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Recent advances in the nutritional biochemistry of trivalent chromium

Published online by Cambridge University Press:  07 March 2007

John B. Vincent
John B. Vincent*
Affiliation:
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487-0336, USA
*
Corresponding author: Professor John B. Vincent, fax +1 205 348 9203, email [email protected]
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Abstract

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The nutritional biochemistry of trivalent Cr has been a poorly understood field of study; investigations of the biochemistry of the other essential transition metals have not proven as problematic. Despite over four decades of endeavour, only recently has a picture of the role of Cr potentially started to be defined. The biologically-relevant form is the trivalent ion. Cr3+ appears to be required for proper carbohydrate and lipid metabolism in mammals, although fortunately Cr deficiency is difficult to achieve. Conditions that increase circulating glucose and insulin concentrations increase urinary Cr output. Cr is probably excreted in the form of the oligopeptide chromodulin. Chromodulin may be the key to understanding the role of Cr at a molecular level, as the molecule has been found to bind to activated insulin receptor, stimulating its kinase activity. A mechanism for the action of chromodulin has recently been proposed; this mechanism can serve as a potential framework for further studies to test the role of Cr in metabolism. An examination of the nutritional supplement chromium picolinate illustrates some of the difficulties associated with these biochemical studies.

Keywords

ChromiumChromodulinChromium picolinate
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 1 , February 2004 , pp. 41 - 47
Copyright
Copyright © The Nutrition Society 2004

References

Althuis, MD, Jordan, NE, Ludington, EA & Wittes, JT (2002) Glucose and insulin responses to dietary chromium supplements: a meta-analysis. American Journal of Clinical Nutrition 76, 148–155.CrossRefGoogle ScholarPubMed
Anderson, RA (1998) Chromium, glucose tolerance and diabetes. Journal of the American College of Nutrition 17, 548–555.CrossRefGoogle Scholar
Anderson, RA (2000) Chromium in the prevention and control of diabetes. Diabetes Metabolism (Paris) 26, 22–27.Google ScholarPubMed
Anderson, RA, Bryden, NA & Polansky, MM, (1993) Dietary intake of calcium, chromium, copper, iron, magnesium, manganese and zinc: duplicate plate values corrected using nutrient intake. Journal of the American Dietetic Association 93, 462–464.CrossRefGoogle ScholarPubMed
Anderson, RA, Bryden, NA & Polansky, MM, (1997a) Lack of toxicity of chromium chloride and chromium picolinate in rats. Journal of the American College of Nutrition 16, 273–279.CrossRefGoogle Scholar
Anderson, RA, Bryden, NA, Polansky, MM & Reisner, S (1990) Urinary chromium excretion and insulinogenic properties of carbohydrates. American Journal of Clinical Nutrition 51, 864–868.CrossRefGoogle ScholarPubMed
Anderson, RA, Cheng, NC, Bryden, NA, Polansky, MM, Cheng, N, Chi, J & Feng, J (1997b) Elevated levels of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 46, 1786–1791.CrossRefGoogle ScholarPubMed
Anderson, RA & Kozlovsky, AS (1985) Chromium intake, absorption and excretion of subjects consuming self-selected diets. American Journal of Clinical Nutrition 41, 1177–1183.CrossRefGoogle ScholarPubMed
