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The roles of vitamins D and K in bone health and osteoporosis prevention

Published online by Cambridge University Press:  28 February 2007

M. J. Shearer
Affiliation:
The Vitamin K Research Unit, The Haemophilia Centre, St Thomas's Hospital, Lumbeth Palace Road, London SEI 7EH
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Abstract

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Type
Symposium on ‘Nutritional aspects of bone’
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Akiyama, Y., Hara, K., Tajima, T., Murota, S. & Morita, I. (1994). Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures. European Journal of Pharmacology 263, 181185.CrossRefGoogle ScholarPubMed
Balsan, S., Garabedian, M. & Lavchet, M. (1986). Long term nocturnal calcium infusions can cure rickets and promote normal mineralization in hereditary resistance to 1,25-dihydroxyvitamin D3. Journal of Clinical Investigation 77, 16611667.CrossRefGoogle Scholar
Barragry, J. M., France, M. W., Corless, D., Gupta, S. P., Switala, S., Boucher, B. J. & Cohen, R. D. (1978). Intestinal cholecalciferol absorption in the elderly and in younger adults. Clinical Science and Molecular Medicine 55, 213220.Google ScholarPubMed
Bikle, D. D. (1994). Role of vitamin D, its metabolites and analogs in the management of osteoporosis. Rheumatic Disease Clinics of North America 20, 759775.CrossRefGoogle ScholarPubMed
Binkley, N. C. & Suttie, J. W. (1995). Vitamin K nutrition and osteoporosis. Journal of Nutrition 125, 18121821.CrossRefGoogle ScholarPubMed
Blumsohn, A., Hannon, R. A. & Eastell, R. (1995). Apparent instability of osteocalcin in serum as measured with different commercially available immunoassays. Clinical Chemistry 41, 318322.CrossRefGoogle ScholarPubMed
Booth, S. L., Pennington, J. A. T. & Sadowski, J. A. (1996). Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study. Journal of the American Dietetic Association 96, 149154.CrossRefGoogle ScholarPubMed
Booth, S. L., Sadowski, J. A. & Pennington, J. A. T. (1995 a). Phylloquinone (vitamin K1) content of foods in the U.S. Food and Drug Administration's Total Diet Study. Journal of Agricultural and Food Chemistry 43, 15741579.CrossRefGoogle Scholar
Booth, S. L., Sokoll, L. J., O'Brien, M. E., Tucker, K., Dawson-Hughes, B., & Sadowski, J. A. (1995 b). Assessment of dietary phylloquinone intake and vitamin K status in postmenopausal women. European Journal of Clinical Nutrition 49, 832841.Google ScholarPubMed
Bouillon, R. (1990). Clinical use of vitamin D metabolite assays (calcidol and calcitriol). In Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP: Assays and their Clinical Application, pp. 2447 [Schmidt-Gayk, H, Armbruster, F. P. and Bouillon, R., editors]. Berlin: Springer–Verlag.CrossRefGoogle Scholar
Cairns, J. R. & Price, P. A. (1994). Direct demonstration that the vitamin K-dependent bone Gla protein is incompletely γ-carboxylated in humans. Journal of Bone and Mineral Research 9, 19891997.CrossRefGoogle ScholarPubMed
Chapuy, M.-C., Arlot, M. E., Delmas, P. D. & Meunier, P. J. (1994). Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. British Medical Journal 308, 10811082.CrossRefGoogle ScholarPubMed
Chapuy, M.-C., Arlot, M. E., Duboeuf, F., Brun, J., Crouzet, B., Arnaud, S., Delmas, P. D. & Meunier, P. J. (1992). Vitamin D3 and calcium to prevent hip fractures in elderly women. New England Journal of Medicine 327, 16371642.CrossRefGoogle ScholarPubMed
Chapuy, M.-C., Chapuy, P. & Meunier, P. J. (1987). Calcium and vitamin D suplements: effects on calcium metabolism in elderly people. American Journal of Clinical Nutrition 46, 324328.CrossRefGoogle Scholar
