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Tissue engineering of the gastrointestinal tract for surgical replacement: a nutrition tool of the future?

Published online by Cambridge University Press:  05 March 2007

Tracy C. Grikscheit
Tracy C. Grikscheit*
Affiliation:
Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
*
Corresponding author: Dr Tracy Grikscheit, fax +1 801 730 9061, [email protected]
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Abstract

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Optimal nutrition depends on the multiple complex functions performed by the gastrointestinal tract, which range from basic functions such as storage, conduit and mechanical processing to more finely regulated capabilities such as vectorial transport, immune defence and cell signalling. Surgical strategies to supply lacking gastrointestinal tract tissues have relied on either replacement by proxy (surgical substitution) or the introduction of prostheses. Tissue engineering seeks to replace missing tissues with engineered tissues that more accurately reproduce the native physiological and anatomical milieu. It is now possible to engineer several areas of the gastrointestinal tract with high fidelity, and to employ tissue-engineered bowel in replacement in animal models. These replacement models have reflected excellent anatomical and physiological recapitulation of native bowel by the tissue-engineered constructs in vivo.

Keywords

Tissue engineeringGastrointestinal tract replacementAnimal models
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 3 , August 2003 , pp. 739 - 743
Copyright
Copyright © The Nutrition Society 2003

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