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Nutrition and cancer prevention: diet-gene interactions

Published online by Cambridge University Press:  05 March 2007

John C. Mathers
John C. Mathers*
Affiliation:
Human Nutrition Research Centre, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
*
Corresponding author: Professor John Mathers, fax +44 191 222 8684, [email protected]
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Abstract

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Cancer is the major cause of death in the UK, and the Government has set a target to reduce death rate from cancer in individuals 75 years by ≥20% by 2010. Whilst earlier diagnosis and more effective treatments will contribute to meeting this target, there are considerable opportunities to prevent cancer by improving diet and other aspects of lifestyle. There is now a good understanding of the biological basis of carcinogenesis, which is providing the basis for mechanistic investigation of the chemo-preventive properties of certain foods and food components. It is becoming increasingly clear that there are important interactions between an individual's genotype (characterised by single nucleotide polymorphisms in particular genes) and habitual diet that modulate the risk of developing cancer. The technology to support this post-genomic revolution in nutrition research is now widely available, but brings with it considerable challenges in terms of study design and ethics. However, in the absence of a robust body of evidence on which dietary strategies will benefit which individuals, soundly based genetically-targeted nutrition advice to the public on cancer prevention is a little way in the future.

Keywords

Cancer preventionDiet-gene interactionsNutrition advice
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 3 , August 2003 , pp. 605 - 610
Copyright
Copyright © The Nutrition Society 2003