Chenu, C., Colucci, S., Grano, M., Zigrino, P., Barattolo, R., Zambonin, G., Baldini, N., Vergnaud, P., Delmas, P. D. & Zallone, A. Z. (1994). Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells. Journal of Cell Biology 127, 11491158.CrossRefGoogle ScholarPubMed
Compston, J. E. (1995). The role of vitamin D and calcium supplementation in the prevention of osteoporotic fractures in the elderly. Clinical Endocrinology 43, 393405.CrossRefGoogle ScholarPubMed
Conly, J. M. & Stein, K. (1992). Quantitative and qualitative measurements of K vitamins in human intestinal contents. American Journal of Gastroenterology 87, 311316.Google ScholarPubMed
Dawson-Hughes, B. (1996). Calcium, vitamin D and vitamin D metabolites. In Osteoporosis 1996: Proceedings of the 1996 World Congress on Osteoporosis Amsterdam, The Netherlands, 18–23 05, 1996, pp. 299303 [Papapoulos, S.E., Lips, P., Pols, P., Johnston, C. C. and Delmas, P. D., editors]. Amsterdam: Elsevier.Google Scholar
Dawson-Hughes, B., Dallal, G. E., Krall, E. A., Harris, S., Sokoll, L. J. & Falconer, G. (1991). Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Annals of Internal Medicine 115, 505512.CrossRefGoogle ScholarPubMed
Dawson-Hughes, B., Harris, S. S., Krall, E. A., Dallal, G. E., Falconer, G. & Green, C. L. (1995). Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. American Journal of Clinical Nutrition 61, 11401145.CrossRefGoogle ScholarPubMed
Department of Health (1991). Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: H.M. Stationery Office.Google Scholar
Dowd, P., Hershline, R., Ham, S. W. & Naganathan, S. (1995). Vitamin K and energy transduction: a base strength amplification mechanism. Science 269, 16841691.CrossRefGoogle ScholarPubMed
Ducy, P., Desbois, C., Boyce, B., Pinero, G., Story, B., Dunstan, C., Smith, E., Bonadio, J., Goldstein, S., Gundberg, C., Bradley, A. & Karsenty, G. (1996). Increased bone formation in osteocalcin-deficient mice. Nature 382, 448452.CrossRefGoogle ScholarPubMed
Eastell, R., Yergey, A. L., Vieira, N. E., Cedel, S. L., Kumar, R. & Riggs, B. L. (1991). Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function, and age in women: evidence of an age-related intestinal resistance to 1, 25-dihydroxyvitamin D action. Journal of Bone and Mineral Research 6, 125132.CrossRefGoogle ScholarPubMed
Ebeling, P. R., Sandgren, M. E., DiMagno, E. P., Lane, A. W., DeLuca, H. F. & Riggs, B. L. (1992). Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. Journal of Clinical Endocrinology and Metabolism 75, 176182.Google ScholarPubMed
Feldman, D., Malloy, P. J. & Gross, C. (1996). Vitamin D: metabolism and action. In Osteoporosis, pp. 205235 [Marcus, R., Feldman, D. and Kelsey, J., editors]. San Diego: Academic Press.Google Scholar
Ferland, G., Sadowski, J. A. & O'Brien, M. E. (1993). Dietary induced subclinical vitamin K deficiency in normal human subjects. Journal of Clinical Investigation 91, 17611768.CrossRefGoogle ScholarPubMed
Fujita, T. (1992). Vitamin D in the treatment of osteoporosis. Proceedings of the Society for Experimental Biology and Medicine 199, 394399.CrossRefGoogle ScholarPubMed
Fujita, T. (1996). Vitamin D in the treatment of osteoporosis revisited. Proceedings of the Society for Experimental Biology and Medicine 212, 110115.CrossRefGoogle ScholarPubMed
Furie, B. & Furie, B. C. (1990). Molecular basis of vitamin K-dependent γ-carboxylation. Blood 75, 17531762.CrossRefGoogle ScholarPubMed
Glowacki, J., Rey, C., Glimcher, M. J., Cox, K. A. & Lian, J. (1991). A role for osteocalcin in osteoclast differentiation. Journal of Cellular Biochemistry 45, 292302.CrossRefGoogle ScholarPubMed
Hannah, S. S. & Norman, A. W. (1994). 1α,25 (OH)2 Vitamin D3-regulated expression of the eukaryotic genome. Nutrition Reviews 52, 376382.CrossRefGoogle Scholar
