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Rye, lignans and human health

Published online by Cambridge University Press:  05 March 2007

Göran Hallmans ,
Jie-Xian Zhang ,
Eva Lundin ,
PäR Stattin ,
Anders Johansson ,
Ingegerd Johansson ,
Kerstin Hultén ,
Anna Winkvist ,
Per Lenner  and
Per Åman
...Show all authors
Göran Hallmans
Affiliation:
Department of Public Health and Clinical Medicine, University of Umeå, SE-901 87, Umeå, Sweden
Jie-Xian Zhang*
Affiliation:
Department of Public Health and Clinical Medicine, University of Umeå, SE-901 87, Umeå, Sweden
Eva Lundin
Affiliation:
Department of Pathology, University of Umeå, SE-901 87, Umeå, Sweden
PäR Stattin
Affiliation:
Department of Urology, University of Umeå, SE-901 87, Umeå, Sweden
Anders Johansson
Affiliation:
Department of Public Health and Clinical Medicine, University of Umeå, SE-901 87, Umeå, Sweden
Ingegerd Johansson
Affiliation:
Department of Public Health and Clinical Medicine, University of Umeå, SE-901 87, Umeå, Sweden
Kerstin Hultén
Affiliation:
Department of Public Health and Clinical Medicine, University of Umeå, SE-901 87, Umeå, Sweden
Anna Winkvist
Affiliation:
Department of Public Health and Clinical Medicine, University of Umeå, SE-901 87, Umeå, Sweden
Per Lenner
Affiliation:
Department of Oncology, University of Umeå, SE-901 87, Umeå, Sweden
Per Åman
Affiliation:
Department of Food Sciences, Swedish University of Agricultural Sciences, SE-750 07, Uppsala, Sweden
Herman Adlercreutz
Affiliation:
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Centre, and, Department of Clinical Chemistry, University of Helsinki, Finland
*
*Corresponding author: Dr Jie-Xian Zhang, fax +46 90 7852642, [email protected]
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Abstract

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Rye bran contains a high content not only of dietary fibre, but also of plant lignans and other bioactive compounds in the so-called dietary fibre complex. Blood concentrations of lignans such as enterolactone have been used as biomarkers of intake of lignan-rich plant food. At present, evidence from studies in human subjects does not warrant the conclusion that rye, whole grains or phyto-oestrogens protect against cancer. Some studies, however, have pointed in that direction, especially in relation to cancers of the upper digestive tract. A number of prospective epidemiological studies have clearly shown a protective effect of whole-grain cereals against myocardial infarctions. A corresponding protective effect against diabetes and ischaemic stroke (brain infarct) has also been demonstrated. It seems reasonable to assume that these protective effects are associated with one or more factors in the dietary fibre complex.

Keywords

RyeLignansDietary fibreCancerCardiovascular diseaseDiabetes mellitus
Type
Session: Nutrients contributing to the fibre effect
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 1 , February 2003 , pp. 193 - 199
Copyright
Copyright © The Nutrition Society 2003

References

Adlercreutz, H, Honjo, H, Higashi, A, Fotsis, T, Hämäläinen, E, Hasegawa, T & Okada, H (1991) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. American Journal of Clinical Nutrition 54, 1093–1100.CrossRefGoogle ScholarPubMed
Adlercreutz, H, Markkanen, H & Watanabe, S (1993) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342, 1209–1210.CrossRefGoogle ScholarPubMed
Adlercreutz, H & Mazur, W (1997) Phyto-oestrogens and Western diseases. Annals of Medicine 29, 95–120.CrossRefGoogle ScholarPubMed
Berglund, O, Hallmans, G, Nygren, C & Taljedal, IB (1982) Effects of diets rich and poor in fibres on the development of hereditary diabetes in mice. Acta Endocrinologia (Copenhagen) 100, 556–564.Google ScholarPubMed
