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Understanding the aetiology of childhood obesity: implications for treatment

Published online by Cambridge University Press:  07 March 2007

Jane Wardle
Affiliation:
Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, 2–16 Torrington Place, London WC1E 6BT, UK
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Abstract

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Childhood obesity poses one of the greatest challenges to paediatric health in the 21st century. Developing effective strategies for treatment and prevention is therefore a priority for clinical medicine and public health. This process is taking place at a time of unprecedented change in the understanding of the role of genetic factors in human health and disease, and genetic research into obesity has challenged assumptions about causal processes. In the spirit of the conference theme, the present paper will discuss the implications of the understanding of genetic and environmental influences on obesity for the development of effective behavioural treatments.

Type
Symposium on ‘Biology of obesity’
Copyright
Copyright © The Nutrition Society 2005

References

Allison, DB, Kaprio, J, Korkeila, M, Koskenvuo, M, Neale, MC & Hayakawa, K (1996) The heritability of body mass index among an international sample of monozygotic twins reared apart. International Journal of Obesity and Related Metabolic Disorders 20, 501506.Google ScholarPubMed
Barkeling, B, Ekman, S & Rossner, S (1992) Eating behaviour in obese and normal weight 11-year-old children. International Journal of Obesity and Related Metabolic Disorders 16, 355360.Google ScholarPubMed
Barsh, GS, Farooqi, IS, O'Rahilly, S (2000) Genetics of body-weight regulation. Nature 404, 644651.CrossRefGoogle ScholarPubMed
Bell, AC, Ge, K & Popkin, BM (2002) The road to obesity or the path to prevention: motorized transportation and obesity in China. Obesity Research 10, 277283.CrossRefGoogle ScholarPubMed
Bibi, H, Shoseyov, D, Feigenbaum, D, Genis, M, Friger, M, Peled, R & Sharff, S (2004) The relationship between asthma and obesity in children: is it real or a case of over diagnosis. Journal of Asthma 41, 403410.CrossRefGoogle ScholarPubMed
Bougneres, P (2002) Genetics of obesity and type 2 diabetes: tracking pathogenic traits during the predisease period. Diabetes 51, Suppl. 3, S295S303.CrossRefGoogle ScholarPubMed
Braet, C, Van Strien, T (1997) Assessment of emotional, externally induced and restrained eating behaviour in nine to twelve-year-old obese and non-obese children. Behaviour Research and Therapy 35, 863873.CrossRefGoogle ScholarPubMed
Brownell, KD (2004) Food Fight. New York: McGraw-Hill.Google Scholar
Burdette, HL & Whitaker, RC (2004) Neighborhood playgrounds, fast food restaurants, and crime: relationships to overweight in low-income preschool children. Preventive Medicine 38, 5763.CrossRefGoogle ScholarPubMed
Cole, TJ, Bellizzi, MC, Flegal, KM & Dietz, WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. British Medical Journal 320, 12401243.CrossRefGoogle ScholarPubMed
Cummings, DE & Schwartz, MW (2003) Genetics and pathophysiology of human obesity. Annual Review of Medicine 54, 453471.CrossRefGoogle ScholarPubMed
Epstein, LH, McCurley, J, Wing, RR & Valoski, A (1990a) Five-year follow-up of family-based behavioral treatments for childhood obesity. Journal of Consulting and Clinical Psychology 58, 661664.CrossRefGoogle ScholarPubMed
Epstein, LH, Paluch, RA, Gordy, CC & Dorn, J (2000) Decreasing sedentary behaviors in treating pediatric obesity. Archives of Pediatrics and Adolescent Medicine 154, 220226.CrossRefGoogle ScholarPubMed
Epstein, LH, Roemmich, JN & Raynor, HA (2001) Behavioral therapy in the treatment of pediatric obesity. Pediatric Clinics of North America 48, 981993.CrossRefGoogle ScholarPubMed
Epstein, LH, Smith, JA, Vara, LS & Rodefer, JS (1991) Behavioral economic analysis of activity choice in obese children. Health Psychology 10, 311316.CrossRefGoogle ScholarPubMed
Epstein, LH, Valoski, A, Wing, RR & McCurley, J (1990b) Ten-year follow-up of behavioral, family-based treatment for obese children. Journal of the American Medical Association 264, 25192523.CrossRefGoogle ScholarPubMed
Epstein, LH, Valoski, A, Wing, RR & McCurley, J (1994) Ten-year outcomes of behavioral family-based treatment for childhood obesity. Health Psychology 13, 373383.CrossRefGoogle ScholarPubMed
Faith, MS, Johnson, SL & Allison, DB (1997) Putting the behavior into the behavior genetics of obesity. Behavior Genetics 27, 423439.CrossRefGoogle ScholarPubMed