Hara, K., Akiyama, Y., Nakamura, T., Murota, S. & Morita, I. (1995). The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. Bone 16, 179184.CrossRefGoogle Scholar
Hara, K., Akiyama, Y., Tajima, T. & Shiraki, M. (1993). Menatetrenone inhibits bone resorption partly through inhibition of PGE2 synthesis in vitro. Journal of Bone and Mineral Research 8, 535542.CrossRefGoogle ScholarPubMed
Hart, J. P., Shearer, M. J., Klenerman, L., Catterall, A., Reeve, J., Sambrook, P. N., Dodds, R. A., Bitensky, L. & Chayen, J. (1985). Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. Journal of Clinical Endocrinology and Metabolism 60, 12681269.CrossRefGoogle ScholarPubMed
Hauschka, P. V. & Carr, S. A. (1982). Calcium-dependent α-helical structure in osteocalcin. Biochemistry 21, 25382547.CrossRefGoogle ScholarPubMed
Hauschka, P. V., Lian, J. B. & Gallop, P. M. (1975). Direct identification of the calcium-binding amino acid, γ-carboxyglutamate, in mineralized tissue. Proceedings of the National Academy of Sciences USA 72, 39253929.CrossRefGoogle ScholarPubMed
Heaney, R. P. (1996). Nutrition and risk for osteoporosis. In Osteoporosis, pp. 483509 [Marcus, R., Feldman, D. and Kelsey, J., editors]. San Diego: Academic Press.Google ScholarPubMed
Hegarty, V., Woodhouse, P. & Khaw, K.-T. (1994). Seasonal variation in 25-hydroxyvitamin D and parathyroid hormone concentrations in healthy elderly people. Age and Ageing 23, 478482.CrossRefGoogle ScholarPubMed
Heikinheimo, R. J., Inkovaara, J. A., Harju, E. J., Haavisto, M. V., Kaarela, R. H., Kataja, J. M., Kokko, A. M. L., Kolho, L. A. & Rajala, S. A. (1992). Annual injection of vitamin D and fractures of aged bones. Calcified Tissue International 51, 105110.CrossRefGoogle ScholarPubMed
Himmelstein, S., Clemens, T. L., Rubin, A. & Lindsay, R. (1990). Vitamin D supplementation in elderly nursing home residents increases 25(OH)D but not 1,25(OH)2D. American Journal of Clinical Nutrition 52, 701706.CrossRefGoogle ScholarPubMed
Hodges, S. J., Akesson, K., Vergnaud, P., Obrant, K. & Delmas, P. D. (1993 a). Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. Journal of Bone and Mineral Research 8, 12411245.CrossRefGoogle ScholarPubMed
Hodges, S. J., Bejui, J., Leclercq, M. & Delmas, P. D. (1993 b). Detection and measurement of vitamins K1 and K2 in human cortical and trabecular bone. Journal of Bone and Mineral Research 8, 10051008.CrossRefGoogle ScholarPubMed
Hodges, S. J., Pilkington, M. J., Shearer, M. J., Bitensky, L. & Chayen, J. (1990). Age-related changes in the circulating levels of congeners of vitamin K2, menaquinone-7 and menaquinone-8. Clinical Science 78, 6366.CrossRefGoogle ScholarPubMed
Hodges, S. J., Pilkington, M. J., Stamp, T. C. B., Catterall, A., Shearer, M. J., Bitensky, L. & Chayen, J. (1991). Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck. Bone 12, 387389.CrossRefGoogle ScholarPubMed
Holick, M. F. (1995). Environmental factors that influence the cutaneous production of vitamin D. American Journal of Clinical Nutrition 61, 638S645S.CrossRefGoogle ScholarPubMed
Holick, M. F. (1996). Vitamin D and bone health. Journal of Nutrition 126, 1159S1164S.CrossRefGoogle ScholarPubMed
Holick, M. F., Matsuoka, L. Y. & Wortsman, J. (1989). Age, vitamin D and solar ultraviolet. Lancet ii, 11041105.CrossRefGoogle Scholar
Houston, L. A., Grant, S. F. A., Reid, D. M. & Ralston, S. H. (1996). Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population. Bone 18, 249252.CrossRefGoogle Scholar
Ichihashi, T., Takagishi, Y., Uchida, K. & Yamada, H. (1992). Colonic absorption of menaquinone-4 and menaquinone-9 in rats. Journal of Nutrition 122, 506512.CrossRefGoogle ScholarPubMed
