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XIII.—The Genetic Basis of Alkaptonuria

Published online by Cambridge University Press:  15 September 2014

Lancelot Hogben ,
R. L. Worrall  and
I. Zieve
Lancelot Hogben
Affiliation:
Department of Social Biology, University of London
R. L. Worrall
Affiliation:
Department of Social Biology, University of London
I. Zieve
Affiliation:
Department of Social Biology, University of London
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Summary

1. The overwhelming majority of cases of alkaptonuria are consistent with the hypothesis that this disease is determined by a single autosomal recessive gene substitution.

2. The observed proportion of alkaptonurics in recorded fraternities with two normal parents and the incidence of consanguineous parentage conform quantitatively to the requirements of Mendelian hypothesis in a system of random mating.

3. There appears to be an alternative form of alkaptonuria which is dominant.

Grateful acknowledgment is made to Sir Archibald Garrod for advice regarding the sources consulted.

Type
Proceedings
Information
Proceedings of the Royal Society of Edinburgh , Volume 52 , 1933 , pp. 264 - 295
Copyright
Copyright © Royal Society of Edinburgh 1933

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References

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