References

Ambrosone, CB, Freudenheim, JL, Thompson, PA, Bowman, E, Vena, JE, Marshall, JR, Graham, S, Laughlin, R, Nemeto, T & Sheilds, PG (1999) Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Research 59, 602–606.Google ScholarPubMed
Ames, BN & Wakimoto, P (2002) Are vitamin and mineral deficiencies a major cancer risk?. Nature Reviews Cancer 2, 694–704.CrossRefGoogle ScholarPubMed
Ballestar, E & Esteller, M (2002) The impact of chromatin in human cancer: linking DNA methylation to gene silencing. Carcinogenesis 23, 1103–1109.CrossRefGoogle ScholarPubMed
Baylin, SB, Herman, JG, Graff, JR, Vertino, PM & Issa, JP (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia. Advances in Cancer Research 72, 141–196.CrossRefGoogle ScholarPubMed
Burn, J, Chapman, PD, Bishop, DT, Smalley, S, Mickleburgh, I, West, S & Mathers, JC (2001) Susceptibility markers in colorectal cancer. In Biomarkers in Cancer Chemoprevention, pp.131–147. [Miller, AB, Bartsch, H, Boffetta, P, Dragsted, L and Vanio, H, editor]. Lyon, France: International Agency for Research on Cancer.Google Scholar
Cameron, EE, Bachman, KE, Myohanen, S, Herman, JG, Baylin, SB (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Genetics 21, 103–107.CrossRefGoogle ScholarPubMed
Department of Health (1998) Nutritional Aspects of the Development of Cancer. Report on Health and Social Subjects no. 48 London: The Stationery Office.Google Scholar
Department of Health (1999) Saving Lives. Our Healthier Nation. London: The Stationery Office.Google Scholar
Dobbie, Z, Heinimann, K, Bishop, DT, Muller, H & Scott, RJ (1997) Identification of a modifier gene locus on chromosome 1p35–36 in familial adenomatous polyposis. Human Genetics 99, 653–657.CrossRefGoogle ScholarPubMed
Doll, R & Peto, R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Journal of the National Cancer Institute 66, 1191–1308.CrossRefGoogle ScholarPubMed
Ferguson-Smith, AC & Surani, MA (2001) Imprinting and the epigenetic asymmetry between parental genomes. Science 293, 1086–1089.CrossRefGoogle ScholarPubMed
Frisco, S, Choi, S-W, Girelli, D, Mason, JB, Dolnikowski, GG, Bagley, PJ, Olivieri, O, Jacques, PF, Rosenberg, IH, Corrocher, R & Selhub, J (2002) A common mutation in the 5, 10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proceedings of the National Academy of Sciences USA 99, 5606–5611.CrossRefGoogle Scholar
Garcia-Closas, M, Rothman, N & Lubin, J (1999) Misclassification in case-control studies of gene-environment interactions: Assessment of bias and sample size. Cancer Epidemiology, Biomarkers and Prevention 8, 1043–1050.Google ScholarPubMed
Hahn, H (2001) Genetically determined susceptibility markers in skin cancer and their application to chemoprevention. in Biomarkers in Cancer Chemoprevention, pp. 93–100 [Miller, AB, Bartsch, H, Boffetta, P, Dragsted, L and Vanio, H, editors]. Lyon, France: International Agency for Research on Cancer.Google Scholar
Hanahan, D & Weinberg, RA (2000) The hallmarks of cancer. Cell 100, 57–70.CrossRefGoogle ScholarPubMed
Hardman, AE (2001) Physical activity and cancer risk. Proceedings of the Nutrition Society 60, 107–113.CrossRefGoogle ScholarPubMed
Issa, JP (2002) Epigenetic variation and human disease. Journal of Nutrition 132, Suppl., 2388S–2392S.CrossRefGoogle ScholarPubMed
Issa, JP, Ahuja, N, Toyota, M, Bronner, MP & Brentnall, TA (2001) Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Research 61, 3573–3577.Google ScholarPubMed
Jackson, SP (2002) Sensing and repairing DNA double-strand breaks. Carcinogenesis 23, 687–696.CrossRefGoogle ScholarPubMed
Jhaveri, MS, Wagner, C & Trepel, JB (2001) Impact of extracellular folate levels on global gene expression. Molecular Pharmacology 60, 1288–1295.CrossRefGoogle ScholarPubMed
Johnson, IT (2001) Mechanisms and anticarcinogenic effects of diet-related apoptosis in the intestinal mucosa. Nutrition Research Reviews 14, 229–256.CrossRefGoogle ScholarPubMed
Kampman, E, Slattery, ML, Bigler, J, Leppert, M, Samowitz, W, Caan, BJ & Potter, JD (1999) Meat consumption, genetic susceptibility, and colon cancer risk: A United States multicenter case-control study. Cancer Epidemiology, Biomarkers and Prevention 8, 15–24.Google Scholar
Kelloff, GJ, Boone, CW, Sigman, CC & Greenwald, P (1996) Chemoprevention of colorectal cancer. In Prevention and Early Detection of Colorectal Cancer, pp. 115–139 [Young, GP, Rozen, P, Levin, B, editors] London: WB Saunders company Ltd.Google Scholar
Lin, HJ, Probst-Hensch, NM, Louie, AD, Kau, IH, Witte, JS, Ingles, SA, Frankl, HD, Lee, ER & Haile, RW (1998) Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas. Cancer Epidemiology, Biomarkers and Prevention 7, 647–652.Google ScholarPubMed
Lippmann, SM, Lee, JJ & Sabichi, AL (1998) Cancer chemoprevention: progress and promise. Journal of the National Cancer Institute 90, 1514–1527.CrossRefGoogle Scholar
Mitrunen, K, Sillanpaa, P, Kataja, V, Eskelinen, M, Kosma, V-M, Benhamou, S, Uusitupa, M & Hirvonen, A (2001) Association between manganese superoxide dismutase ( MnSOD ) gene polymorphism and breast cancer risk. Carcinogenesis 22, 827–829.CrossRefGoogle ScholarPubMed
Nair, U & Bartsch, H (2001) Metabolic polymorphisms as susceptibility markers for lung and oral cavity cancer. in Biomarkers in Cancer Chemoprevention, pp. 271–290[Miller, AB, Bartsch, H, Boffetta, P, Dragsted, L, Vanio, H,editord]. Lyon, France International Agency for Research on Cancer.Google Scholar
Okoji, RS, Yu, RC, Maronpot, RR & Froines, JR (2002) Sodium arsenite administration via drinking water increases genomewide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. Carcinogenesis 23, 777–785.CrossRefGoogle ScholarPubMed
Omenn, GS, Goodman, GE, Thornquist, MD, Balmes, J, Cullen, MR, Glass, A, Keogh, JP, Meyskens, FL, Valanis, B, Williams, JH, Barnham, S & Hammar, S (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 334, 1150–1155.CrossRefGoogle ScholarPubMed
Reale, MA & Fearon, ER (1996) Gene defects in colorectal tumorigenesis. In Prevention and Early Detection of Colorectal Cancer, 62–86 [Young, GP, Rozen, P, Levin, B,editors]. London: WB Saunders Company Ltd.Google Scholar
Reik, W, Dean, W & Walter, J (2001) Epigenetic reprogramming in mammalian development. Science 293, 1089–1093.CrossRefGoogle ScholarPubMed
Rideout, WM III, Eggan, K & Jaenish, R (2001) Nuclear cloning and epigenetic reprogramming of the genome. Science 293, 1093–1098.CrossRefGoogle ScholarPubMed
Robertson, KD & Jones, PA (2000) DNA methylation: past, present and future directions. Carcinogenesis 21, 461–467.CrossRefGoogle ScholarPubMed
Rosenblum, JS, Gilula, NB & Lerner, RA (1996) On signal sequence polymorphisms and diseases of distribution. Proceedings of the National Academy of Sciences USA 93, 4471–4473.CrossRefGoogle ScholarPubMed
Sachidanandam, R, Weissman, D, Schmidt, SC, Kakol, JM, Stein, LD, Marth, G et al.. (2001) A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409, 928–933.Google ScholarPubMed
Sporn, MB & Suh, N (2002) Chemoprevention: an essential approach to controlling cancer. Nature Reviews Cancer 2, 537–543.CrossRefGoogle ScholarPubMed
Steinbach, G, Lynch, PM, Phillips, RK, Wallace, MH, Hawk, E, Gordon, GB, Wakabayashi, N, Saunders, B, Shen, Y, Fujimura, T, Su, LK & Levin, B (2000) The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. New England Journal of Medicine 342, 1946–1952.CrossRefGoogle ScholarPubMed
The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New England Journal of Medicine 330, 1029–1035.CrossRefGoogle Scholar
Welfare, MR, Cooper, J, Bassendine, MF & Daly, AK (1997) Relationship between acetylator status, smoking, and diet and colorectal cancer in the north-east of England. Carcinogenesis 18, 1351–1354.CrossRefGoogle ScholarPubMed
World Cancer Research Fund/American Institute of Cancer Research (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, DC World Cancer Research Fund/American Institute of Cancer Research.Google Scholar
Ye, Z & Parry, JM (2002) Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer risk. Medical Science Monitor 8, CR558–CR565.Google ScholarPubMed
Yu, Z, Chen, J, Ford, B, Brackley, M & Glickman, BW (1999) Human DNA repair systems: an overview. Environmental and Molecular Mutagenesis 33, 3–20.3.0.CO;2-L>CrossRefGoogle ScholarPubMed