Kameda, T., Miyazawa, K., Mori, Y., Yuasa, T., Shiokawa, M., Nakamaru, Y., Mano, H., Hakeda, Y., Kameda, A. & Kumegawa, M. (1996). Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochemical and Biophysical Research Communications 220, 515519.CrossRefGoogle ScholarPubMed
Khaw, K.-T., Sneyd, M.-J. & Compston, J. (1992). Bone density parathyroid hormone and 25-hydroxyvitamin D concentrations in middle aged women. British Medical Journal 305, 273277.CrossRefGoogle ScholarPubMed
Knapen, M. H. J., Hamulyák, K. & Vermeer, C. (1989). The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion. Annals of Internal Medicine 111, 10011005.CrossRefGoogle ScholarPubMed
Knapen, M. H. J., Jie, K.-S. G., Hamulyák, K. & Vermeer, C. (1993). Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss. Calcified Tissue International 53, 8185.CrossRefGoogle ScholarPubMed
Kohlmeier, M., Salomon, A., Saupe, J. & Shearer, M. J. (1996). Transport of vitamin K to bone in humans. Journal of Nutrition 126, 1192S1196S.CrossRefGoogle ScholarPubMed
Kohlmeier, M., Saupe, J., Drossel, H.-J. & Shearer, M. J. (1995). Variation of phylloquinone (vitamin K1) concentrations in hemodialysis patients. Thrombosis and Haemostasis 74, 12521254.Google ScholarPubMed
Krall, E. A., Sahyoun, N., Tannenbaum, S., Dallal, G. E. & Dawson-Hughes, B. (1989). Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. New England Journal of Medicine 321, 17771783.CrossRefGoogle ScholarPubMed
Lian, J. B. & Gundberg, C. M. (1988). Osteocalcin: biochemical considerations and clinical applications. In Clinical Orthopaedics and Related Research no. 266, pp. 267291 [Urist, M. R., editor]. Philadelphia: J. P. Lippincott Company.Google Scholar
Lian, J. B. & Stein, G. S. (1996). Osteoclast biology. In Osteoporosis, pp. 2359 [Marcus, R., Feldman, D. and Kelsey, J., editors]. San Diego: Academic Press.Google Scholar
Liggett, W. H. Jr, Lian, J. B., Greenberger, J. S. & Glowacki, J. (1994). Osteocalcin promotes differentiation of osteoclast progenitors from murine long-term bone marrow cultures. Journal of Cellular Biochemistry 55, 190199.CrossRefGoogle ScholarPubMed
Lips, P. (1994). Suboptimal vitamin D status: a risk factor for osteoporosis? Advances in Nutritional Research 9, 151166.Google ScholarPubMed
Lips, P., Graafmans, W. C., Ooms, M. E., Bezemer, P. D. & Bouter, L. M. (1996). Vitamin D supplementation and fracture incidence in elderly persons: a randomized, placebo-controlled clinical trial. Annals of Internal Medicine 124, 400406.CrossRefGoogle Scholar
Lips, P., Wiersinga, A., van Ginkel, F. C., Jongen, M. J. M., Netelenbos, J. C., Hackeng, W. H. L., Delmas, P. D. & van der Vijgh, W. J. F. (1988). The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. Journal of Clinical Endocrinology and Metabolism 67, 644–450.CrossRefGoogle ScholarPubMed
Lund, B. & Sørrensen, O. H. (1979). Measurement of 25-hydroxyvitamin D in serum and its relation to sunshine, age and vitamin D intake in the Danish population. Scandinavian Journal of Clinical and Laboratory Investigation 39, 2330.CrossRefGoogle Scholar
Luo, G., Ducy, P., McKee, M. D., Pinero, G. J., Loyer, E., Behringer, R. R. & Karsenty, G. (1997). Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386, 7881.CrossRefGoogle ScholarPubMed
MacLaughlin, J. & Holick, M. F. (1985). Ageing decreases the capacity of human skin to produce vitamin D3. Journal of Clinical Investigation 76, 15361538.CrossRefGoogle ScholarPubMed
Marcus, R. (1996). The nature of osteoporosis. In Osteoporosis, pp. 647659 [Marcus, R., Feldman, D. and Kelsey, J., editors]. San Diego: Academic Press.Google ScholarPubMed
Merle, B. & Delmas, P. D. (1990). Normal carboxylation of circulating osteocalcin (Bone Gla protein) in Paget's disease of bone. Bone and Mineral 11, 237245.CrossRefGoogle ScholarPubMed