Anderson, RA & Polansky, MM (1995) Dietary and metabolite effects on trivalent chromium retention and distribution in rats. Biological Trace Element Research 50, 97–108.CrossRefGoogle ScholarPubMed
Bagchi, D, Bagchi, M, Balmoori, J, Ye, X & Stohs, SJ (1997) Comparative induction of oxidative stress in cultured J774A.1 macrophage cells by chromium picolinate and chromium nicotinate. Research Communications in Molecular Pathology and Pharmacology 97, 335–346.Google ScholarPubMed
Bagchi, D, Stohs, SJ, Downs, BW, Bagchi, M & Preuss, HG (2002) Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology 180, 5–22.CrossRefGoogle ScholarPubMed
Bunker, VW, Lawson, MS, Delues, HT & Clayton, BE (1984) The uptake and excretion of chromium by the elderly. American Journal of Clinical Nutrition 39, 797–802.CrossRefGoogle ScholarPubMed
Cefalu, WT, Wang, ZQ, Zhang, XH, Baldor, LC & Russell, JC (2002) Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats. Journal of Nutrition 132, 1107–1114.CrossRefGoogle ScholarPubMed
Cerulli, J, Grabe, DW, Gauthier, I, Malone, M & McGoldrick, MD (1998) Chromium picolinate toxicity. Annals of Pharmacotherapy 32, 428–431.CrossRefGoogle ScholarPubMed
Cheng, N, Zhu, X, Shi, H, Wu, W, Chi, J, Cheng, J & Anderson, RA (1999) Follow-up survey of people in China with type 2 diabetes mellitus consuming supplemental chromium. Journal of Trace Elements in Experimental Research 12, 55–60.3.0.CO;2-G>CrossRefGoogle Scholar
Clarkson, PM (1997) Effects of exercise on chromium levels: is supplementation required?. Sports Medicine 23, 341–349.CrossRefGoogle ScholarPubMed
Clodfelder, BJ, Emamaullee, J, Hepburn, DD, Chakov, NE, Nettles, H & Vincent, JB (2001) The trail of chromium(III) from the blood to the urine: the roles of transferrin and chromodulin. Journal of Biological Inorganic Chemistry 6, 608–617.CrossRefGoogle Scholar
Davis, CM, Royer, AC & Vincent, JB (1997) Synthetic multinuclear chromium assembly activates insulin receptor kinase activity: functional model for low-molecular-weight chromium-binding substance. Inorganic Chemistry 36, 5316–5320.CrossRefGoogle Scholar
Davis, CM, Sumrall, KH & Vincent, JB (1996) The biologically active form of chromium may activate a membrane phosphotyrosine phosphatase (PTP). Biochemistry 35, 12963–12969.CrossRefGoogle ScholarPubMed
Davis, CM & Vincent, JB (1997a) Chromium oligopeptide activates insulin receptor tyrosine kinase activity. Biochemistry 36, 4382–4385.CrossRefGoogle ScholarPubMed
Davis, CM & Vincent, JB (1997b) Isolation and characterization of a biologically active chromium oligopeptide from bovine liver. Archives of Biochemistry and Biophysics 339, 335–343.CrossRefGoogle ScholarPubMed
Evans, GW (1989) The effect of chromium picolinate on insulin controlled parameters in humans. International Journal of Biosocial Medicine and Research 11, 163–180.Google Scholar
Fowler, JF Jr (2000) Systemic contact dermatitis caused by oral chromium picolinate. Cutis 65 116.Google ScholarPubMed
Ghosh, D, Bhattacharya, B, Mukherjee, B, Manna, B, Sinha, M, Chowdhury, J & Chowdhury, S (2002) Role of chromium supplementation in Indians with type 2 diabetes mellitus. Journal of Nutritional Biochemistry 13, 690–697.CrossRefGoogle ScholarPubMed
Gibson, RS & Scythes, CA (1984) Chromium, selenium, and other trace element intakes of a selected sample of Canadian premenopausal women. Biological Trace Element Research 6, 105–116.CrossRefGoogle ScholarPubMed