Fisher, JO & Birch, LL (1999) Restricting access to palatable foods affects children's behavioral response, food selection, and intake. American Journal of Clinical Nutrition 69, 12641272.CrossRefGoogle ScholarPubMed
Frank, LD, Andresen, MA & Schmid, TL (2004) Obesity relationships with community design, physical activity, and time spent in cars. American Journal of Preventive Medicine 27, 8796.CrossRefGoogle ScholarPubMed
Fuentes, RM, Notkola, IL, Shemeikka, S, Tuomilehto, J & Nissinen, A (2003) Tracking of body mass index during childhood: a 15-year prospective population-based family study in eastern Finland. International Journal of Obesity and Related Metabolic Disorders 27, 716721.CrossRefGoogle ScholarPubMed
Goran, MI, Ball, GD & Cruz, ML (2003) Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. Journal of Clinical Endocrinology and Metabolism 88, 14171427.CrossRefGoogle ScholarPubMed
Gortmaker, SL, Must, A, Perrin, JM, Sobol, AM & Dietz, WH (1993) Social and economic consequences of overweight in adolescence and young adulthood. New England Journal of Medicine 329, 10081012.CrossRefGoogle ScholarPubMed
Grilo, CM, Pogue-Geile, MF (1991) The nature of environmental influences on weight and obesity: a behavior genetic analysis. Psychological Bulletin 110, 520537.CrossRefGoogle ScholarPubMed
Hedley, AA, Ogden, CL, Johnson, CL, Carroll, MD, Curtin, LR & Flegal, KM (2004) Prevalence of overweight and obesity among US children, adolescents, and adults 1999–2002. Journal of the American Medical Association 291, 28472850.CrossRefGoogle ScholarPubMed
Herman, CP & Polivy, J (1975) Anxiety, restraint, and eating behavior. Journal of Abnormal Psychology 84, 6672.CrossRefGoogle ScholarPubMed
Heude, B, Lafay, L, Borys, JM, Thibult, N, Lommez, A, Romon, M, Ducimetiere, P & Charles, MA (2003) Time trend in height, weight, and obesity prevalence in school children from Northern France 1992–2000. Diabetes and Metabolism 29, 235240.CrossRefGoogle ScholarPubMed
Hewitt, JK (1997) The genetics of obesity: what have genetic studies told us about the environment. Behavior Genetics 27, 353358.CrossRefGoogle ScholarPubMed
Jansen, A, Theunissen, N, Slechten, K, Nederkoorn, C, Boon, B, Mulkens, S & Roefs, A (2003) Overweight children overeat after exposure to food cues. Eating Behaviors 4, 197209.CrossRefGoogle ScholarPubMed
Jeffery, RW & Utter, J (2003) The changing environment and population obesity in the United States. Obesity Research 11, Suppl., 12S22S.CrossRefGoogle ScholarPubMed
Johnson, F & Wardle, J (2005) Dietary restraint, body dissatisfaction and psychological distress: a prospective analysis. Journal of Abnormal Psychology 114, (In Press).CrossRefGoogle ScholarPubMed
Koeppen-Schomerus, G, Wardle, J & Plomin, R (2001) A genetic analysis of weight and overweight in 4-year-old twin pairs. International Journal of Obesity and Related Metabolic Disorders 25, 838844.CrossRefGoogle ScholarPubMed
Kozlowski, LT & Schachter, S (1975) Effects of cue prominence and palatability on the drinking behavior of obese and normal humans. Journal of Personality and Social Psychology 32, 10551059.CrossRefGoogle ScholarPubMed
Lake, JK, Power, C & Cole, TJ (1997) Child to adult body mass index in the 1958 British birth cohort: associations with parental obesity. Archives of Disease in Childhood 77, 376381.CrossRefGoogle ScholarPubMed
Lamertz, CM, Jacobi, C, Yassouridis, A, Arnold, K & Henkel, AW (2002) Are obese adolescents and young adults at higher risk for mental disorders? A community survey. Obesity Research 10, 11521160.CrossRefGoogle Scholar
McElroy, SL, Kotwal, R, Malhotra, S, Nelson, EB, Keck, PE & Nemeroff, CB (2004) Are mood disorders and obesity related? A review for the mental health professional. Journal of Clinical Psychiatry 65, 634651.CrossRefGoogle ScholarPubMed
McTigue, KM, Garrett, JM & Popkin, BM (2002) The natural history of the development of obesity in a cohort of young U.S. adults between 1981 and 1998. Annals of Internal Medicine 136, 857864.CrossRefGoogle Scholar
Montague, CT, Farooqi, IS, Whitehead, JP, Soos, MA, Rau, H, Wareham, NJ et al. (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903908.CrossRefGoogle ScholarPubMed
Must, A, Jacques, PF, Dallal, GE, Bajema, CJ & Dietz, WH (1992) Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. New England Journal of Medicine 327, 13501355.CrossRefGoogle ScholarPubMed
Peters, JC, Wyatt, HR, Donahoo, WT & Hill, JO (2002) From instinct to intellect: the challenge of maintaining healthy weight in the modern world. Obesity Reviews 3, 6974.CrossRefGoogle ScholarPubMed
Plomin, R, Owen, MJ & McGuffin, P (1994) The genetic basis of complex human behaviors. Science 264, 17331739.CrossRefGoogle ScholarPubMed