Ministry of Agriculture, Fisheries and Food (1994). Dietary and Nutritional Survey of British Adults: Further Analysis. London: H.M. Stationery Office.Google Scholar
Murphy, S., Khaw, K.-T., Prentice, A. & Compston, J. E. (1993). Relationships between parathyroid hormone, 25-hydroxyvitamin D, and bone mineral density in elderly men. Age and Ageing 22, 198204.CrossRefGoogle ScholarPubMed
National Research Council (1989). Recommended Dietary Allowances, 10th ed. Washington, DC: National Academy Press.Google Scholar
Ooms, M. E., Roos, J. C., Bezemer, P. D., Van der Vijgh, W. J. F., Bouter, L. M. & Lips, P. (1995). Prevention of bone loss by vitamin D supplementation in elderly women: a randomised double-blind trial. Journal of Clinical Endocrinology and Metabolism 80, 10521058.Google Scholar
Parfitt, A. M., Gallagher, J. C., Heaney, R. P., Johnston, C. C., Neer, R. & Whedon, G. D. (1982). Vitamin D and bone health in the elderly. American Journal of Clinical Nutrition 36, 10141031.CrossRefGoogle ScholarPubMed
Plantalech, L., Guillaumont, M., Vergnaud, P., Leclercq, M. & Delmas, P.D. (1991). Impairment of gamma carboxylation of circulating osteocalcin (bone gla protein) in elderly women. Journal of Bone and Mineral Research 6, 12111216.CrossRefGoogle ScholarPubMed
Prentice, A. (1997). Is nutrition important in osteoporosis? Proceedings of the Nutrition Society 56, 357367.CrossRefGoogle ScholarPubMed
Price, P. A. (1985). Vitamin K-dependent formation of bone Gla protein (osteocalcin) and its function. Vitamins and Hormones 42, 65108.CrossRefGoogle ScholarPubMed
Price, P. A. & Baukol, S. A. (1980). 1,25-dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells. Journal of Biological Chemistry 255, 1166011663.CrossRefGoogle ScholarPubMed
Price, P. A. & Baukol, S. A. (1981). 1,25-Dihyroxyvitamin D3 increases serum levels of the vitamin K-dependent bone protein. Biochemical and Biophysical Research Communications 99, 928935.CrossRefGoogle Scholar
Price, P. A. & Kaneda, Y. (1987). Vitamin K counteracts the effect of warfarin in liver but not in bone. Thrombosis Research 46. 121131.CrossRefGoogle Scholar
Price, P. A., Poser, J. W. & Raman, N. (1976). Primary structure of the γ-carboxyglutamic acid-containing protein from bovine bone. Proceedings of the National Academy of Sciences USA 73, 33743375.CrossRefGoogle ScholarPubMed
Price, R., Fenton, S., Shearer, M. J. & Bolton-Smith, C. (1996). Daily and seasonal variation in phylloquinone (vitamin K1) intake in Scotland. Proceedings of the Nutrition Society 55, 244A.Google Scholar
Reid, I. R. (1996). Vitamin D and its metabolites in the management of osteoporosis. In Osteoporosis, pp. 11691190 [Marcus, R., Feldman, D. and Kelsey, J., editors]. San Diego: Academic Press.Google ScholarPubMed
Reid, I. R., Gallagher, D. J. A. & Bosworth, J. (1986). Prophylaxis against vitamin D deficiency in the elderly by regular sunlight exposure. Age and Ageing 15, 3540.CrossRefGoogle ScholarPubMed
Robey, P. G. & Boskey, A. L. (1996). The biochemistry of bone. In Osteoporosis, pp. 95183 [Marcus, R., Feldman, D. and Kelsey, J., editors]. San Diego: Academic Press.Google Scholar
Rosen, C. J., Morrison, A., Zhou, H., Storm, D., Hunter, S. J., Musgrave, K., Chen, T., Wei, W. & Holick, M. F. (1994). Elderly women in northern New England exhibit seasonal changes in bone mineral density and calciotropic hormones. Bone and Mineral 25, 8392.CrossRefGoogle ScholarPubMed
Sadowski, J. A., Hood, S. J., Dallal, G. E. & Gany, P. J. (1989). Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. American Journal of Clinical Nutrition 50, 100108.CrossRefGoogle Scholar
Shearer, M. J. (1995). Vitamin K: its physiological role and the assessment of clinical and subclinical deficiency states. Journal of the International Federation of Clinical Chemistry 7, 8895.Google Scholar