Hellerstein, MK (1998) Is chromium supplementation effective in managing type II diabetes?. Nutrition Reviews 56, 302–306.CrossRefGoogle ScholarPubMed
Hepburn, DDD, Burney, JM, Woski, SA & Vincent, JB (2003a) The nutritional supplement chromium picolinate generates oxidative DNA damage and peroxidized lipids in vivo. Polyhedron 22, 455–463.CrossRefGoogle Scholar
Hepburn, DDD & Vincent, JB (2002) In vivo distribution of chromium from chromium picolinate in rats and implications for the safety of the dietary supplement. Chemical Research in Toxicology 15, 93–100.CrossRefGoogle ScholarPubMed
Hepburn, DDD & Vincent, JB (2003) Tissue and subcellular distribution of chromium picolinate with time after entering the bloodstream. Journal of Inorganic Biochemistry 94, 86–93.CrossRefGoogle ScholarPubMed
Hepburn, DDD, Xiao, J, Bindom, S, Vincent, JB & O'Donnell, J (2003b) Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 100, 3766–3771.CrossRefGoogle ScholarPubMed
Huszonek, J (1993) Over-the-counter chromium picolinate. American Journal of Psychiatry 150 1560.Google ScholarPubMed
Jacquamet, L, Sun, Y, Hatfield, J, Gu, W, Cramer, SP, Crowder, MW, Lorigan, GA, Vincent, JB & Latour, J-M (2003) Characterization of chromodulin by X-ray absorption and electron paramagnetic resonance spectroscopies and magnetic susceptibility measurements. Journal of the American Chemical Society 125, 774–780.CrossRefGoogle ScholarPubMed
Jeejeebhoy, KN (1999) Chromium and parenteral nutrition. Journal of Trace Elements in Experimental Medicine 12, 85–89.3.0.CO;2-Z>CrossRefGoogle Scholar
Johnson, MK, Powell, DB & Cannon, RD (1981) Vibrational spectra of carboxylate complexes-III. Spectrochimica Acta, 37A 995 –1006.CrossRefGoogle Scholar
Jovanovic, L, Gutierrez, M & Peterson, CM (1999) Chromium supplementation for women with gestational diabetes mellitus. Journal of Trace Elements in Experimental Medicine 12, 91–97.3.0.CO;2-X>CrossRefGoogle Scholar
Kareus, SA, Kelley, C, Walton, HS & Sinclair, PC (2001) Release of Cr(III) from Cr(III) picolinate upon metabolic activation. Journal of Hazardous Materials 84B 163–174.CrossRefGoogle Scholar
Kato, I, Vogelman, JH, Dilman, V, Karkoszka, J, Frenkel, K, Durr, NP, Orentreich, N & Toniolo, P (1998) Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil. European Journal of Epidemiology 14, 621–626.CrossRefGoogle ScholarPubMed
Kim, D-S Kim, T-W Park, I-K Kang, J-S & Om, A-S (2002) Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body weight in dexamethasone-treated rats. Metabolism 51, 589–594.CrossRefGoogle ScholarPubMed
Kozlovsky, AS, Moser, PB, Reisner, RA & Anderson, RA (1986) Effects of diets high in simple sugars on urinary chromium losses. Metabolism 35, 515–518.CrossRefGoogle ScholarPubMed
Kreider, RB (1999) Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Medicine 27, 97–110.CrossRefGoogle ScholarPubMed
Lukaski, HC (1999) Chromium as a supplement. Annual Review of Nutrition 19, 279–302.CrossRefGoogle ScholarPubMed
Mahboob, L McNeil, L, Tolliver, T & Ogden, L (2002) Effects of chromium picolinate on antioxidant enzyme levels in rats. Toxicological Sciences 66, Suppl.1, 32.Google Scholar
Manygoats, KR, Yazzie, M & Stearns, DM (2002) Ultrastructural damage in chromium picolinate-treated cells: a TEM study. Journal of Biological Inorganic Chemistry 7, 791–798.CrossRefGoogle Scholar
Martin, WR & Fuller, RE (1998) Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 18, 860–862.CrossRefGoogle ScholarPubMed
