28, 55–67.Google Scholar
Allison, K.C., Martino, N.S., O'Reardon, J.P., & Stunkard, A.J. (2005a). CBT treatment of night eating syndrome: a pilot study. Obesity Research, 13, A83.Google Scholar
Allison, K.C., Grilo, C.M., Masheb, R.M., & Stunkard, A.J. (2005b). Binge eating disorder and night eating syndrome: a comparative study of disordered eating. Journal of Consulting and Clinical Psychology, 73 (6), 1107–1115.Google Scholar
Andersen, G.S., Stunkard, A.J., Sorensen, T.I., Petersen, L., & Heitmann, B.L. (2004). Night eating and weight change in middle-aged men and women. International Journal of Obesity and Related Metabolic Disorder, 28, 1338–1343.Google Scholar
Auger, R. (2006). Sleep-related eating disorder. Psychiatry, 11, 64–69.Google Scholar
Beck, A.T., Steer, R.A., & Garbin, M.G. (1988). Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clinical Psychology Review, 8, 77–100.Google Scholar
Birketvedt, G.S., Florholmen, J., Sundsfjord, J., Osterud, B., Dinges, D., Bilker, W., & Stunkard, A.J. (1999). Behavioral and neuroendocrine characteristics of the night eating syndrome. Journal of the American Medical Association, 282, 657–663.Google Scholar
Endicott, J., Nee, J., Harrison, W., & Blumenthal, R. (1993). Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q): a new measure. Psychopharmacology Bulletin, 29, 321–326.Google Scholar
Friedman, S., Even, C., Dardennes, R., & Guelfi, J.D. (2002). Light therapy, obesity, and night-eating syndrome. The American Journal of Psychiatry, 159, 875–876.Google Scholar
Gluck, M.E., Geliebter, A., & Satov, T. (2001). Night eating syndrome is associated with depression, low self-esteem, reduced daytime hunger, and less weight loss in obese outpatients. Obesity Research, 9, 264–267.Google Scholar
Goldstein, D.J., Wilson, M.G., Thompson, J.H., Potvin, J.H., & Rampey Jr., A.H. (1995). Long-term treatment of bulimia nervosa. Fluoxetine bulimia nervosa research group. The British Journal of Psychiatry, 166, 660–666.Google Scholar
James, S. (1991). The approximate multinormal probabilities applied to correlated multiple endpoints in clinical trials. Statistics in Medicine, 10, 1123–1135.Google Scholar
Leon, A.C., & Heo, M. (2005). A comparison of multiplicity adjustment strategies for correlated binary endpoints. Journal of Biopharmaceutical Statistics, 15, 839–855.Google Scholar
Lundgren, J.D., et al. (2006). Prevalence of the night eating syndrome in a psychiatric population. American Journal of Psychiatry, 163 (1), 156–158.Google Scholar
Marshall, H.M., Allison, K.C., O'Reardon, J.O., Birketvedt, G., & Stunkard, A.J. (2004). The night eating syndrome among nonobese persons. International Journal of Eating Disorders, 35, 217–222.Google Scholar
Miller, J.D., Morin, L.P., Schwartz, W.J., & Moore, R.Y. (1996). New insights into the mammalian circadian clock. Sleep, 19, 641–667.Google Scholar
Miyaoka, T., et al. (2003). Successful treatment of nocturnal eating/drinking syndrome with selective serotonin reuptake inhibitors. International Clinical Psychopharmacology, 18 (3), 175–177.Google Scholar
Nestle, M., & Jacobson, M. (2000). Halting the obesity epidemic: a public health policy approach. Public Health Reports, 115, 12–24.Google Scholar
O'Reardon, J.P., Allison, K.C., & Stunkard, A.J. (2004). A clinical trial of sertraline in the treatment of the night eating syndrome. International Journal of Eating Disorders, 35, 16–26.Google Scholar
O'Reardon, J.P., Ringel, B.L., Dinges, D.F., Allison, K.C., Rogers, N.L., Martino, N.S., & Stunkard, A.J. (2004). Circadian eating and sleeping patterns in the night eating syndrome. Obesity Research, 12, 1789–1796.Google Scholar
O'Reardon, J.P., Peshek, A., & Allison, K. (2005). Night eating syndrome: diagnosis, epidemiology, and management. CNS Drugs, 19 (12), 997–1008.Google Scholar
Pawlow, L.A., O'Neil, P.M., & Malcolm, R.J. (2003). Night eating syndrome: effects of brief relaxation training on stress, mood hunger and eating patterns. International Journal of Obesity Related Metabolic Disorders, 27, 970–978.Google Scholar
Rand, C.S., MacGreggor, A.M.C., & Stunkard, A.J. (1997). The night eating syndrome in the general population and among postoperative obesity surgery patients. International Journal of Eating Disorders, 22, 65–69.Google Scholar
Rush, A.J., et al. (2006). Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. New England Journal of Medicine, 354 (12), 1231–1242.Google Scholar
Spaggiari, M.C., Granella, F., Parrino, L., Marchesi, C., Melli, I., & Terzano, M.G. (1994). Nocturnal eating syndrome in adults. Sleep, 17, 339–344.Google Scholar
Stunkard, A.J., Grace, W.J., & Wolff, H.G. (1955). The night eating syndrome: a pattern of food intake in certain obese patients. American Journal of Medicine, 19, 78–86.Google Scholar
Stunkard, A.J., Berkowitz, R., Wadden, T., Tanrikut, C., Reiss, E., & Young, L. (1996). Binge eating disorder and the night eating syndrome. International Journal of Obesity of Related Metabolic Disorders, 20, 1–6.Google Scholar
Stunkard, A.J., Allison, K.C., Lundgren, J.D., Martino, N., Heo, M., Etemad, B., & O'Reardon, J.P. (2006). A paradigm for facilitating pharmacotherapy at a distance: treatment of the night eating syndrome. Journal of Clinical Psychiatry, 67, 1568–1572.Google Scholar
Verbeke, G., & Molenberghs, G. (1997). Linear Mixed Models in Practice. A SAS-oriented Approach. New York: Springer, pp. 222–233.
Winkelman, J.W. (2003). Treatment of nocturnal eating syndrome and sleep-related eating disorder with topiramate. Sleep Medicine, 4, 243–246.Google Scholar