Bosello, O, Ostuzzi, R, Armellini, F, Micciolo, R & Scuro, LA (1980) Glucose tolerance and blood lipids in bran-fed patients with impaired glucose tolerance. Diabetes Care 3, 46–49.CrossRefGoogle ScholarPubMed
Brodribb, AJ & Humphreys, DM (1976) Diverticular disease: three studies. Part III – Metabolic effect of bran in patients with diverticular disease. British Medical Journal 1, 428–430.CrossRefGoogle ScholarPubMed
Bylund, A, Zhang, JX, Bergh, A, Damber, JE, Widmark, A, Johansson, A, Adlercreutz, H, Aman, P, Shepherd, MJ & Hallmans, G (2000) Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate 42, 304–314.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Demark-Wahnefried, W, Price, DT, Polascik, TJ, Robertson, CN, Anderson, EE, Paulson, DF, Walther, PJ, Gannon, M & Vollmer, RT (2001) Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology 58, 47–52.CrossRefGoogle ScholarPubMed
den Tonkelaar, I, Keinan-Boker, L, Veer, PV, Arts, CJ, Adlercreutz, H, Thijssen, JH, Peeters, PHM (2001) Urinary phytoestrogens and postmenopausal breast cancer risk. Cancer Epidemiology, Biomarkers and Prevention 10, 223–228.Google ScholarPubMed
Fuchs, CS, Giovannucci, EL, Colditz, GA, Hunter, DJ, Stampfer, MJ, Rosner, B, Speizer, FE & Willett, WC (1999) Dietary fiber and the risk of colorectal cancer and adenoma in women. New England Journal of Medicine 340, 69–176.CrossRefGoogle ScholarPubMed
Hallmans, G, Zhang, JX, Lundin, E, Bergh, A, Sylvan, A, Bylund, A, Widmark, A, Stattin, P, Damber, JE, Åman, P, Johansson, A & Adlercreutz, H (1999) Metabolism of lignans and their relation to prostate cancer. In Phytoestrogens: Exposure, Bioavailability, Health Benefits and Safety Concerns. Proceedings of International Symposium, COST 916, Bioactive Plant Cell Wall Components in Nutrition and Health, pp 65–72 [Bausch-Goldbohm, S, Kardinaal, A and Serra, F, editors]. Doorweth, The Netherlands: Commission of European CommunitiesGoogle Scholar
Heinonen, S, Nurmi, T, Liukkonen, K, Poutanen, K, Wähälä, K, Deyama, T, Nishibe, S & Adlercreutz, H (2001) In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. Journal of Agricultural and Food Chemistry 49, 3178–3186.CrossRefGoogle ScholarPubMed
Hirayama, T (1979) Epidemiology of prostate cancer with special reference to the role of diet. National Cancer Institute Monographs 53, 149–155.Google Scholar
Hultén, K, Winkvist, A, Lenner, P, Johansson, R, Adlercreutz, H & Hallmans, G (2002) An incident case referent study on plasma enterolactone and breast cancer risk. European Journal of Nutrition 41, 168–176.CrossRefGoogle ScholarPubMed
Ingram, D, Sanders, K, Kolybaba, M & Lopez, D (1997) Casecontrol study of phyto-oestrogens and breast cancer. Lancet 350, 990–994.CrossRefGoogle ScholarPubMed
Jacobs, DR (2001) The health relevance of whole grain Whole Grain and Human Health, Proceedings of International Symposium VTT 213, Espoo, Finland, pp.17–18 [Liukkonen, K, Kuokka, A and Poutanen, K, editors]. Espoo, Finland: VTTGoogle Scholar
Jacobs, DR Jr, Meyer, KA, Kushi, LH, Folsom, AR (1998) Wholegrain intake may reduce the risk of ischemic heart disease death in postmenopausal women: The Iowa Women's Health Study. American Journal of Clinical Nutrition 68, 248–257.CrossRefGoogle ScholarPubMed
Juntunen, K, Witold, M, Liukkonen, K, Mariko, U, Poutanen, K, Adlercreutz, H, Mykkänen, H (2000) Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with wheat bread in healthy Finnish men and women. British Journal of Nutrition 84, 839–846.CrossRefGoogle ScholarPubMed