Shearer, M. J., Bach, A. & Kohlmeier, M. (1996). Chemistry, nutritional sources tissue distribution and metabolism of vitamin K with special reference to bone health. Journal of Nutrition 126 1181S1186S.CrossRefGoogle ScholarPubMed
Silverberg, S. J., Fitzpatrick, L. A. & Bilezikian, J. P. (1996). The role of parathyroid hormone and vitamin D in the pathogenesis of osteoporosis. In Osteoporosis, pp. 715726 [Marcus, R., Feldman, D. and Kelsey, J., editors]. San Diego: Academic Press.Google Scholar
Slovik, D. M., Adams, J. S., Neer, R. M., Holick, M. F. & Potts, J. T. Jr (1981). Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients. New England Journal of Medicine 305, 372374.CrossRefGoogle Scholar
Sokoll, L. J., Booth, S. L., O'Brien, M. E., Davidson, K. W., Tsaioun, K. I. & Sadowski, J. A. (1997). Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma;-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. American Journal of Clinical Nutrition 65, 779784.CrossRefGoogle ScholarPubMed
Sokoll, L. J., O'Brien, M. E., Camilo, M. E. & Sadowski, J. A. (1995). Undercarboxylated osteocalcin and development of a method to determine vitamin K status. Clinical Chemistry 41, 11211128.CrossRefGoogle ScholarPubMed
Sokoll, L. J. & Sadowski, J. A. (1996). Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. American Journal of Clinical Nutrition 63, 566573.CrossRefGoogle Scholar
Suda, T., Takahashi, N. & Martin, T. J. (1992). Modulation of osteoclast differentiation. Endocrine Reviews 13, 6680.Google ScholarPubMed
Suttie, J. W. (1995). The importance of menaquinones in human nutrition. Annual Review of Nutrition 15, 399417.CrossRefGoogle ScholarPubMed
Suttie, J. W., Mummah-Schendel, L. L., Shah, D. V., Lyle, B. J. & Greger, J. L. (1988). Vitamin K deficiency from dietary vitamin K restriction in humans. American Journal of Clinical Nutrition 47, 475480.CrossRefGoogle ScholarPubMed
Szulc, P., Arlot, M., Chapuy, M.-C., Duboeuf, F., Meunier, P. J. & Delmas, P. D. (1994). Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. Journal of Bone and Mineral Research 9, 15911595.CrossRefGoogle ScholarPubMed
Szulc, P., Chapuy, M.-C., Meunier, P. J. & Delmas, P. D. (1993). Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. Journal of Clinical Investigation 91, 17691774.CrossRefGoogle ScholarPubMed
Teitelbaum, S. L., Tondravi, M. M. & Ross, F. P. (1996). Osteoclast biology. In Osteoporosis, pp. 6194 [Marcus, R., Feldman, D. and Kelsey, J., editors]. San Diego: Academic Press.Google ScholarPubMed
Thijssen, H. H. W. & Drittij-Reijnders, M. J. (1994). Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. British Journal of Nutrition 72, 415425.CrossRefGoogle ScholarPubMed
Tsai, K.-S., Heath, H. IIL, Kumar, R. & Riggs, B. L. (1984). Impaired vitamin D metabolism with aging in women. Journal of Clinical Investigation 73, 16681672.CrossRefGoogle ScholarPubMed
Usui, Y., Tanimura, H., Nishimura, N., Kobayashi, N., Okanoue, T. & Ozawa, K. (1990). Vitamin K concentrations in the plasma and liver of surgical patients. American Journal of Clinical Nutrition 51, 846852.CrossRefGoogle ScholarPubMed
Vergnaud, P., Garnero, P., Meunier, P. J., Bréart, G., Kamihagi, K. & Delmas, P. D. (1997). Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS study. Journal of Clinical Endocrinology and Metabolism 82, 719724.Google ScholarPubMed
Vermeer, C., Jie, K.-S. G. & Knapen, M. H. J. (1995). Role of vitamin K in bone metabolism. Annual Review of Nutrition 15, 1–22.CrossRefGoogle ScholarPubMed
Widdershoven, J., van Munster, P., De Abreu, R., Bosman, H., van Lith, Th., van der Putten-van Mevel, M., Motohara, K. & Matsuda, I. (1987). Four methods compared for measuring des-carboxy-prothornbin (PIVKA-11). Clinical Chemistry 33, 20742078.CrossRefGoogle Scholar