Mirasol, F (2000) Chromium picolinate market sees robust growth and high demand. Chemical Market Reporter 257 2000.Google Scholar
Morris, B MacNeil, S, Fraser, R & Gray, T (1995) Increased urine chromium excretion in normal pregnancy. Clinical Chemistry 41, 1544–1545.CrossRefGoogle ScholarPubMed
Morris, BW MacNeil, S, Hardisty, CA, Heller, S, Burgin, C & Gray, TA (1999) Chromium homeostasis in patients with type II (NIDDM) diabetes. Journal of Trace Elements in Medicine and Biology 13, 57–61.CrossRefGoogle ScholarPubMed
Morris, BW, MacNeil, S, Stanley, K & Gray, TA (1993) The inter-relationship between insulin and chromium in hyperinsulinaemic euglycaemic clamps in healthy volunteers. Journal of Endocrinology 139, 339–345.CrossRefGoogle ScholarPubMed
Nielsen, F (1996) Controversial chromium: does the superstar mineral of the Mountebanks receive appropriate attention from clinicians and nutritionists?. Nutrition Today 31, 226–233.CrossRefGoogle Scholar
Nissen, SL & Sharp, RL (2003) Effect of dietary supplements on lean mass and strength gains with resistance exercise: A meta-analysis. Journal of Applied Physiology 94, 651–659.CrossRefGoogle ScholarPubMed
Offenbacher, EG, Spencer, H, Dowling, HJ & Pi-Sunyer, FX (1986) Metabolic chromium balances in men. American Journal of Clinical Nutrition 44, 77–82.CrossRefGoogle ScholarPubMed
Olin, KL, Stearns, DM, Armstrong, WH & Keen, CL (1994) Comparative retention/adsorption of 51 chromium ( 51 Cr) from 51 Cr chloride, 51 Cr nicotinate, and 51 Cr picolinate in a rat model. Trace Elements and Electrolytes 11, 182–186.Google Scholar
Pittler, MH, Stevinson, C & Ernst, E (2003) Chromium picolinate for reducing body weight: Meta-analysis of randomized trials. International Journal of Obesity 27, 522–529.CrossRefGoogle ScholarPubMed
Ravina, A, Slezak, L, Mirsky, N & Anderson, RA (1999a) Control of steroid-induced diabetes with supplemental chromium. Journal of Trace Elements in Medicine and Biology 12, 375–378.3.0.CO;2-R>CrossRefGoogle Scholar
Ravina, A, Slezak, L, Mirsky, N, Bryden, NA & Anderson, RA, (1999b) Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabetic Medicine 16, 164–167.CrossRefGoogle ScholarPubMed
Shute, AA & Vincent, JB (2001) The stability of the biomimetic cation triaqua-μ-oxohexapropionatotrichromium(III) in vivo in rats. Polyhedron 20, 2241–2252.CrossRefGoogle Scholar
Shute, AA & Vincent, JB (2002) The fate of the biomimetic cation triaqua-μ-oxohexapropionatotrichromium(III) in rats. Journal of Inorganic Biochemistry 89, 272–278.CrossRefGoogle ScholarPubMed
Speetjens, JK, Collins, RA, Vincent, JB & Woski, SA (1999a) The nutritional supplement chromium(III) tris(picolinate) cleaves DNA. Chemical Research in Toxicology 12, 483–487.CrossRefGoogle ScholarPubMed
Speetjens, JK, Parand, A, Crowder, MW, Vincent, JB & Woski, SA (1999b) Low-molecular-weight chromium-binding substance and biomimetic [Cr 3 O(O 2 CCH 2 CH 3 ) 6 (H 2 O) 3 ] + do not cleave DNA under physiologically-relevant conditions. Polyhedron 18, 2617–2624.CrossRefGoogle Scholar
Stearns, DM (2000) Is chromium a trace essential element?. Biofactors 11, 149–162.CrossRefGoogle Scholar
Stearns, DM, Silveira, SM, Wolf, KK & Luke, AM (2002) Chromium(III) tris(picolinate) is mutagenic at the hypoxanthine (guanine) phosphoribosyltransferase locus in Chinese hamster ovary cells. Mutation Research 513, 135–142.CrossRefGoogle ScholarPubMed
Stearns, DM, Wise, JP Sr Patierno, SR & Wetterhahn, KE (1995) Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. FASEB Journal 9, 1643–1648.CrossRefGoogle ScholarPubMed