Key, TJA, Silcocks, PB, Davey, GK, Appleby, PN & Bishop, DT (1997) A case control study of diet and prostate cancer. British Journal of Cancer 76, 678–687.CrossRefGoogle ScholarPubMed
Khaw, KT, Bingham, S, Welch, A, Luben, R, Wareham, N, Oakes, S & Day, N (2001) Relation between plasma ascorbic acid and mortality in men and women in EPIC – Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 357, 657–663.CrossRefGoogle ScholarPubMed
Kilkkinen, A, Stumpf, K, Pietinen, P, Valsta, LM, Tapanainen, H & Adlercreutz, H (2001) Determinants of serum enterolactone concentration. American Journal of Clinical Nutrition 73, 1094–1100.CrossRefGoogle ScholarPubMed
Kleemola, P, Virtanen, M & Pietinen, P (1994) The 1992 Dietary Survey of Finnish Adults. Helsinki, Finland: Helsinki National Public Health Institute, Department of NutritionGoogle Scholar
Kurtz, RC & Zhang, ZF (2001) Gastric cardia cancer and dietary fiber. Gastroenterology 120, 568–570.CrossRefGoogle ScholarPubMed
Landström, M, Zhang, JX, Hallmans, G, Åman, P, Berg, A, Damber, JE, Mazur, W, Wähälä, K & Adlercreutz, H (1998) Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats. Prostate 36, 151–161.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Linko, AM, Parikka, K, Wähälä, K & Adlercreutz, H (2002) Gas chromatographic-mass spectrometric method for the determination of alkylresorcinols in human plasma. Analytical Biochemistry 308, 307–313.CrossRefGoogle ScholarPubMed
Liu, S, Buring, JE, Sesso, HD, Rimm, EB, Willett, WC & Manson, JE (2002) A prospective study of dietary fiber intake and risk of cardiovascular disease among women. Journal of the American College of Cardiology 39, 49–56.CrossRefGoogle ScholarPubMed
Liu, S, Manson, JE, Stampfer, MJ, Rexrode, KM, Hu, FB, Rimm, EB & Willett, WC (2000) Whole grain consumption and risk of ischemic stroke in women: A prospective study. Journal of the American Medical Association 284, 1534–1540.CrossRefGoogle ScholarPubMed
Lundin, E, Adlercreutz, H, Bianchini, F, Stenling, R, Riboli, E, Kaaks, R, Hallmans, G & Palmqvist, R (2001a) No association between plasma enterolactone and colorectal cancer risk in a prospective study. In The Dietary Fiber Complex, Intestinal Function and Metabolic Effects. Experimental and Epidemiology Studies. Umeå University Medical Dissertation. Umeå, Sweden: Umeå University.Google Scholar
Lundin, E, Nygren, C, Berglund, O, Zhang, JX, Höstedt, P, Hallmans, G & Stenling, R (2001b) Effects of a rye bran diet and a fiber free diet on the morphology of the small intestine of diabetic and control mice. A scanning and transmission electron microscopy study. In The Dietary Fiber Complex, Intestinal Function and Metabolic Effects. Experimental and Epidemiology Studies. Umeå University Medical Dissertation. Umeå, Sweden: Umeå University.Google Scholar
Mazur, W (1998) Phytoestrogen content in foods. Bailliere's Clinical Endocrinology and Metabolism 12, 729–742.CrossRefGoogle ScholarPubMed
Mazur, W & Adlercreutz, H (1998) Naturally occurring oestrogens in food. Pure and Applied Chemistry 70, 1759–1776.CrossRefGoogle Scholar
Mazur, W, Fotsis, T, Wähälä, K, Ojala, S, Salakka, A & Adlercreutz, H (1996) Isotope dilution gas chromatographic–mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples. Analytical Biochemistry 233, 169–180.CrossRefGoogle ScholarPubMed
Meyer, F, Bairati, I, Shadimani, R, Fradet, Y & Moore, L (1999) Dietary fat and prostate cancer survival. Cancer Causes and Control 10, 245–251.CrossRefGoogle ScholarPubMed
Meyer, KA, Kushi, LH, Jacobs, DR Jr, Slavin, J, Sellers, TA & Folsom, AR (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. American Journal of Clinical Nutrition 71, 921–930.CrossRefGoogle ScholarPubMed