Power, C, Lake, JK & Cole, TJ (1997) Measurement and long-term health risks of child and adolescent fatness. International Journal of Obesity and Related Metabolic Disorders 21, 507526.CrossRefGoogle ScholarPubMed
Prentice, AM & Jebb, SA (2003) Fast foods, energy density and obesity: a possible mechanistic link. Obesity Reviews 4, 187194.CrossRefGoogle ScholarPubMed
Puhl, R & Brownell, KD (2001) Bias, discrimination, and obesity. Obesity Research 9, 788805.CrossRefGoogle ScholarPubMed
Robinson, TN, Kiernan, M, Matheson, DM & Haydel, KF (2001) Is parental control over children's eating associated with childhood obesity? Results from a population-based sample of third graders. Obesity Research 9, 306312.CrossRefGoogle ScholarPubMed
Rodin, J (1981) Current status of the internal-external hypothesis for obesity: what went wrong. American Psychologist 36, 361372.CrossRefGoogle ScholarPubMed
Rodin, J & Slochower, J (1976) Externality in the nonobese: effects of environmental responsiveness on weight. Journal of Personality and Social Psychology 33, 338344.CrossRefGoogle ScholarPubMed
Saelens, BE & Epstein, LH (1996) Reinforcing value of food in obese and non-obese women. Appetite 27, 4150.CrossRefGoogle ScholarPubMed
Schachter, S (1968) Obesity and eating. Internal and external cues differentially affect the eating behavior of obese and normal subjects. Science 161, 751756.CrossRefGoogle ScholarPubMed
Smith, JA & Epstein, LH (1991) Behavioral economic analysis of food choice in obese children. Appetite 17, 9195.CrossRefGoogle ScholarPubMed
Sorensen, TI & Stunkard, AJ (1993) Does obesity run in families because of genes? An adoption study using silhouettes as a measure of obesity. Acta Psychiatrica Scandinavica 370, Suppl., 6772.CrossRefGoogle ScholarPubMed
Strauss, RS & Knight, J (1999) Influence of the home environment on the development of obesity in children. Pediatrics 103, e85.CrossRefGoogle ScholarPubMed
Strauss, RS & Pollack, HA (2003) Social marginalization of overweight children. Archives of Pediatrics and Adolescent Medicine 157, 746752.CrossRefGoogle ScholarPubMed
Stunkard, AJ, Harris, JR, Pedersen, NL & McClearn, GE (1990) The body-mass index of twins who have been reared apart. New England Journal of Medicine 322, 14831487.CrossRefGoogle ScholarPubMed
Stunkard, AJ, Sorensen, TI, Hanis, C, Teasdale, TW, Chakraborty, R, Schull, WJ & Schulsinger, F (1986) An adoption study of human obesity. New England Journal of Medicine 314, 193198.CrossRefGoogle ScholarPubMed
Sturm, R (2002) The effects of obesity, smoking, and drinking on medical problems and costs. Obesity outranks both smoking and drinking in its deleterious effects on health and health costs. Health Affairs 21, 245253.CrossRefGoogle Scholar
Sturm, R (2003) Increases in clinically severe obesity in the United States 1986–2000. Archives of Internal Medicine 163, 21462148.CrossRefGoogle ScholarPubMed
Thompson, D & Wolf, AM (2001) The medical-care cost burden of obesity. Obesity Reviews 2, 189197.CrossRefGoogle ScholarPubMed
Thomsen, BL, Ekstrom, CT & Sorensen, TI (1999) Development of the obesity epidemic in Denmark: cohort, time and age effects among boys born 1930–1975. International Journal of Obesity and Related Metabolic Disorders 23, 693701.CrossRefGoogle ScholarPubMed
Wardle, J (2004) Parent feeding and children's eating and weight. Pediatrics 114, Suppl. 1, 11611165.Google Scholar
Wardle, J, Guthrie, C, Sanderson, S, Birch, L & Plomin, R (2001) Food and activity preferences in children of lean and obese parents. International Journal of Obesity and Related Metabolic Disorders 25, 971977.CrossRefGoogle ScholarPubMed
Wardle, J, Sanderson, S, Guthrie, CA, Rapoport, L & Plomin, R (2002a) Parental feeding style and the inter-generational transmission of obesity risk. Obesity Research 10, 453462.CrossRefGoogle ScholarPubMed
Wardle, J, Waller, J & Fox, E (2002b) Age of onset and body dissatisfaction in obesity. Addictive Behaviors 27, 561573.CrossRefGoogle ScholarPubMed
Wing, YK, Hui, SH, Pak, WM, Ho, CK, Cheung, A, Li, AM & Fok, TF (2003) A controlled study of sleep related disordered breathing in obese children. Archives of Disease in Childhood 88, 10431047.CrossRefGoogle ScholarPubMed
Wrotniak, BH, Epstein, LH, Paluch, RA & Roemmich, JN (2004) Parent weight change as a predictor of child weight change in family-based behavioral obesity treatment. Archives of Pediatrics and Adolescent Medicine 158, 342347.CrossRefGoogle ScholarPubMed
Zhang, Y, Proenca, R, Maffei, M, Barone, M, Leopold, L & Friedman, JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425432.CrossRefGoogle ScholarPubMed