Striffler, JS, Law, JS, Polansky, MM, Bhathena, SJ & Anderson, RA (1995) Chromium improves insulin response to glucose in rats. Metabolism 44, 1314–1320.CrossRefGoogle ScholarPubMed
Striffler, JS, Polansky, MM & Anderson, RA (1999) Overproduction of insulin in the chromium-deficient rat. Metabolism 48, 1063–1068.CrossRefGoogle ScholarPubMed
Sugden, KD, Geer, RD & Rogers, SG (1992) Oxygen radical-mediated DNA damage by redox-active Cr(III) complexes. Biochemistry 31, 11626–11631.CrossRefGoogle ScholarPubMed
Sun, Y, Clodfelder, BJ, Shute, AA, Irvin, T & Vincent, JB (2002) The biomimetic [Cr 3 O(O 2 CCH 2 CH 3 ) 6 (H 2 O) 3 ] + decreases plasma insulin, cholesterol and triglycerides in healthy and type II diabetic rats but not type I diabetic rats. Journal of Biological Inorganic Chemistry 7, 852–862.CrossRefGoogle Scholar
Sun, Y, Mallya, K, Ramirez, J & Vincent, JB (1999) The biomimetic [Cr 3 O(O 2 CCH 2 CH 3 ) 6 (H 2 O) 3 ] + decreases cholesterol and triglycerides in rats: towards chromium-containing therapeutics. Journal of Biological Inorganic Chemistry 4, 838–845.CrossRefGoogle Scholar
Sun, Y, Ramirez, J, Woski, SA & Vincent, JB (2000) The binding of chromium to low-molecular-weight chromium-binding substance (LMWCr) and the transfer of chromium from transfer and chromium picolinate to LMWCr. Journal of Biological Inorganic Chemistry 5, 129–136.CrossRefGoogle ScholarPubMed
Trumbo, P, Yates, AA, Schlickek, S & Poos, M (2001) Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, molybdenum, nickel, silicon, vanadium, and zinc. Journal of the American Dietetic Association 101, 294–301.CrossRefGoogle ScholarPubMed
Vincent, JB (2000a) The biochemistry of chromium. Journal of Nutrition 130, 715–718.CrossRefGoogle ScholarPubMed
Vincent, JB (2000b) Elucidating a biological role for chromium at a molecular level. Accounts of Chemical Research 33, 503–510.CrossRefGoogle ScholarPubMed
Vincent, JB (2000c) Quest for the molecular mechanism of chromium action and its relationship to diabetes. Nutrition Reviews 58, 67–72.CrossRefGoogle ScholarPubMed
Vincent, JB (2001) The bioinorganic chemistry of chromium(III). Polyhedron 20, 1–26.CrossRefGoogle Scholar
Vincent, JB (2003) The potential value and potential toxicity of chromium picolinate as a nutritional supplement, weight loss agent, and muscle development agent. Sports Medicine 33, 213–230.CrossRefGoogle ScholarPubMed
Wada, O, Wu, GY, Yamamoto, A, Manabe, S & Ono, T (1983) Purification and chromium-excretory function of low-molecular-weight, chromium-binding substances from dog liver. Environmental Research 32, 228–239.CrossRefGoogle ScholarPubMed
Wasser, WG & D'Agati, VD (1997) Chromic renal failure after ingestion of over-the-counter chromium picolinate. Annals of Internal Medicine 126 410.CrossRefGoogle Scholar
Yamamoto, A, Ono, T & Wada, O (1987) Isolation of a biologically active low-molecular-mass chromium compound from rabbit liver. European Journal of Biochemistry 165, 627–631.CrossRefGoogle ScholarPubMed
Yamamoto, A, Wada, O & Ono, T (1984) Distribution and chromium-binding capacity of a low-molecular-weight, chromium-binding substance in mice. Journal of Inorganic Biochemistry 22, 91–102.CrossRefGoogle ScholarPubMed
Yamamoto, A, Wada, O & Suzuki, H (1988) Purification and properties of biologically active chromium complex from bovine colostrum. Journal of Nutrition 118, 39–45.CrossRefGoogle ScholarPubMed