Mills, P, Beeson, B, Phillips, R & Fraser, G (1989) Cohort study of diet, lifestyle and prostate cancer in Adventist men. Cancer 64, 598–604.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Morris, JN, Marr, JW & Clayton, DG (1977) Diet and heart: A postscript. British Medical Journal 2, 1307–1314.CrossRefGoogle Scholar
Nilsson, M, Åman, P, Härkönen, H, Hallmans, G, Bach Knudsen, KE, Mazur, W, Adlercreutz, H (1997a) Content of nutrients and lignans in roller milled fractions of rye. Journal of the Science of Food and Agriculture 73, 143–148.3.0.CO;2-H>CrossRefGoogle Scholar
Nilsson, M, Åman, P, Härkönen, H, Hallmans, G, Bach Knudsen, KE, Mazur, W, Adlercreutz, H (1997b) Nutrient and lignan content, dough properties and baking performance of rye samples used in Scandinavia. Acta Agriculturae Scandinavica 47, 26–34.Google Scholar
Normén, AL, Brants, HA, Voorrips, LE, Andersson, HA, van denBrandt, PA & Goldbohm, RA (2001) Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. American Journal of Clinical Nutrition 74, 141–148.CrossRefGoogle ScholarPubMed
Nygren, C, Hallmans, G & Lithner, F (1981) Long term effects of dietary fibre in bread on weight, blood glucose, glucosuria and faecal fat excretion in alloxan diabetic rats. Diabete et Metabolisme 7, 115–120.Google ScholarPubMed
Nygren, C, Hallmans, G & Lithner, F (1984) Effect of high-bran bread on blood glucose control in insulin-dependent diabetic patients. Diabete et Metabolisme 10, 39–43.Google ScholarPubMed
Oishi, K, Okada, K, Yoshida, O, Yamabe, H & Ohno, Y (1988) A casecontrol study of prostatic cancer with reference to dietary habit. Prostate 12, 179–190.CrossRefGoogle Scholar
Pereira, MA, Jacobs, DR Jr, Pins, JJ, Raatz, KS, Gross, MD, Slavin, JL & Seaquist, ER (2002) Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. American Journal of Clinical Nutrition 75, 848–855.CrossRefGoogle ScholarPubMed
Pettersson, D, Åman, P, Bach, Knudsen, KE, Lundin, E, Zhang, JX, Hallmans, G, Härkönen, H Adlercreutz, H (1996) Intake of rye bread by ileostomists increases ileal excretion of fiber polysaccharide components and organic acids but does not increase plasma or urine lignans and isoflavonoids. Journal of Nutrition 126, 1594–1600.CrossRefGoogle ScholarPubMed
Pietinen, P, Malila, N, Virtanen, M, Hartman, TJ, Tangrea, JA, Albanes, D & Virtamo, J (1999) Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes and Control 10, 387–396.CrossRefGoogle Scholar
Pietinen, P, Rimm, EB, Korhonen, P, Hartman, AM, Willett, WC, Albanes, D & Virtamo, J (1996) Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. Circulation 94, 2720–2727.CrossRefGoogle Scholar
Pietinen, P, Stumpf, K, Mannisto, S, Kataja, V, Uusitupa, M & Adlercreutz, H (2001) Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiology, Biomarkers and Prevention 10, 339–344.Google ScholarPubMed
Pukkala, E, Gustavsson, N & Teppom, L (1987) Atlas of Cancer Incidence in Finland, p. 37 Helsinki, Finland: Offset/PKK OyGoogle Scholar
Riboli, E & Kaaks, R (1997) The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition. International Journal of Epidemiology 26, S6–S14. Suppl. 1CrossRefGoogle ScholarPubMed
Ross, AB, Kamal-Eldin, A, Åman, P, Lundin, E, Zhang, JX & Hallmans, G (2001) Alkylresorcinols are absorbed by humans Whole Grain and Human Health. Proceedings of International Symposium, VTT 213, Espoo, Finland, p. 93 [Liukkonen, K, Kuokka, A and Poutanen, K, editor] Espoo, Finland: VTTGoogle Scholar
Rowland, IR, Wiseman, H, Sanders, TA, Adlercreutz, H & Bowey, EA (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutrition and Cancer 36, 27–32.CrossRefGoogle ScholarPubMed
Salmeron, J, Manson, JAE, Stampfer, MJ, Golditz, GA, Wing, AL & Willett, WC (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. Journal of the American Medical Association 277, 472–477.CrossRefGoogle ScholarPubMed
Sandman, PO, Adolfsson, R, Hallmans, G, Nygren, C, Nystrom, L & Winblad, B (1983) Treatment of constipation with high-bran bread in long-term care of severely demented elderly patients. Journal of the American Geriatrics Society 31, 289–293.CrossRefGoogle ScholarPubMed
Schatzkin, A, Lanza, E, Corle, D, Lance, P, Iber, F, Caan, B, Shike, M, Weissfeld, J, Burt, R, Cooper, MR, Kikendall, JW & Cahill, J (2000) Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. New England Journal of Medicine 342, 1149–1155.CrossRefGoogle ScholarPubMed
Severson, R, Nomura, A, Grove, J & Stemmermann, G (1989) A prospective study of demographies, diets and prostatic cancer among man of Japanese ancestry in Hawaii. Cancer Research 49, 1857–1860.Google Scholar
Stattin, P, Adlercreutz, H, Tenkanen, L, Jellum, E, Lumme, S, Hallmans, G, Harvei, S, Teppo, L, Stumpf, K, Luostarinen, T, Lehtinen, M, Dillner, J & Hakama, M (2002) Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study. International Journal of Cancer 99, 124–129.CrossRefGoogle Scholar
Strom, SS, Yamamura, Y, Duphrone, CM, Spitz, MR, Babaian, RJ, Pillow, PC & Hursting, SD (1999) Phytoestrogen intake and prostate cancer: A case-control study using a new data base. Nutrition and Cancer 33, 20–25.CrossRefGoogle Scholar
Stumpf, K, Pietinen, P, Puska, P & Adlercreutz, H (2000) Changes in serum enterolactone, genistein, and daidzein in a dietary intervention study in Finland. Cancer Epidemiology Biomarkers and Prevention 9, 1369–1372.Google Scholar
Terry, P, Giovannucci, E, Michels, KB, Bergkvist, L, Hansen, H, Holmberg, L & Wolk, A (2001a) Fruit, vegetables, dietary fiber, and risk of colorectal cancer. Journal of the National Cancer Institute 93, 525–533.CrossRefGoogle ScholarPubMed
Terry, P, Lagergren, J, Ye, W, Wolk, A & Nyren, O (2001b) Inverse association between intake of cereal fiber and risk of gastric cardia cancer. Gastroenterology 120, 387–391.CrossRefGoogle ScholarPubMed
Thompson, LU (1995) Flaxseed, lignans, and cancer Flaxseed in Human Nutrition, pp.219–236 [Cunnane, SC and Thompson, LU, editors]. Champaign, IL: AOCS PressGoogle Scholar
Truswell, AS (2002) Cereal grains and coronary heart disease. European Journal of Clinical Nutrition 56, 1–14.CrossRefGoogle ScholarPubMed
Vanharanta, M, Voutilainen, S, Lakka, TA, van der Lee, M, Adlercreutz, H, Salonen, JT (1999) Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet 354, 2112–2115.CrossRefGoogle ScholarPubMed
Vanharanta, M, Voutilainen, S, Nurmi, T, Kaikkonen, J, Roberts, LJ, Morrow, JD, Adlercreutz, H & Salonen, JT (2002) Association between low serum enterolactone and increased plasma F2–isoprostanens, a measure of lipid peroxidation. Atherosclerosis 160, 465–469.CrossRefGoogle ScholarPubMed
Willett, WC (1998) The Dietary Pyramid: does the foundation need repair?. American Journal of Clinical Nutrition 68, 218–219.CrossRefGoogle ScholarPubMed
Wolk, A, Manson, JE, Stampfer, MJ, Colditz, GA, Hu, FB, Speizer, FE, Hennekens, CH & Willett, WC (1999) Long-term intake of dietary fiber and decreased risk of coronary heart disease among women. Journal of the American Medical Association 281, 1998–2004.CrossRefGoogle ScholarPubMed
World Cancer Research Fund and the American Institute for Cancer Research (1997) Food, Nutrition and The Prevention. of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer ResearchGoogle Scholar
Zheng, W, Dai, Q, Custer, LJ, Shu, XO, Wen, WQ, Jin, F & Franke, AA (1999) Urinary excretion of isoflavonoids and the risk of breast cancer. Cancer Epidemiology, Biomarkers and Prevention 8, 35–40.Google ScholarPubMed